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The experimental analysis of mutlitple computationally-driven methods for the deletion of broadly distributed T cell epitopes in a functional biotherapeutic candidate / by Regina Salvat
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
Dartmouth Dissertations

A benzonorbornyl model system for the study of carbocation-[pi] interactions.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dartmouth Dissertations

Ground-based interferometric studies of auroral roar.
Ionospheric radio wave propagation -- Observations. ; Auroras -- Observations. ; Interferometers -- Design and construction.
Dartmouth Dissertations

Synthesis, characterization, and reactions of octafluorobicyclo[2.2.0]hex-1(4)-ene.
Fluorine compounds -- Synthesis. ; Hexafluorobenzene.
Dartmouth Dissertations

Synthesis and bond alternation of azulene derivatives.
Azulene -- Derivatives -- Synthesis. ; Polycyclic aromatic hydrocarbons -- Synthesis. ; Crystallography. ; Chemical bonds.
5,6-Azulyne, the first azulyne to be prepared, has been trapped with furan to give an adduct whose crystal structure reveals marked bond alternation in the azulene pi system. The double bond in the furan moiety is responsible in part for the bond...
Dartmouth Dissertations

Tube representations of ordered sets.
Partially ordered sets. ; Combinatorial set theory. ; Polytopes.
Dartmouth Dissertations

The regulation of apoptosis by protein phosphatases: impact on intracellular acidification and processing of the retinoblastoma protein.
Apoptosis. ; Phosphoprotein phosphatases. ; Retinoblastoma. ; Immunosuppression.
Dartmouth Dissertations

The role of CD154/CD40 interactions in the development and persistence of CD4+ T cell-mediated immunity.
CD antigens. ; T cells -- Receptors. ; Tumors -- Immunological aspects. ; Mice -- Immunology. ; CD4-Positive T-Lymphocytes. ; Antigens CD40.
The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
Dartmouth Dissertations

Investigations in non-model-based friction estimation and compensation in motion control.
Friction. ; Friction -- Mathematical models. ; Friction -- Computer simulation. ; Motion. ; Machinery Kinematics of. ; Filters (Mathematics). ; Estimation theory.
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
Dartmouth Dissertations

Sex- and region-specific differences in GABA[subscript A] receptor function in neurons of the hypothalamus and forebrain.
GABA -- Receptors. ; GABA -- Physiological effect. ; Sexual behavior in animals. ; Hypothalamus -- Physiology.
The overall goal of this research has been to investigate sex-specific and region-specific differences in the function of the γ-aminobutyric acid type A (GABA[subscript A]) receptor in two regions of the brain which are essential for the...
Dartmouth Dissertations

Stable isotope paleoclimate studies in the western Basin and Range and greater Yellowstone Region.
Orogeny -- Sierra Nevada (California and Nevada). ; Paleoclimatology -- Sierra Nevada (California and Nevada). ; Paleoclimatology -- Montana. ; Paleoclimatology -- Holocene. ; Metamorphism (Geology) -- Pakistan -- Nanga Parbat.
Dartmouth Dissertations

A study of charge transfer in cyanoanthracene/methyl-substituted benzene exciplexes.
Excited state chemistry. ; Photochemistry. ; Charge transfer.
Dartmouth Dissertations

Regulation of the floral organ identity gene APETALA3 in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics. ; Genetic regulation.
APETALA3 (AP3) is a MADS box gene required for normal development of the petals and stamens in the Arabidopsis flower. AP3 transcriptional regulation occurs in two stages; an initial establishment phase, which is mediated by LEAFY (LFY) and UNUSUAL...
Dartmouth Dissertations

The mechanical properties and strain-induced ferromagnetism in B2-structured FeAl single crystals.
Iron-aluminum alloys -- Testing. ; Iron-aluminum alloys -- Mechanical properties. ; Ferromagnetism. ; Strains and stresses.
An investigation of the mechanical properties of Fe-Al single crystals by tensile testing both at different strain rates (10 -7 s -1 to 1 s -1 ) and in different environments (air, vacuum, or oxygen), showed that moisture-produced hydrogen in Fe-Al...
Dartmouth Dissertations

Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
Dartmouth Dissertations

The effects of thyrotropin releasing hormone in the retrotrapezoid nucleus.
Thyrotropin releasing factor -- Physiological effect. ; Pons Varolii -- Physiology. ; Medulla oblongata -- Physiology. ; Respiration -- Regulation. ; Rats -- Respiration.
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Dartmouth Dissertations

Accurate K/Ar dating of and preservation of oxygen in zeolites.
Zeolites. ; Potassium-argon dating. ; Isotope geology.
Dartmouth Dissertations

Factors controlling the seasonal abundance and distribution of Calanus finmarchicus in the Gulf of Maine/Georges Bank Region.
Calanus finmarchicus -- Georges Bank. ; Calanus finmarchicus -- Maine Gulf of. ; Calanus finmarchicus -- North Atlantic Ocean.
Calanus finmarchicus, a kind of marine zooplankton, plays an important ecological role throughout the North Atlantic. Striking seasonal variations exist in its abundance and distribution in the Gulf of Maine/Georges Bank region. On the Bank in...
Dartmouth Dissertations

Biophysical analysis of the role of γc in the assembly of the interleukin-2 receptor.
Interleukin-2. ; T cells -- Receptors. ; Structure-activity relationships (Biochemistry). ; Biophysics.
Dartmouth Dissertations

Cloning and expression of HVACM, a cullin protein, from small cell lung cancer.
Vasopressin -- Receptors. ; Small cell lung cancer. ; Genetic regulation. ; Molecular cloning. ; Immunohistochemistry.
Dartmouth Dissertations

Retrieval, reconstruction, and response bias: a cognitive neuroscience investigation of false memories.
False memory syndrome. ; Cognitive neuroscience. ; Prefrontal cortex -- Physiology.
Our conscious experience of memory often includes reconstuctions of the past in order to fill the gaps of forgotten events and details. The goal of this thesis is to use the tools of cognitive neuroscience to better understand the cognitive and...
Dartmouth Dissertations

Synthetic approaches to the azamacrolides [Part] I; Synthetic approaches to carbazoles and 2-acylindoles [Part] II.
Alkaloids -- Synthesis. ; Allomones. ; Indole. ; Carbazone. ; Diels-Alder reaction.
A novel synthetic route to the synthesis of 9-propyl-10-azacyclododecan-12-olide (1), a natural allomone isolated from the Mexican bean beetle pupa, is presented. The salient features of this synthetic route are a regioselective Beckmann...
Dartmouth Dissertations

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