APETALA3 (AP3) is a MADS box gene required for normal development of the petals and stamens in the Arabidopsis flower. AP3 transcriptional regulation occurs in two stages; an initial establishment phase, which is mediated by LEAFY (LFY) and UNUSUAL...
Outcome assessment (Medical care). ; Aortic valve -- Surgery -- Complications. ; Aortic valve -- Surgery -- New England. ; Cardiovascular instruments Implanted.
Aortic valve disease is a frequent and serious disorder. Although aortic valve replacement (AVR) is arguably the only effective treatment, important issues remain unresolved in the care of patients with this disease. Recent studies have focused...
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
The eukaryotic flagellum is a complex organelle that uses the force generated by dynein motors to cause beating motion of the flagellum. The central apparatus of eukaryotic flagella has been implicated in the regulation of dynein-driven motility....
In this thesis we look at several problems that lie in the intersection between combinatorial and multiplicative number theory. A common theme of many of these problems are estimates for and properties of the smooth numbers, those integers not...
The brain is a vastly interconnected information processing network. In humans, this network supports the rich mental space at the root of the imagination and enables many flexible cognitive abilities such as scientific and artistic creativity. How...
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Whistler-mode chorus waves have recently drawn tremendous attention as an important mechanism for controlling the energetic electron flux in Earth’s radiation belt. This dissertation aims to answer questions about whistler-mode chorus waves, such...
The Maine Coastal Current (MCC) flows south-westward along the New England coast in the Gulf of Maine. Red tides, river-borne pollutants, and biological species are hypothesized to be transported by the MCC. The transport pathways, and their...
The docking and fusion of cellular membranes plays an essential role in the secretory and endocytic pathways and in organelle inheritance. The homotypic fusion of vacuoles from the yeast Saccharomyces cerevisiae has been used as a model system to...
Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/O requirements of parallel scientific applications. Most multiprocessor file systems provide...
The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
Vesicle mediated intracellular transport through the secretory pathway requires the formation of transport vesicles from a donor compartment followed by vesicle tethering and fusion with an appropriate acceptor compartment. The anterograde...