Dartmouth Digital Library Program

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Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
Dartmouth Dissertations

Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

Conceptual processing of concrete objects in the brain / by Melissa M. Rundle.
How is concrete conceptual information represented in the brain? Little is known about the neural organization for details of concrete objects when presented as words. The goal of the first two studies was to investigate this. In the third study,...
Dartmouth Dissertations

A photoexcited three-component electron-hole plasma in type II GaAs/AlAs quantum wells.
Electron-hole droplets. Plasma (Ionized gases). Quantum wells.
Dartmouth Dissertations

Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
Dartmouth Dissertations

Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
Dartmouth Dissertations

Quantitative risk analysis of computer networks.
Computer networks -- Security measures. Computer security. Risk assessment. Operating systems (Computers) -- Evaluation.
Quantitative Risk Analysis of Computer Networks (QSRA) addresses the problem of risk opacity of software in networks. It allows risk managers to get a detailed and comprehensive snapshot of the constitutive software on the network, assess its risk...
Dartmouth Dissertations

Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Dartmouth Dissertations

The effects of context and familiarity on person perception: examining the neural substrates of facial attractiveness.
Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
Dartmouth Dissertations

The importance of dosage of core binding factors α and ß in hematopoietic development.
Hematopoiesis -- Regulation. ; Transcription factors.
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
Dartmouth Dissertations

Bilingual and monolingual brains compared: a fMRI study of semantic processing.
Bilingualism -- Physiological aspects. ; Neurolinguistics. Cognition -- Physiological aspects. ; Brain -- Localization of functions.
Does early and sustained experience with two languages in childhood modify how language is processed in the adult bilingual brain? Does extensive exposure to two languages influence language processing in the bilingual brain as compared to...
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
Dartmouth Dissertations

The experimental analysis of mutlitple computationally-driven methods for the deletion of broadly distributed T cell epitopes in a functional biotherapeutic candidate / by Regina Salvat
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
Dartmouth Dissertations

ACAT1 blockage stimulates autophagy to emeliorate Alzheimer's disease / by Yohei Shibuya
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the aging population. Currently, there is no cure for AD. The hallmark of AD consists of extracellular amyloid plaques, mainly composed...
Dartmouth Dissertations

Interrogation of autolysins as a source of novel bacteriolytic agents / by Daniel Carmen Osipovitch
Staphylococcus aureus is a formidable pathogen, and its high morbidity and mortality rates are compounded by its ability to quickly develop antibiotic resistance. The current antimicrobial pipeline is inadequate to curb this mounting public health...
Dartmouth Dissertations

A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
Placenta; Maternal-fetal exchange.
Dartmouth Dissertations

Mutations that compromise cohesion predispose chiasmate and achiasmate chromosomes to age-dependent nondisjunction in Drosophila oocytes.
Chromosome abnormalities. Ovum. Maternal age. Aneuploidy. Aging -- Genetic aspects. Drosophila -- Molecular genetics. Nondisjunction.
Aneuploidy is the leading cause of pregnancy loss and birth defects in humans. At least 5% of all recognized pregnancies are aneuploid. Maternal meiosis is especially error-prone and the rate of chromosome missegregation increases exponentially...
Dartmouth Dissertations

Improving MHC-peptide binding prediction from sparse data with a multi-allele graphical model and active learning / by Li Jiang
The recognition of foreign peptides by MHC (Major Histocompatibility Complex) proteins is a critical step in the immune response mounted by higher vertebrates against pathogens. MHC proteins have many allelic variants, each recognizing different...
Dartmouth Dissertations

Measuring quality of life in economic evaluations of treatment for severe mental illness.
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Dartmouth Dissertations

Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
Dendritic cells. Biological response modifiers. Immune response -- Regulation. T cells. CD antigens. Dendritic Cells -- Immunology. Receptors
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature...
Dartmouth Dissertations

The identification and characterization of aldosterone responsive genes.
Aldosterone. ; Genetic regulation. ; Mineralocorticoids -- Receptors.
Dartmouth Dissertations

Nonequilibrium dynamics of phase transitions.
Phase transformations (Statistical physics) -- Mathematical models. ; Differential equations Nonlinear -- Numerical solutions. ; Nonequilibrium thermodynamics -- Mathematical models. ; Mathematical physics.
Phase transitions occur in such diverse and important systems as ferromagnets, liquid crystals and the early Universe. The dynamics of phase transitions such as these have been studied for decades, but the analytical models still need a great deal...
Dartmouth Dissertations

Investigation of the molecular basis of directed particle movement in the squid giant axon.
Axonal transport. ; Molecular dynamics. ; Squids.
Dartmouth Dissertations

Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
Dartmouth Dissertations

The role of core binding factor in the pathogenesis of the Moloney murine leukemia virus.
Retroviruses -- Pathogenesis. ; Virus diseases -- Pathogenesis. ; Genetic transcription -- Regulation. ; Viral genetics. ; Mouse leukemia viruses.
Dartmouth Dissertations

Biochemical characterization of postsynaptic membrane proteins.
Membrane proteins. ; Membrane proteins -- Analysis. ; Synapses.
Dartmouth Dissertations

A study of neutral amino acid and drug transport.
Placenta. ; Maternal-fetal exchange.
Dartmouth Dissertations

Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
Dartmouth Dissertations

The role of the core-binding factor ß (CBFß) subunit in the CBF heterodimeric complex.
DNA-binding proteins. ; Transcription factors -- Structure. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Regulation of the expression of MCL1, a viability promoting member of the BCL2 gene family.
Genetic regulation. ; Oncogenes. ; Hematopoiesis -- Regulation. ; Myeloid leukemia -- Genetic aspects.
Dartmouth Dissertations

The mitotic protein p62 is localized to the nucleolus during interphase.
Nucleoproteins. ; Mitosis. ; Nucleolus. ; Molecular biology.
Mitotic apparatuses from sea urchin embryos contain a protein (p62), previously shown to be required for mitotic progression. This protein localizes to the mitotic apparatus during cell division in urchin embryos and mammalian tissue culture cells....
Dartmouth Dissertations

Immunological and molecular characterization of a 62 kDa mitotic apparatus-associated protein important for mitotic progression.
Mitosis. ; Nucleoproteins. ; Sea urchins -- Embryos. ; Molecular biology.
A 62 kDa (p62) mitotic apparatus-associated protein has been shown to be important for the proper progression of mitosis in sea urchin embryos. The thesis project described here focuses on an immunological and a molecular characterization of p62....
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

Functional analysis of the Runx1 C-terminal sequences.
Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
Dartmouth Dissertations

Characterizing the heterodimerization interface of core-binding factors (CBFs).
Transcription factors. DNA-protein interactions. Genetic transcription -- Regulation.
Core-binding factors (CBFs) are a small family of transcription factors that play important roles in several developmental processes and in human disease. CBFs consist of CBFα (Runx1, Runx2, or Runx3) and CBFβ. The CBFα subunit binds DNA in a...
Dartmouth Dissertations

Biochemistry of isolated sea urchin mitotic apparatuses: protein phosphorylation and the control of mitosis.
Mitosis. ; Phosphorylation. ; Sea urchins -- Embryos.
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

Immunomodulation and the prevention of pathogen-driven ileitis.
Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
Dartmouth Dissertations

Identification and role of protein-protein interactions in signaling by the ethylene receptors of Arabidopsis.
Protein-protein interactions. ; Ethylene -- Receptors. ; Cellular signal transduction. ; Arabidopsis -- Genetics.
There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis. In this study, I tested the hypothesis that ethylene receptors mediate ethylene signaling through protein-protein interactions. First, I demonstrated that ethylene...
Dartmouth Dissertations

Molecular, cellular, and physiological characterization of the insulin receptor substrate 4.
Protein-tyrosine kinase. ; Insulin -- Receptors.
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Dartmouth Dissertations

Behavioral and neural investigations of behaviorally relevant features of auditory stimuli.
Auditory pathways -- Physiology. ; Auditory perception -- Physiological aspects. ; Directional hearing -- Physiological aspects. ; Speech perception -- Physiological aspects. ; Prefrontal cortex -- Physiology. ; Parietal lobes -- Physiology. ;...
Studies of the structure and function of the human and non-human primate auditory system have led to the hypothesis that it is composed of dorsal and ventral processing streams that are respectively dedicated to spatial and non-spatial processing....
Dartmouth Dissertations

Glucocorticoids affect the action of gamma interferon on human monocytes.
Glucocorticoids. ; Interferon. ; Monocytes. ; Immunity.
Dartmouth Dissertations

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