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ORD and cohesin at the intersection of recombination and cohesion during Drosophila meiosis.
Genetic recombination. ; Chromosome replication. ; Meiosis. ; Cell cycle -- Regulation. ; Drosophila -- Molecular genetics. ; Cell Cycle Proteins. ; Chromosome Segregation.
Proper regulation of chromosome segregation during cell division is essential to prevent aneuploidy. During mitosis as well as meiosis, the cohesin complex physically holds sister chromatids together and is necessary for proper segregation of...
Dartmouth Dissertations

The effects of Niemann-Pick Type C disease in the central nervous system: in vitro and in vivo analyses of neuronal function.
Neurons -- Physiology. ; Neurons -- Growth. ; Neurotrophic functions. ; Cholesterol -- Physiological effect. ; Purkinje cells. ; Gene fusion. ; Adenoviruses. ; Niemann-Pick Diseases. ; Central Nervous System -- growth & development.
Niemann-Pick Type C (NPC) disease is an autosomal, recessive, neurovisceral disorder associated with defects in cholesterol and glycolipid trafficking and metabolism, leading to the accumulation of cholesterol in the late endosomes and lysosomes....
Dartmouth Dissertations

Analyses of SOS-type DNA repair processes in mammalian cells
DNA repair. ; Mammals -- Cytology. ; Mutagenesis
Dartmouth Dissertations

Isolation and characterization of QCR9 the nuclear gene encoding the 7.3 kDa subunit 9 of the Saccharomyces cerevisiae bc1 complex.
Oxidoreductases. Cytochrome c. Saccharomyces cerevisiae.
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

The Pseudomonas fluorescens pho regulon and its role in modulating biofilm formation in response to environmental cues.
Pseudomonas fluorescens -- Genetics. Attachment mechanisms (Biology) Biofilms -- Growth. Phosphates -- Physiological effect. Medical Term: Biofilms -- growth and development. Adhesins, Bacterial.
Microbial biofilm formation is thought of as a developmental pathway, whereby cells progress through environmentally regulated and temporally distinct stages during transition from free-swimming lifestyles to members of a structured...
Dartmouth Dissertations

The Polycomb Group Complex PRC1 collaborates with cohesin to stabilize the synaptonemal complex and promote crossovers during meiosis / by Pei Zhou.
Lightning -- New Mexico -- Observations.;""Photon emission."";""X-rays -- Spectra -- Measurement -- Instruments."";""X-rays -- Spectra -- Mathematical models.""
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Efficient design and implementation of permutation algorithms on the memory hierarchy.
Computer algorithms. Permutations. Memory hierarchy (Computer science). Computer programming.
For many scientific applications, the data set cannot entirely fit in main memory. The data must reside out-of-core, i.e., on parallel disks. For many basic data-movement operations such as permuting, if the programmer does not design efficient...
Dartmouth Dissertations

Characterization of two S. Cerevisiae genes implicated in mRNA export: RAT7, encoding a novel nuclear pore complex protein and NPL3, encoding a putative hnRNP protein.
Messenger RNA -- Genetic aspects. Proteins -- Synthesis -- Genetic aspects. Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Mechanisms of survival and persistence of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Proteins -- Secretion. Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of the severe diarrheal disease cholera. Colonization of the host environment by V. cholerae requires the type IV toxin co-regulated pilus (TCP). Adequate colonization by V. cholerae is essential for cholera...
Dartmouth Dissertations

The role of the genes tra-4 and glp-5 in C. elegans development.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Generative organs. ; Caenorhabditis elegans -- Development. ; Genetic transcription -- Regulation.
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
Dartmouth Dissertations

Understanding the role of Toxoplasma gondii secreted rhoptry (ROP) and dense granule (GRA) effector proteins in host-parasite biology using reverse genetics / by Leah M. Rommereim
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
Dartmouth Dissertations

Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
Interleukin-2. ; Mutagenesis.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
Dartmouth Dissertations

Vibrio cholerae H-NS: investigation of regulated genes and structure-function analysis.
Vibrio cholerae -- Genetics. ; DNA-binding proteins. ; Genetic transcription -- Regulation. ; Bacterial proteins.
H-NS, an abundant nucleoid associated protein, has a role in silencing the expression of a variety of environmentally regulated genes during growth under nonpermissive conditions. A genetic approach was used to study H-NS regulation of genes in...
Dartmouth Dissertations

Mutational studies of simian virus 40 large T antigen.
Tumor antigens. ; SV40 (Virus).
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Characterization of Saccharomyces cerevisiae genes RAT8, RAT9/NUP85 and RAT10/NUP145.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Self-reconfiguring robots: designs, algorithms, and applications.
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Dartmouth Dissertations

Budding yeast discovery tools for neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to a variety of benign and malignant nervous system tumors. NF1 is caused by a mutation in the NF1 tumor suppressor gene, which encodes neurofibromin, a...
Dartmouth Dissertations

Characterization of type IVb pilus components essential for functional TCP of Vibrio cholerae O395, including implications on the hierarchy of microcolony formation and virulence / by Jarrad Matthew Marles.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Virulence (Microbiology) -- Molecular aspects. ; Fimbriae Proteins.
Vibrio cholerae is the etiological agent of the acute intestinal disorder cholera. The source of cholera infection is typically fecal contamination of potable water sources. V. cholerae is able to colonize the host intestine and trigger the onset...
Dartmouth Dissertations

A novel high-cell-density recombinant protein production system based on Ralstonia eutropha.
Recombinant proteins -- Synthesis. Ralstonia. Alcaligenes eutrophus. Organophosphorus compounds -- Synthesis. Proteomics. Microbial biotechnology. Industrial microbiology. Recombinant Proteins -- Biosynthesis.
Recombinant protein production has traditionally relied on organisms with well developed molecular biological tools, such as E. coli. However, E. coli is not suited for large industrial scale production due to its propensity to produce organic...
Dartmouth Dissertations

Structural characterization of the LysR-type virulence factor, AphB, and insight into its mehcanism of transcriptional activation at the tcpPH promoter in Vibrio cholerae
The LysR-type virulence regulator, AphB, initiates the Vibrio cholerae virulence cascade resulting in expression of the two critical virulence factors, toxin-coregulated pilus and cholera toxin, by activating transcription at the tcpPH promoter....
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
Dartmouth Dissertations

Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
Dartmouth Dissertations

Regulation of B lymphocyte proliferation and differentiation through CD40.
B cells. CD antigens. Immune response -- Regulation.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Identification of steroid-binding and phosphorylated sites within the glucocorticoid receptor
Glucocorticoids -- Receptors; Phosphorylation; Steroid-binding proteins
Dartmouth Dissertations

Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
Dartmouth Dissertations

Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
Dartmouth Dissertations

The present state of ordinal notation theory
Recursive functions. Mathematical notation.
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

The role of TonB-dependent receptors and alternate sigma factors in the Bradyrhizobium japonicum/soybean symbiosis.
Rhizobium -- Genetics. Cell receptors. Transcription factors. Bacteria.
Bradyrhizobium japonicum forms a nitrogen-fixing symbiosis with soybean. Signaling events, such as production of flavonoids and Nod factor, initiate the interaction, leading to formation of specialized root organs called nodules. A B. japonicum...
Dartmouth Dissertations

The in vitro generation and long-term culture of tumor-specific cytotoxic T-lymphocytes
Mouse leukemia viruses. ; Lymphocytes. ; T cells.
Dartmouth Dissertations

Molecular function of the MADS floral organ identity proteins of APETALA3 and PISTILLATA in Arabidopsis.
Arabidopsis -- Genetics. Arabidopsis -- Molecular aspects. Transcription factors. DNA-binding proteins. Flowers -- Morphogenesis -- Molecular aspects.
APETALA3 ( AP3 ) and PISTILLATA ( PI ) are floral organ identity genes that are necessary and sufficient for petal and stamen development. Surprisingly little is known about molecular mechanisms by which AP3 and PI proteins direct floral organ...
Dartmouth Dissertations

Circadian and non-circadian oscillators in Neurospora crassa.
Circadian rhythms. Neurospora crassa -- Genetics. Genetic transcription -- Regulation. Choline. Temperature. Circadian Rhythm -- genetics. Choline Deficiency -- genetics.
The circadian clock of the filamentous fungus, Neurospora crassa, consists of a frequency-white-collar ( frq-wc ) based and transcription-translation-derived oscillator. Negative feedback regulation is essential for the oscillatory process, in...
Dartmouth Dissertations

Decompositions of saturated ideals.
Ideals (Algebra) ; Functional analysis.
Dartmouth Dissertations

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