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- Random drift.
- Genetics -- Mathematical models. ; Stochastic processes.
- Dartmouth Dissertations
- Regulation of the expression of MCL1, a viability promoting member of the BCL2 gene family.
- Genetic regulation. ; Oncogenes. ; Hematopoiesis -- Regulation. ; Myeloid leukemia -- Genetic aspects.
- Dartmouth Dissertations
- Immunological and molecular characterization of a 62 kDa mitotic apparatus-associated protein important for mitotic progression.
- Mitosis. ; Nucleoproteins. ; Sea urchins -- Embryos. ; Molecular biology.
- A 62 kDa (p62) mitotic apparatus-associated protein has been shown to be important for the proper progression of mitosis in sea urchin embryos. The thesis project described here focuses on an immunological and a molecular characterization of p62....
- Dartmouth Dissertations
- N,N,N',N'-tetramethyl-P-phenylenediamine (TMPD) photoionization in nonpolar solvents.'
- Photoionization.
- Dartmouth Dissertations
- Photorearrangements of aryl halides.
- Photochemistry. Halides.
- Dartmouth Dissertations
- Multiphoton induced chemistry.
- Multiphoton processes.
- Dartmouth Dissertations
- Synthetic approaches to pyridocarbazoles via new indole and pyridine lithiaton methodology.
- Antineoplastic agents. ; Pyridocarbazoles.
- Dartmouth Dissertations
- Bcl-2 family proteins and the regulation of apoptosis.
- Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
- Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
- Dartmouth Dissertations
- The role of hepatic Mitochondrial thiosulfate: cyanide sulfurtransferase and serum albumin in cyanide detoxication.
- Cyanides -- Toxicology. ; Thiocyanates. ; Serum albumin.
- Dartmouth Dissertations
- High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
- Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
- Dartmouth Dissertations
- Organometallic chemistry with perfluorinated ligands. Investigation of group 8-10 metal complexes derived from octafluorocyclooctatetraene (OFCOT).
- Organometallic chemistry. ; Ligands.
- Dartmouth Dissertations
- Novel diphosphate surrogates: synthesis of potential inhibitors of cholesterol biosynthesis.
- Cholesterol -- Synthesis -- Inhibitors. ; Anticholesteremic agents -- Synthesis. ; Pyrophosphates.
- Dartmouth Dissertations
- Targeted manipulation of ß-globin promoter chromatin structure: implications for gene therapy of ß-hemoglobinopathies.
- Chromatin. ; Promoters (Genetics). ; Gene targeting. ; Globin genes -- Expression. ; Genetic vectors -- Therapeutic use. ; Hemoglobinopathy -- Treatment. ; Hemoglobinopathy -- Genetic aspects.
- Dartmouth Dissertations
- The development of magnetic susceptibility weighted magnetoencephalography
- Magnetoencephalography -- Technique.; Magnetic susceptibility.
- The measurement of human brain function is the goal of many noninvasive medical imaging modalities. Two sources of physiological contrast are commonly targeted to achieve this goal. The most direct approach to measuring neuronal activity is with...
- Dartmouth Dissertations
- Microstructure and mechanical properties of Fe55Mn19Al26 and Fe30Ni20Mn35Al15 / by Yifeng Liao.
- Iron alloys -- Mechanical properties.;""Iron alloys -- Microstructure -- Iron alloys -- Thermomechanical properties -- Intermetallic compounds -- Mechanical properties -- Intermetallic compounds -- Microstructure -- Intermetallic compounds --...
- Two alloys, Fe 55 Mn 19 Al 26 and Fe 30 Ni 20 Mn 35 Al 15 , were studied in this research project. The yield stress anomaly (YSA) of Fe 55 Mn 19 Al 26 single crystal was observed with a yield stress peak at 700 K. In situ TEM straining revealed...
- Dartmouth Dissertations
- Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
- Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
- Dartmouth Dissertations
- Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
- Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
- Dartmouth Dissertations
- Synthetic studies on sarpagine alkaloids.
- Alkaloids. Organic compounds -- Synthesis.
- Dartmouth Dissertations
- Synthesis of furans
- Furans.
- Dartmouth Dissertations
- The role of silver ion in the dimerization of benzocyclobutadiene; Various approaches to tetrakis (triflouromethyl) cyclobutadiene
- Cyclobutadiene; Silver ions;
- Dartmouth Dissertations
- Biochemistry of dioxygenated triterpenoids and steroids.
- Cholesterol. Squalene. Steroids.
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- Magnetic susceptibility imaging of magnetic nanoparticles / by Bradley W. Ficko.
- Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
- Dartmouth Dissertations
- Towards the experimental verification of macroscopic phenomena in quantum electrodynamics.
- Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
- The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
- Dartmouth Dissertations
- Quantifying optical tomography methods for biomolecular sensing / by Jennifer-Lynn H. Demers.
- Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
- Dartmouth Dissertations
- Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
- The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
- Dartmouth Dissertations
- The role of mediator in white-opaque switching / by Anda Zhang.
- The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
- Dartmouth Dissertations
- Sulfobetaines as novel inhibitors of squalene synthase. A model system for Δ4-3-ketosteroid isomerase.
- Cholesterol -- Synthesis. Enzymes -- Inhibition. Isomerases -- Synthesis.
- This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
- Dartmouth Dissertations
- Development of an apparatus for simultaneous trapping of ⁶Li-⁸⁷Rb Fermi-Bose mixtures.
- Trapped ions -- Instruments. Magnetooptical devices -- Design and construction. Atoms -- Cooling. Lithium ions. Rubidium -- Isotopes.
- Dartmouth Dissertations
- Part I: synthetic approaches to the perfluorotropylium ion; Part II: a new, mild and selective dehydrohalogenating reagent.
- Fluorine.
- Dartmouth Dissertations
- Optical constants of ZnS and ZnS:Mn thin films from 1.5 eV to 3.2 eV as determined by transverse photothermal deflection spectroscopy.
- Thin films -- Optical properties. Zinc sulfide -- Spectra.
- Dartmouth Dissertations
- Fractal models in the visual perception of textures and surfaces in nature.
- Visual perception. Fractals. Computer graphics. Uniformity of nature -- Mathematical models.
- Dartmouth Dissertations
- Automatic test pattern generation techniques for built-in self-test of digital circuits.
- Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
- Dartmouth Dissertations
- A new synthetic route to B-ring derivatives of TMD
- Bicyclic compounds -- Synthesis
- Dartmouth Dissertations
- A mechanistic investigation of the ring expansion of vinylcyclopropenes to metallacyclohexadienes and cyclopentadienyl complexes through the use of isotopically labelled ligands.
- Organometallic chemistry. Isomerization. Organoiridium compounds. Organoiron compounds. Organorhodium compounds.
- Dartmouth Dissertations
- Iron and iron chromium alloy--silica reaction studies.
- Alloys. Chemical reactions.
- Dartmouth Dissertations
- Heat shock and regulatory elements in Drosophila small hsp genes.
- Heat shock proteins. Genetic transformation. Drosophila.
- Dartmouth Dissertations
- UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
- Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
- Dartmouth Dissertations
- A far-infrared Smith-Purcell micro-radiator.
- Infrared radiation. Infrared sources. Infrared technology.
- Dartmouth Dissertations
- Characterization of proteins that bind the conserved LVb and core sequences of mammalian type C retroviral enhancers.
- Proteins. Protein binding. Mouse leukemia viruses. Retroviruses.
- Dartmouth Dissertations
- The transcriptional and post-transcriptional regulation of ecdysterone responsive genes.
- Genetic regulation. Ecdysterone. Drosophila -- Genetics.
- Dartmouth Dissertations
- Investigation of dynamic sea ice processes in the Weddell Sea during 1992.
- Sea ice -- Antarctica -- Weddell Sea.
- Through a series of case studies, signal processing and statistical tools, analyses of dynamic sea ice processes of drift, deformation, and ice pack expansion and decay are investigated for the Weddell Sea region during 1992. Cavitating fluid (CAV)...
- Dartmouth Dissertations
- Apoptosis as a mechanism of cell death by anticancer agents.
- Apoptosis. Antineoplastic agents.
- Dartmouth Dissertations
- Optical properties of some amorphous and crystalline Al Cu alloys.
- Aluminum-copper alloys -- Optical properties. Optical films. Alloys -- Analysis.
- Dartmouth Dissertations
- Spectroscopic and magnetic studies of the nickel metalloenzyme urease.
- Urease. Urease -- Magnetic properties. Urea. Hydrolysis.
- Dartmouth Dissertations
- Synthetic studies of ellipticine alkaloids and structurally related compounds.
- Alkaloids -- Synthesis.
- Dartmouth Dissertations
- Spectroscopic and magnetic studies of jack bean urease: pH and buffer effects on the Ni(II) coordination.
- Urease. Urease -- Magnetic properties. Nickel. Hydrolysis. Canavalia ensiformis.
- Dartmouth Dissertations
- Induced optical effects in germanium-doped silica glass.
- Silica, Vitreous -- Optical properties.
- Dartmouth Dissertations
- Detection of hydrocarbons and hydrocarbon microseepage in the Bighorn Basin, Wyoming using isotopic, biogeochemical, and spectral reflectance techniques.
- Hydrocarbons -- Secretion. Petroleum -- Geology -- Bighorn Basin (Mont. and Wyo.). Natural gas -- Geology -- Bighorn Basin (Mont. and Wyo.). Isotope geology -- Bighorn Basin (Mont. and Wyo.). Sagebrush -- Bighorn Basin (Mont. and Wyo.) -- Analysis....
- Dartmouth Dissertations
- Dielectric properties of moist soils at RF and microwave frequencies.
- Soils -- Electric properties. Soil moisture -- Measurement. Dielectrics.
- Dartmouth Dissertations

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