This thesis is divided into 2 parts. In the first part of the thesis, we describe a software based approach to speeding up the Magnetic Resonance Imaging modality. In the second part of the thesis, we describe Significance Tree Quantization, which...
Limbic system -- Psychophysiology. ; Neuropsychology. ; Cell interaction.
Previous research has identified neurons in a variety of limbic structures which discharge in relation to the animals ongoing head direction (HD) (Ranck 1984; Taube et al. 1990a) or location (O''Keefe & Dostrovsky 1971). Because these signals...
Electron donor-acceptor complexes. ; Complex compounds. ; Photochemistry.
In this study we have utilized spectroscopic and photoconductivity techniques to investigate free ion formation in the fumaronitrile/trans-stilbene charge transfer-complex. We report free ion yields resulting from the direct excitation of this...
Mitotic apparatuses from sea urchin embryos contain a protein (p62), previously shown to be required for mitotic progression. This protein localizes to the mitotic apparatus during cell division in urchin embryos and mammalian tissue culture cells....
Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
Electric inductors -- Design and construction.;""DC-to-DC converters -- Design and construction."";""Thin film devices -- Design and construction."";""Microfabrication."";""Magnetic films."";""Thin films Multilayered."";""Granular...
Serotonin (5-hydroxytryptamine, 5-HT) in the prefrontal cortex (PFC) plays an important role in cognitive processing and emotional regulation, and altered serotonergic signaling in the cortex is associated with disorders such as schizophrenia,...
Optical tomography. Fluorescence. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models. Brain -- Diseases -- Diagnosis. Brain -- Magnetic resonance imaging.
Fluorescent molecules targeted to reveal information on tissue function have been used as research tools in ex vivo and subsurface characterization of diseased tissue for years. Exploiting this specificity for in vivo imaging through centimeters of...
Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle...
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space...
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Magneto-spectroscopy is used to characterize the confinement properties of strain-induced quantum wires and dots. The wires and dots are low energy regions in an ordinary GaAs/AlGaAs quantum well that are formed when microscopic...
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Magnetic nanoparticles are promising candidates for use in biomedical applications as remote sensors of biophysical properties, thermal therapy agents, and detectors of specific biomolecules. Many approaches have been used to model magnetic...
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Corpus callosum -- Physiology. Cerebral hemispheres. Laterality. Sensorimotor integration. Brain -- Localization of functions.
The overarching goal of the dissertation was to further understanding of the relationship between callosal organization, functional lateralization, and interhemispheric communication in the healthy, young adult brain. Three converging methodologies...