Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
The ability to forecast the weather of the geospace environment depends critically on the ability to accurately model the dynamics of the coupled magnetosphere-ionosphere (MI) system. The MI interaction involves a set of electrodynamic and plasma...
The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space...
Proteins -- Structure -- Data processing. Proteins -- Analysis -- Data processing. Nuclear magnetic resonance spectroscopy. Oligomers -- Analysis -- Data processing.
Symmetric homo-oligomers (protein complexes with similar subunits arranged symmetrically) play pivotal roles in complex biological processes such as ion transport and cellular regulation. Structure determination of these complexes is necessary in...
Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
Order picking systems -- Automation -- Computer simulation.
This research ventures into areas beyond traditional control frameworks in its focus. It integrates holonic concepts into a hierarchical control framework of a complex automated order fulfillment technology. Simulation of an actual full-scale order...
Little is known about the emergence of life from nonliving precursors. A key missing- piece is the origin of homochirality: nearly all life is characterized by exclusively dextrorotary sugars and levorotary amino acids. The research presented in...
Production of fuel ethanol from cellulosic materials is a potentially attractive way to meet sustainability, energy security, and environmental goals. However, the high cost of processing using current technology has thus far prevented...
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Cupredoxins, such as stellacyanin, plastocyanin, amicyanin, rusticyanin, and azurin perform electron transfer (ET) reactions with partner protein(s) in the cell. The role of the redox cofactor in these proteins is played by a copper ion, which...
Sepsis is a worldwide problem with an annual mortality rate reaching as high as 45%. Understanding its pathogenesis and the innate immune response to infection is key to the development of new treatments. CD163, a monocyte/macrophage-specific...
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Bayesian nonparametric methods have become increasingly popular in machine learning for their ability to allow the data to determine model complexity. In particular, Bayesian nonparametric versions of common latent variable models can learn as...
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Telecommunication -- Traffic -- Measurement -- Statistical methods. IEEE 802.11 (Standard). Universities and colleges -- Computer networks -- New Hampshire -- Hanover -- Case studies.
The edge of the Internet is increasingly wireless. Enterprises large and small, homeowners, and even whole cities have deployed Wi-Fi networks for their users, and many users never need to--or never bother to--use the wired network. With the advent...
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Clinical medicine -- Decision making. ; Medical informatics. ; Patient participation. ; Osteoarthritis -- Treatment. ; Knee -- Diseases -- Treatment. ; Decision Making. ; Decision Support Techniques.
Problem Statement. Effective patients' decision aids (PtDAs) help patients understand clinical information and reduce decisional conflict. PtDAs that also explicitly provide guidance through four """"Deliberative Steps"""" may achieve additional...
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
The image of a child standing at the side of a creek and skipping stones across it exemplifies how we tend to mentally separate aquatic habitats from dry land. But there is a constant exchange of materials from land to streams, and vice-versa....
One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
As the human population increases, it is imperative that we develop strategies to improve agricultural productivity to meet the growing demand for food, fuel and fiber. More than 2 billion people suffer from "hidden hunger" (a lack of essential...
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...