Studies have implicated the essential role of Vitamin A (VA) and its active metobolite, retinoic acid (RA) in both host defense and tolerance through manipulation of various immune cells, including T cells, B cells, macrophages and others. CD8⁺ T...
Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode...
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Serotonin (5-hydroxytryptamine, 5-HT) in the prefrontal cortex (PFC) plays an important role in cognitive processing and emotional regulation, and altered serotonergic signaling in the cortex is associated with disorders such as schizophrenia,...
Hyperthermia, the elevation of tissue temperature from 42°C to 50°C, is currently being investigated as an adjunct to radiation therapy in the treatment of cancer. The interstitial microwave antenna array hyperthermia (IMAAH) system is designed...
Ciliata -- Effect of sediments on. ; Ciliata -- Effect of habitat modification on. ; Plankton -- Effect of sediments on. ; Plankton -- Effect of habitat modification on.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
An investigation of the mechanical properties of Fe-Al single crystals by tensile testing both at different strain rates (10 -7 s -1 to 1 s -1 ) and in different environments (air, vacuum, or oxygen), showed that moisture-produced hydrogen in Fe-Al...
The opportunistic pathogen Pseudomonas aeruginosa secretes a protein that triggers the accelerated degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. This protein, known as the CFTR inhibitory...
Earth's high latitude ionosphere, highly disturbed by particle and energy inputs and associated aurora, is the stage for plasma wave activity across a wide range of frequencies. These waves often exhibit strikingly distinct time-frequency structure...
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) function as paracrine and autocrine receptors throughout the body. Most studies have focused on their role in fast excitatory neuronal signaling, and learning and memory. In...
Strong evidence exists showing that stellar evolution models are unable to accurately predict the fundamental properties of low-mass stars. Observations of low-mass stars in detached eclipsing binaries (DEBs) indicate that stellar models...
This thesis presents technologies for the design, fabrication, operation, and control of electrostatic MEMS micro-robots. It describes prototype micro-robots, with dimensions of 60 μm by 250 μm by 10 μm, that are capable of controllable...
Ataxia telangiectasia -- Molecular aspects.
DNA damage.
Cell cycle -- Regulation.
Antineoplastic agents.
Cancer cells -- Growth -- Regulation.
Medical Term Cell cycle proteins.
DNA can be damaged by many endogenous and exogenous factors. In response to DNA damage, cells activate cell cycle checkpoints to stop the cell cycle and allow time for repair of the damage. Defects in these pathways allow replication to continue...
We expect wireless body-area networks of pervasive wearable devices will enable in situ health monitoring, personal assistance, entertainment personalization, and home automation. As these devices become ubiquitous, we also expect them to...
Breast -- Magnetic resonance imaging. Breast -- Tomography. Near infrared spectroscopy. Optical tomography. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models.