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Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Biochemical and electrophysiological analysis of the interaction between sodium channel α and ß subunits.
Sodium channels -- Genetic aspects. ; Sodium channels -- Chemistry. ; Sodium channels -- Physiology. ; Ion channels -- Genetic aspects. ; Neurotoxic agents -- Physiological effect.
Dartmouth Dissertations

Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
Dartmouth Dissertations

Ionotropic glutamate receptor structure determination by electron microscopy.
Glutamic acid -- Receptors. Cell receptors -- Structure-activity relationships. Ligand binding (Biochemistry). Glutamates.
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) function as paracrine and autocrine receptors throughout the body. Most studies have focused on their role in fast excitatory neuronal signaling, and learning and memory. In...
Dartmouth Dissertations

Studies on hepatic uroporphyrinogen oxidation and its role in the uroporphyria caused by polyhalogenated aromatic hydrocarbins.
Porphyrins -- Oxidation. Aromatic compounds. Hydrocarbons.
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Novel levels of Ras1 regulation in the human fungal pathogen, Candida albicans / by Amy Elizabeth Piispanen.
Neurotrophic functions.;""Growth factors."";""Exercise -- Physiological aspects."";""Cognition -- Effect of exercise on."";""Cognition -- physiology.""
Dartmouth Dissertations

The effects of Niemann-Pick Type C disease in the central nervous system: in vitro and in vivo analyses of neuronal function.
Neurons -- Physiology. ; Neurons -- Growth. ; Neurotrophic functions. ; Cholesterol -- Physiological effect. ; Purkinje cells. ; Gene fusion. ; Adenoviruses. ; Niemann-Pick Diseases. ; Central Nervous System -- growth & development.
Niemann-Pick Type C (NPC) disease is an autosomal, recessive, neurovisceral disorder associated with defects in cholesterol and glycolipid trafficking and metabolism, leading to the accumulation of cholesterol in the late endosomes and lysosomes....
Dartmouth Dissertations

5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Dartmouth Dissertations

The expression and activity of TP63 in the mammary epithelial regenerative hierarchy.
Tumor proteins. ; p53 antioncogene. ; Epithelial cells. ; Mammary glands -- Cytology. ; Stem cells. ; Regeneration (Biology). ; Genetic transcription -- Regulation. ; Cellular signal transduction.
Dartmouth Dissertations

Insights into the assembly and organization of higher-order septin structures.
Septins. ; Proteins -- Structure. ; Fluorescence spectroscopy. ; Molecular biology -- Instruments. ; GTP-Binding Proteins.
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Tools for studying Drosophila snRNAs: gene cloning and liposome fusion.
Drosophila. ; RNA.
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Investigation of the influence of lipids in ER to Golgi transport.
Membrane proteins -- Physiological transport. Coated vesicles -- Physiology. Phospholipids -- Physiological effect. Inositol phosphates -- Physiological effect. Carrier proteins -- Molecular aspects. Golgi apparatus. Endoplasmic...
The secretory pathway in eukaryotic cells is responsible for the exocytic and endocytic pathways, as well as for the delivery of proteins and lipids from their sites of synthesis to the cell surface and the different compartments of the...
Dartmouth Dissertations

Rabbit genomic clones for synovial fibroblast collagenase: tools for understanding connective tissue disease.
Collagenases. ; Fibroblasts. ; Connective tissues -- Diseases -- Genetic aspects. ; Clone cells. ; Rabbits.
Dartmouth Dissertations

The Vibrio cholerae AraC-like protein ToxT: activation of tcpA expression and domain organization.
Vibrio cholerae -- Molecular genetics. Genetic transcription -- Regulation. Promoters (Genetics). DNA-binding proteins.
ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Dissertations

Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
Dartmouth Dissertations

Distinct functions for diguanylate cyclases in regulating Pseudomonas aeruginosa PA14 surface-associated behaviors.
Pseudomonas aeruginosa -- Genetics. Biofilms -- Growth. Bacteria -- Motility. Guanylate cyclase. Cellular signal transduction.
Biofilm formation is a complex process culminating in a multicellular microbial structure encased in an extracellular matrix. In order for planktonic cells to initiate and proceed through biofilm formation, they must appropriately regulate a number...
Dartmouth Dissertations

Causes and consequences of DeltaNp63 expression in mammary epithelial progenitors.
Epithelium -- Tumors -- Genetic aspects. p53 antioncogene -- Regulation. Stem cells. Breast -- Cancer -- Genetic aspects. Breast -- Cancer -- Etiology. Medical Terms: TP63 protein, human; Tumor Suppressor Proteins -- genetics; Breast Neoplasms --...
Efforts to elucidate the events that account for breast cancer initiation have focused sharply on a small subset of mammary epithelial cells, referred to in this document at mammary stem cells, whose features may enable them to accumulate and...
Dartmouth Dissertations

Molecular function of the MADS floral organ identity proteins of APETALA3 and PISTILLATA in Arabidopsis.
Arabidopsis -- Genetics. Arabidopsis -- Molecular aspects. Transcription factors. DNA-binding proteins. Flowers -- Morphogenesis -- Molecular aspects.
APETALA3 ( AP3 ) and PISTILLATA ( PI ) are floral organ identity genes that are necessary and sufficient for petal and stamen development. Surprisingly little is known about molecular mechanisms by which AP3 and PI proteins direct floral organ...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Heat shock and regulatory elements in Drosophila small hsp genes.
Heat shock proteins. Genetic transformation. Drosophila.
Dartmouth Dissertations

Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Dartmouth Dissertations

A role for TP63 in breast cancer initiation.
Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying...
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

ACAT1 knockdown gene therapy in a mouse model of Alzheimer's disease / by Stephanie Rachel Murphy.
Alzheimer's Disease (AD) is a devastating neurodegenerative disease its pathogenesis is linked with cholesterol metabolism. Acyl-CoA:cholesterol acyltransferases (ACATs) are key enzymes involved in cholesterol homeostasis that catalyze the...
Dartmouth Dissertations

ACAT1 blockage stimulates autophagy to emeliorate Alzheimer's disease / by Yohei Shibuya
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the aging population. Currently, there is no cure for AD. The hallmark of AD consists of extracellular amyloid plaques, mainly composed...
Dartmouth Dissertations

Identification and characterization of two mutants that affect Drosophila phototransduction.
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Dartmouth Dissertations

Cell cycle characteristics of a microtubule-associated protein that is a component of the mitotic apparatus.
Phosphoproteins. ; Microtubules. ; Mitosis. ; Tubulins.
Dartmouth Dissertations

Cortical contractility in amphibian eggs and embryos: response to the calcium ionophore A23187.
Amphibians -- Physiology. ; Embryology Experimental.
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

Use of ionomics to identify genes that play a role in Arabidopsis metal homeostasis.
Arabidopsis -- Genetics. ; Cobalt -- Metabolism -- Genetic aspects. ; Iron -- Metabolism -- Genetic aspects. ; Nickel -- Metabolism -- Genetic aspects. ; Homeostasis.
Understanding trace element homeostasis in plants has a direct impact on global health. Much of the developing world suffers from nutrient deficiencies, and subsists on a plant based diet often lacking bioavailable nutrients like iron and zinc. At...
Dartmouth Dissertations

The importance of dosage of core binding factors α and ß in hematopoietic development.
Hematopoiesis -- Regulation. ; Transcription factors.
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
Dartmouth Dissertations

Biochemical characterization of prion conversion.
Prion diseases. Prions. Proteolytic enzymes -- Pathophysiology. Proteins -- Conformation.
Prion diseases are infectious neurodegenerative disorders characterized by a conformational change of the host-encoded prion protein. The normal nonpathogenic isoform of the prion protein (PrPc) is primarily composed of α-helices and very low...
Dartmouth Dissertations

The role of lysosomal cysteine proteases in endocytosis-mediated retinal degeneration
Many retinal degenerative diseases result in blindness. The causes and clinical progression of these diseases are heterogeneous in nature. In many instances the genes involved are known, yet the molecular mechanisms leading to blindness still...
Dartmouth Dissertations

Splice variation-specific cellular and biochemical function of the formin INF2
Formins are actin nucleators that modulate the nucleation and elongation of actin filaments. Formin homology 1 (FH1) and formin homology 2 (FH2) domains play a key role in formin-mediated actin dynamics. INF2 is a unique formin which can both...
Dartmouth Dissertations

Novel roles for phosphorylation and coiled-coil domains in septin organization.
The septins are a class of GTP-binding cytoskeletal proteins conserved throughout eukaryotes. They were first described as a set of cell division cycle mutants in the budding yeast Saccharomyces cerevisiae, but since their initial discovery septins...
Dartmouth Dissertations

Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations

Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae.
Iron-sulfur proteins.
Dartmouth Dissertations

Isolation and characterization of the nuclear gene and gene product of COX12, the gene encoding subunit VIb of cytochrome c oxidase of Saccharomyces cerevisiae.
Cytochrome oxidase -- Genetic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Molecular microbiology.
Dartmouth Dissertations

$Isolation and characterization of a cortical secretory vesicle membrane fraction.$
Isolation and characterization of a cortical secretory vesicle membrane fraction.
Cell membranes. ; Membrane fusion. ; Membrane proteins.
Dartmouth Dissertations

Biochemistry of isolated sea urchin mitotic apparatuses: protein phosphorylation and the control of mitosis.
Mitosis. ; Phosphorylation. ; Sea urchins -- Embryos.
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Thermodynamics of copper binding to proteins from biological systems: development and application of ITC.
Copper proteins. Copper enzymes. Protein binding. Thermodynamics. Binding sites (Biochemistry) -- Thermodynamics. Thermometric titration. Calorimetry.
Bioinorganic chemistry is the study of metal in biological systems. While transition metals such as copper, iron and zinc are essential to all living organisms, they can also be extremely toxic. The same properties that make them necessary render...
Dartmouth Dissertations

The dual role of the Pseudomonas aeruginosa type I-F CRISPR-Cas system in group behavior modification and viral immunity / by Gary E. Heussler
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
Dartmouth Dissertations

Investigating the role of ARP2/3 complex and formins in assembly of cell surface protusions.
Cells -- Motility. Cell membranes -- Formation. Cytoskeletal proteins. Actin. Cell Movement -- physiology. Actin-Related Protein 2-3 Complex -- physiology. Microvilli.
Despite years of study, the mechanisms by which cells protrude their leading edge during cell motility are still highly controversial. Two candidates for mediating this actin-based process are the Arp2/3 complex and formin family proteins. In order...
Dartmouth Dissertations

Genome-wide analysis of human cell cycle gene expression and its regulation by forkhead box genes.
Cell cycle -- Regulation.; Transcription factors. ; Luciferases. ; Forkhead Transcription Factors -- genetics.
Successful completion of the cell division cycle is critical for cellular duplication and survival. There are many regulators and checkpoints to ensure the proper cell cycle progression. Disruption of the machinery involved in completion, error...
Dartmouth Dissertations

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