Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
The thesis is dedicated to the understanding and characterization of brittle compressive fracture of columnar S2 ice. The work quantifies the strength of fresh-water S2 ice and investigates its characteristic brittle failure modes under biaxial...
Climatic geomorphology -- Sierra Nevada (California and Nevada). ; Slopes (Physical geography) -- Sierra Nevada (California and Nevada). ; Weathering -- Sierra Nevada (California and Nevada). ; Chemical denudation -- Sierra Nevada (California and...
Landscapes evolve in response to external forcings such as climate and tectonics that influence the pace and patterns of erosion and weathering processes. Furthermore, internal feedbacks between erosion and weathering regulate the expression of...
Air -- Pollution. ; Indoor air pollution. ; Air -- Pollution -- Measurement.
The polycyclic aromatic hydrocarbon (PAH) content of ambient air at several locations is described. The indoor sites examined included those having woodstoves, fireplaces, and kerosene heaters as supplements to oil heat, as well as one test home...
2-D and 3-D woven composites are becoming materials of choice for the forming of structural parts for an ever-increasing range of industries from infrastructure to aerospace. Research has shown that for a wide range of structural composites, in...
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
5,6-Azulyne, the first azulyne to be prepared, has been trapped with furan to give an adduct whose crystal structure reveals marked bond alternation in the azulene pi system. The double bond in the furan moiety is responsible in part for the bond...
The matrix metalloproteinases (MMPs) are family of enzymes with a common domain structure that degrade extracellular matrix proteins; these enzymes are overexpressed in numerous diseases including cancer and arthritis. Collagenase-1, 2, 3 (MMP-1,...
Metalorganic chemical vapor deposition (MOCVD) is a complex process. In this thesis, we try to understand the formation mechanism of cadmium (Cd) and cadmium sulfide (CdS) thin films by MOCVD. CdS can be formed from the spontaneous reaction of...
Notables A-B; Han081201-08/12/88; Hanover, N.H.: Bruce Babbitt (right), former Governor (D) of Arizona, spoke at Dartmouth College on 8/11, on what it was like to have been an unsuccessful candidate for President in 1988. Seen talking to N.H....
Ice mechanics. Compressibility. Fracture mechanics. Strains and stresses. Brittleness.
This work describes the effect of triaxial compressive confinement on the strength of columnar S2 ice loaded under conditions leading to brittle failure. Cubes of columnar S2 ice were tested at -10 °C under triaxial (proportional) loading where...
The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space...
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Even though 25 years have passed since the discovery of MYC, a complete understanding of the mechanism(s) of transcriptional control by this oncogenic transcription factor has not been achieved. Mcy is one of the most frequently deregulated...
The unifying theme of this work has been the use of forward genetics to identify three new genes - each thought to play an important yet unrecognized role in either the core circadian oscillator of Neurospora crassa , or in its main physiological...
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
The effects of process parameters on the microstructural and textural evolution during directional recrystallization processing were investigated. Microstructural evolution during primary directional recrystallization of 80% cold-rolled, single...
Metal powders -- Extrusion. Metal powders -- Microstructure. Shear flow.
The manufacture of bulk parts from metastable powder materials requires new approaches to cold consolidation. One potential technique is equal-channel angular extrusion (ECAE), a simple shear process. This thesis describes an investigation into the...
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Recombinant protein production has traditionally relied on organisms with well developed molecular biological tools, such as E. coli. However, E. coli is not suited for large industrial scale production due to its propensity to produce organic...