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- The importance of dosage of core binding factors α and ß in hematopoietic development.
- Hematopoiesis -- Regulation. ; Transcription factors.
- Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
- Dartmouth Dissertations
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- posted on Flickr, The Second College Grant lies ab...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- First Year Trip - 2nd College Grant: Beyond Hanove...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: The Second College Grant lies about...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- College Grant: posted on Flickr, The Second Colleg...
- Dartmouth College Photographic Records
- Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
- Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
- Dartmouth Dissertations
- Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
- Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
- Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
- Dartmouth Dissertations
- Regulation of B lymphocyte proliferation and differentiation through CD40.
- B cells. CD antigens. Immune response -- Regulation.
- Dartmouth Dissertations
- Investigation of the reactivity of vinylimidazoles.
- Imidazoles. ; Heterocyclic compounds -- Synthesis.
- Dartmouth Dissertations
- CXCR3 and its cognate-chemokine expression : implications for cancer immunotherapy / by Eleanor Clancy-Thompson
- Despite immunogenicity, melanoma-specific vaccines have demonstrated minimal clinical efficacy in patients with established disease, but enhance survival when administered in the adjuvant setting. It has been shown that T cell infiltration of...
- Dartmouth Dissertations
- The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
- Partially ordered sets. ; Forcing (Model theory). ; Set theory.
- Dartmouth Dissertations
- Glucocorticoids affect the action of gamma interferon on human monocytes.
- Glucocorticoids. ; Interferon. ; Monocytes. ; Immunity.
- Dartmouth Dissertations
- Computer based electron beam treatment planning.
- Radiotherapy. ; Electron beams. ; Computers.
- Dartmouth Dissertations
- On the leukemogenic mechanisms of core binding factor translocation products.
- Transcription factors -- Pathophysiology. Myeloid leukemia -- Genetic aspects. Genetic transcription -- Regulation.
- Core binding factor translocations and inversions are among the most frequently identified mutations in acute myeloid leukemia. We present work that characterizes the functional contributions of domains within the fusion proteins resulting from the...
- Dartmouth Dissertations
- Hormonal and neurochemical determinants of sex differences in chronic radicular pain.
- Radiculitis -- Endocrine aspects. Radiculitis -- Sex factors. Radiculitis -- Pathophysiology. Pain -- Sex factors. Progesterone -- Physiological effect. Cellular signal transduction. Neuregulin-1 -- physiology.
- Chronic low back pain is a debilitating and devastating disease affecting millions of people worldwide. Considerable evidence indicates that there are sex-related differences in clinical and experimental pain sensitivity in men and women. Women...
- Dartmouth Dissertations
- Regulation of human monocyte CD163 during the innate immune response to infection.
- CD antigens. Immune response -- Regulation. Hemoglobin.
- CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
- Dartmouth Dissertations
- Characterization of novel cofactors for oncogenic transcription factors Myc and FoxM1 and cytotoxic peptides derived from an essential Myc domain.
- Transcription factors -- Genetics. Carcinogenesis. Peptides. Cell cycle -- Regulation. Genetic regulation. Medical Terms: Genes, myc -- genetics; Forkhead Transcription Factors -- genetics; Neoplasm Proteins -- genetics; Trans-Activators --...
- Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
- Dartmouth Dissertations
- Unraveling mechanisms underlying myeloid-derived suppressor cell orchestration of ovarian cancer progression
- Suppressor cells -- Cellular immunity. -- Interleukin-10 -- Pathophysiology -- Ovaries -- Cancer -- Immunological aspects. -- Myeloid cells -- immunology -- Ovarian Neoplasms -- immunology.
- Dartmouth Dissertations
- Regulation of CD8+ T cell immunity by retinoic acid / by Yanxia Guo.
- Studies have implicated the essential role of Vitamin A (VA) and its active metobolite, retinoic acid (RA) in both host defense and tolerance through manipulation of various immune cells, including T cells, B cells, macrophages and others. CD8⁺ T...
- Dartmouth Dissertations
- Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
- Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
- Dartmouth Dissertations
- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations
- System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
- Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
- Dartmouth Dissertations
- Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
- Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
- Dartmouth Dissertations
- The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
- Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
- Dartmouth Dissertations
- The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
- Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
- Dartmouth Dissertations
- MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
- The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
- Dartmouth Dissertations
- Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
- Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
- Dartmouth Dissertations
- A photoexcited three-component electron-hole plasma in type II GaAs/AlAs quantum wells.
- Electron-hole droplets. Plasma (Ionized gases). Quantum wells.
- Dartmouth Dissertations
- ID4 promotes the growth of glioblastoma multiforme by mediating MGP-enhanced angiogenesis.
- Glioblastoma multiforme. DNA-binding proteins. Transcription factors. Extracellular matrix proteins. Neovascularization.
- ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
- Dartmouth Dissertations
- Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
- T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
- Dartmouth Dissertations
- Dendritic cell Fcγ receptor expression and function
- Fc receptors. Dendritic cells. Immune recognition.
- Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
- Dartmouth Dissertations
- Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
- Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
- To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
- Dartmouth Dissertations

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