Many alkaloids of biological importance have the 11H-pyrido (4,3,2-mn) acridine ring structure such as cystodytin and amphimedine. It would be desirable to find an effective way to synthesize a wide variety of these compounds using a single...
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
We present results from a modeling effort of simple shock phenomena in the Cygnus Loop and Cassiopeia A. Using multi-epoch MDM observations of a small, isolated cloud in the southwest region of the Cygnus Loop, we measure the velocity of the...
Within a species, the abundance of individuals varies in time and space. This dissertation research examines processes giving rise to patterns of spatial and temporal variation in the abundance of multiple species of forest-breeding migratory...
This thesis describes the development of a cell free system for the study of the organization of microtubules into mitotic asters that lack conventional centrosomes and the use of this system, in combination with in vivo approaches, for the...
Though researchers have advocated a more direct link between individual, population, and community processes, translating the behavior of individuals to the dynamics of natural populations and communities has remained a major challenge in ecology....
Human locomotion -- Computer-assisted instruction. ; Real-time data processing. ; Human-computer interaction.
Teaching physical motions such as riding, exercising, swimming, etc. to human beings is hard. Coaches face difficulties in communicating their feedback verbally and cannot correct the student mid-action; teaching videos are two dimensional and...
Identifying and understanding sources of individual variation in fecundity is of central importance to life history theory and population ecology. In this study, I first examined how factors on the breeding grounds in eastern Maryland affected the...
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
A hallmark of apoptosis is internucleosomal DNA fragmentation catalyzed by an endogenous endonuclease. Many laboratories have implicated the activation of Ca2+/Mg2+-dependent endonucleases or the acid-dependent deoxyribonucleases, (DNase II),...
Electronic mail systems -- Security measures. Electronic mail systems -- Social aspects. Trust.
A secure system that cannot be used by real users to secure real-world processes is not really secure at all. While many believe that usability and security are diametrically opposed, a growing body of research from the field of Human-Computer...
Cellular signal transduction. Transcription factors. cos protein, Drosophila. Medical Terms: Hedgehog Proteins; Signal Transduction -- physiology; ci protein, Drosophila.
The evolutionarily conserved Hedgehog (Hh) signaling pathway is required for proper embryonic patterning and development. Deregulated Hh signaling has been implicated in various human carcinomas and developmental defects, thus elucidation of the...
Epistasis (Genetics) Bioinformatics -- Methodology. Genetics -- Data processing. Medical Term Computational Biology -- methods.
A goal of human genetics is the prediction of an individual's risk of common human diseases from their genome sequence. Currently genome-wide methods to measure genetic variation across individuals exist, but methods to effectively analyze these...
Ovaries -- Cancer -- Photochemotherapy.
Ovaries -- Cancer -- Treatment -- Evaluation.
Ovaries -- Cancer -- Treatment -- Mathematical models.
The translational potential of new therapeutic strategies for cancer is limited, in part, by a lack of biological models that capture important aspects of tumor growth and treatment response. It is also becoming increasingly evident that no single...
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
As the visual effect and movie industries are striving for realism and high fidelity images, physically based lighting, global illumination, realistic materials, and highly tessellated geometry are gradually accepted and used in movie and game...
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
During our fieldwork with real-world organizations---including those in Public Key Infrastructure (PKI), network configuration management, and the electrical power grid---we repeatedly noticed that security policies and related security artifacts...
Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...