Dartmouth Digital Library Program

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Modeling effects of magnetic field line curvature on transient proton belts.
Magnetosphere -- Mathematical models. ; Magnetic fields -- Mathematical models. ; Scattering (Physics) -- Mathematical models.
Lowest order charged particle motion in the Earth''s magnetosphere can be explained using simple adiabatic theory. However, nonadiabatic theory is required to explain particle behavior in cases such as when the particle's gyroradius is large...
Dartmouth Dissertations

Functions of prostacyclin in vascular and uterine smooth muscle.
Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
Dartmouth Dissertations

Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Numerically explicit estimates for character sums
Exponential sums. ; Number theory. ; Numbers Prime. ; Congruences and residues. ; Inequalities (Mathematics)
Dartmouth Dissertations

A model for eclipsing cataclysmic variables.
Cataclysmic variable stars. ; Eclipsing binaries.
Dartmouth Dissertations

The use and transfer of learning strategies in the classroom.
Learning, Psychology of. ; Cognitive styles.
Dartmouth Dissertations

On the poisson relation for lens spaces / by Donato R. Cianci
Motivated by quantum mechanics and geometric optics, it is a long-standing problem whether the length spectrum of a compact Riemannian manifold can be recovered from its Laplace spectrum. One route to proving that the length spectrum depends on the...
Dartmouth Dissertations

I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions; II. Synthesis of pyrrolo[3,4-b]indoles.
Indole -- Synthesis. Indole -- Reactivity. Pyrroles. Diels-Alder reaction.
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Dartmouth Dissertations

A benzonorbornyl model system for the study of carbocation-[pi] interactions.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dartmouth Dissertations

On the first-order amplitude statistics of myocardial ultrasonic backscatter.
Echocardiography -- Mathematical models. ; Backscattering -- Statistics. ; Myocardium.
Dartmouth Dissertations

Diffusion-weighted magnetic resonance imaging with high gradient fields.
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Dartmouth Dissertations

Circadian regulation of gene expression in Arabidopsis thaliana.
Arabidopsis thaliana. ; Circadian rhythms. ; Genetic regulation.
Dartmouth Dissertations

SW Sextantis stars, superhumps, and other phenomena in cataclysmic variables.
Cataclysmic variable stars -- Spectra. ; Stars -- Constitution.
Cataclysmic variable stars are a broad class of close binary systems in which matter is transferred from a normal secondary star onto a white dwarf. This thesis reports spectroscopy of a number of examples, aimed mostly at clarifying the underlying...
Dartmouth Dissertations

Iron acquisition and regulation in Bradyrhizobium japonicum.
Rhizobium -- Physiology. Rhizobium -- Genetics. Plants -- Effect of iron on.
Iron is essential in the agriculturally important symbiosis between Bradyrhizobium japonicum and soybean. Studying iron uptake in B. japonicum presents unique challenges in that the organism is found in two very different environments, free living...
Dartmouth Dissertations

IL-1 regulation of collagenase-3 (MMP-13) gene expression in chondrocytic cells.
Interleukin-1. ; Extracellular matrix proteins -- Metabolism. ; Cartilage cells -- Metabolism. ; Metalloproteinases -- Genetic aspects. ; Collagenases -- Genetic aspects. ; Genetic transcription -- Regulation. ; Chondrocytes
The matrix metalloproteinases (MMPs) are family of enzymes with a common domain structure that degrade extracellular matrix proteins; these enzymes are overexpressed in numerous diseases including cancer and arthritis. Collagenase-1, 2, 3 (MMP-1,...
Dartmouth Dissertations

Perturbation of Eg5 reveals insights into mitotic spindle structure and mechanics.
Spindle (Cell division) Microtubules. Kinesin. Medical Term Molecular Motor Proteins. Microtubule-Associated Proteins.
A pre-requisite for proper health of the cell and the organism is accurate chromosome segregation during cell division. Defects in chromosome segregation lead to aneuploidy, a hallmark of an unstable genome and a frequent attribute of cancer and...
Dartmouth Dissertations

Role of proteolytic processing of tumor necrosis factor-[alpha] in immunopathology during influenza infection / by Matthew Peter DeBerge.
Influenza virus is a respiratory pathogen that is capable of causing considerable pulmonary pathology and respiratory dysfunction in humans. Seasonal influenza epidemics and the occasional influenza pandemic are responsible for significant...
Dartmouth Dissertations

The effect of epileptiform activity and seizures during development on the prefrontal cortex and cognition / by Amanda Erin Hernan.
Epilepsy is the most common neurological disorder in children, with an incidence of 100 per 100,000 children per year. Recurrent seizures during this period in life are often distressing to the individual and the family, but arguably the most...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Sampling for complexity in rendering / by Jiawei Ou.
As the visual effect and movie industries are striving for realism and high fidelity images, physically based lighting, global illumination, realistic materials, and highly tessellated geometry are gradually accepted and used in movie and game...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Crevasse detection in ice sheets using ground penetrating radar and machine learning / by Rebecca M. Williams.
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Automatic spectral classification.
Stars -- Spectra -- Classification. Stars -- Open clusters.
Dartmouth Dissertations

Group 6B metal complexes of three and four membered organic rings.
Organometallic compounds. Transition metal compounds.
Dartmouth Dissertations

C.O.A.L.1: a dynamic model for the analysis of United States energy policy.
Energy policy -- United States -- Mathematical models.
Dartmouth Dissertations

A multivariate analysis of self-selection and change due to college experience.
College students -- Psychology. College environment.
Dartmouth Dissertations

The synthesis and chemistry of novel cyclic perfluoromethyl-substituted molecules.
Fluorine compounds.
Dartmouth Dissertations

Studies of equilibrium and dynamic properties of polymers.
Polymers. Chemical equilibrium.
Dartmouth Dissertations

The effect of microstructure on firn gas transport / by Kaitlin M. Keegan
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Dartmouth Dissertations

Bijective combinatorics of reduced decompositions / by Zachary Hamaker.
We study the bijective combinatorics of reduced words. These are fundamental objects in the study of Coxeter groups. We restrict our focus to reduced words of permutations and signed permutations. Our results can all be situated within the context...
Dartmouth Dissertations

Group-aware stream filtering.
Streaming technology (Telecommunications). Computer networks -- Monitoring. Multicasting (Computer networks). Electronic data processing -- Distributed processing.
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
Dartmouth Dissertations

Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Dartmouth Dissertations

Towards the experimental verification of macroscopic phenomena in quantum electrodynamics.
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

Nerve growth factor and the septohippocampal system / by Lan Guo.
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
Dartmouth Dissertations

The employment of people with severe mental illness / by Alison E. Luciano.
Study 1 This systematic review aimed to synthesize the emerging body of work on the impact of employment, with a focus on prospective cohort studies. Researchers identified relevant studies for review via PubMed, expert referral, and reference...
Dartmouth Dissertations

Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

Molecularly imprinted polymer and applications in nicotine sensing / by Yuan Liu.
Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

Shared decision making for people with severe mental illness.
Mentally ill -- Care -- Decision making. Mental illness -- Treatment -- Decision making. Mental health services -- Decision making. Mental health -- Information services. Medical informatics. Mental Disorders -- drug therapy.
Objective. We explored preferences and perceptions about treatment decision-making roles among persons with severe mental illness and evaluated two computer-based medication values clarification tools. Methods. In this study we conducted a pilot...
Dartmouth Dissertations

The quantum-to-classical transition in strongly interacting nanoscale systems / by Latchezar Latchezarov Benatov.
This thesis comprises two separate but related studies, dealing with two strongly interacting nanoscale systems on the border between the quantum and classical domains. In Part 1, we use a Born-Markov approximated master equation approach to study...
Dartmouth Dissertations

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