Dartmouth Digital Library Program

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Helix aspersa NHE1: cDNA cloning and characterization.
Sodium cotransport systems. Chemoreceptors. Respiration -- Regulation -- Genetic aspects. Brown garden snail -- Respiration. Carbon dioxide in the body. Arginine. Antisense DNA -- Genetics.
Studies of central CO 2 chemosensors are hampered by the complexity of mammalian central nervous systems. Our laboratory developed the pulmonate snail, Helix aspersa , as a relatively simple alternative to mammalian models. A question concerning...
Dartmouth Dissertations

Analysis of aberrant cell cycle regulation in pancreatic ductal adenocarcinoma uncovers novel thereapeutic approaches
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
Dartmouth Dissertations

$Influence of the infracerebellar nucleus on respiratory activity.$
Influence of the infracerebellar nucleus on respiratory activity.
Respiration -- Regulation. ; Cerebellar nuclei.
Dartmouth Dissertations

The novel p53 target gene STK17A : implications for cancer therapy / by Pingping Mao
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

Serotonin signaling in the nucleus tractus solitarius modulates the larybgeal chemoreflex : implications for sudden infant death syndrome / by William T. Donnelly
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Dartmouth Dissertations

Ionic basis of neuronal CO²/H+ chemosensitivity in the pulmonate snail, Helix aspersa.
Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
Dartmouth Dissertations

The functional roles of the rostral pons in the control of respiration in mammals.
Respiration -- Regulation. ; Cats -- Respiration. ; Rats -- Respiration. ; Pons Varolii -- Physiology.
Dartmouth Dissertations

Bethanechol and central respiratory control.
Bethanechol. ; Anesthetics.
Dartmouth Dissertations

The retinoid inducible nuclear receptor coregulator, RIP140: a limiting factor in retinoid and estrogen signaling.
Antineoplastic agents. Tretinoin. Nuclear receptors (Biochemistry). Genetic regulation.
Dartmouth Dissertations

CO2 chemoreceptor function in the pulmonate snail.
Helix (Mollusks) -- Respiration. ; Chemoreceptors. ; Carbonic anhydrase.
Dartmouth Dissertations

Actions of substances placed in the cat cerebrospinal fluid space.
Pharmacology, Experimental. ; Cats.
Dartmouth Dissertations

Respiratory regulation and central depressant drugs.
Drugs -- Physiological effect. ; Respiratory organs.
Dartmouth Dissertations

Respiratory-related hypoglossal activities in decerebrate cats.
Hypoglossal nerve. ; Airway (Medicine). ; Respiration.
Dartmouth Dissertations

A role for TP63 in breast cancer initiation.
Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Targeting G1 cyclins in cancer chemoprevention.
Bronchi -- Cancer -- Chemoprevention. ; Cyclins. ; Retinoids -- Therapeutic use. ; Cellular control mechanisms. ; G1 Phase.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer treatment and chemoprevention. There is a need for an in-depth understanding of the mechanisms that account for retinoid response or resistance in lung cancer...
Dartmouth Dissertations

The role of medullary raphé serotonergic neurons in central chemoreception during sleep and wakefulness in newborn piglets: relevance to the sudden infant death syndrome.
Serotoninergic mechanisms. ; Brain stem -- Physiology. ; Neurons -- Physiology. ; Respiration -- Regulation. ; Carbon dioxide -- Physiological effect. ; Chemoreceptors -- Physiology. ; Sudden infant death syndrome -- Pathogenesis
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

Modulation of the hypercapnic and hypoxic ventilatory responses by the medullary raphe region in conscious rats.
Respiration -- Regulation. ; Medulla oblongata -- Physiology. ; Hypercapnia. ; Anoxemia. ; Rats -- Respiration.
Serotonergic and non-serotonergic neurons located in the medullary raphe region of the mammalian brainstem are involved in numerous physiological processes. Concerning respiration, neurons in this region have been found to be chemosensitive, i.e.,...
Dartmouth Dissertations

Nuclear receptor corepression, negative feedback and transcription-based oscillation: Evidence for a novel form of nuclear receptor regulation.
Nuclear receptors (Biochemistry) Retinoids -- Receptors. Genetic regulation. Medical Term Receptors, Cytoplasmic and Nuclear -- genetics Receptors, Retinoic Acid -- genetics.
Nuclear receptors (NRs) are ligand-regulated transcription factors that control gene expression through interaction with coregulator proteins. Receptor interacting protein 140 (RIP140) is a ligand-inducible, ligand-dependent NR corepressor with...
Dartmouth Dissertations

Altered serotonin signaling impairs cardiorespiratory control in early postnatal development : relevance for the SIDS / by Karlene T. Barrett.
Serotonin -- Receptors.;""Serotoninergic mechanisms -- Sudden infant death syndrome -- Pathogenesis -- Respiration -- Regulation -- Medulla oblongata -- Physiology.""
Dartmouth Dissertations

The use of computer models to capture, understand and control dynamic brain processes.
Brain -- Physiology -- Mathematical models. Brain stem -- Effect of chemicals on. Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Dartmouth Dissertations

Control of the Notch signaling pathway in mammary gland development and carcinogenesis by the stem cell specific transcription factor [delta]Np63
The TP63 gene produces a series of transcription factors as a result of multiple promoter usage and alternative splicing. These protein products are members of the p53 family of transcription factors due to strong structural similarity with...
Dartmouth Dissertations

Investigation of the ISG15 deisgylase UBP43 in carcinogenesis : tumor suppressor or oncogene? / by Fadzai Chinyengetere.
ISGylation is a type 1 interferon-regulated process that involves conjugation of ISG15, an ubiquitin-like protein, to target proteins. This posttranslational modification is reversed by a deubiquitinase known as UBP43 or USP18. UBP43 is deregulated...
Dartmouth Dissertations

Role of melanin concentrating hormone (MCH) containing neurons in the lateral hypothalamus in cardiorespiratory control and energy balance / by Ningjing Li.
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral...
Dartmouth Dissertations

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