Study 1 This systematic review aimed to synthesize the emerging body of work on the impact of employment, with a focus on prospective cohort studies. Researchers identified relevant studies for review via PubMed, expert referral, and reference...
Climate change is altering the thermal environment for populations at all trophic levels and thus the response of any given population to warming can only be understood in the context of species interactions. Consumer-resource species interactions...
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
Esterification of cholesterol by acyl-CoA:cholesterol acyltransferase (ACAT) is a key element in maintaining cholesterol homeostasis in cells of higher animals. In the budding yeast, Saccharomyces cerevisiae, accumulation of ergosteryl esters...
Work in Arabidopsis and other model species over the past 25 years has led to major insights into the control of floral organ identity. However, much less is known about genes that control the growth and differentiation of floral organs. In this...
Medicine -- Religious aspects. Health -- Religious aspects. Spirituality -- Health aspects. Spirituality -- Testing. Primary care (Medicine). Patients -- Religious life.
Background . Although the epidemiology of spirituality/religion is still an emerging field, initial research suggests spirituality may promote better health. Additionally, physician-inquiry about spirituality may enhance the quality and possibly...
Muscle proteins. Myosin -- Structure-activity relationships. Kinesin -- Structure-activity relationships. Mechanism of action (Biochemistry). Molecular Motor Proteins.
Protein motors, such as kinesin and myosin, use chemical energy in the form of ATP to physically move along filaments and perform complex mechanical tasks in the cell, such as intracellular transport, cell division and muscle contraction. Myosin...
Microglia -- Effect of drugs on.
Morphine -- Physiological effect.
Purines -- Receptors.
Drug tolerance.
Cell culture -- Technique.
Medical Term Receptors, Purinergic P2 -- physiology.
Chronic pain is a debilitating condition which exacts severe emotional, physical and economic tolls on the millions of people who suffer from it worldwide. Opioids are a mainstay of acute, postoperative and cancer pain therapy, however, their use...
Coal combustion remains an important source of toxic metal emissions. Dilute concentrations and poor understanding of their chemistries hinders reduction of these emissions. This thesis examines the chemistry of the trace metals arsenic and mercury...
Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
The Hedgehog (Hh) and Wnt pathways are key biological signaling pathways responsible for embryonic development, cellular proliferation, stem cell maintenance and self-renewal, and adult somatic tissue homeostasis. Because these pathways serve as...
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Through a series of case studies, signal processing and statistical tools, analyses of dynamic sea ice processes of drift, deformation, and ice pack expansion and decay are investigated for the Weddell Sea region during 1992. Cavitating fluid (CAV)...