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- Damage identification in smart structures through sensitivity enhancing control.
- Structural control (Engineering). ; Smart structures -- Vibration. ; Strains and stresses -- Computer simulation. ; Automatic control -- Sensitivity. ; Feedback control systems.
- This thesis investigates vibration-based damage identification problems in smart structures. Vibration-based damage metrics suffer from small sensitivity of modal properties to damage, thus making it difficult to detect, locate, and determine the...
- Dartmouth Dissertations
- Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
- Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
- Dartmouth Dissertations
- The Kosovo-Dartmouth Alliance for Healthy Newborns...
- 2006-08-25_medicine
- Dartmouth College Photographic Records
- Investigation, optimization and synthesis of dihydrodipyrrins, linear tetrapyrroles and the resulting chlorins.
- Porphyrins -- Synthesis. Tetrapyrroles -- Synthesis.
- The synthesis of macrocyclic tetrapyrroles continues to be an area of vigorous research due to their application to a wide range of fields spanning the physical sciences. Only recently have general syntheses for the reduced systems, such as...
- Dartmouth Dissertations
- The role of tocopherol (vitamin E) in rotifer ecology.
- Rotifera. ; Vitamin E.
- Dartmouth Dissertations
- Improvement and evaluation of nonlinear inversion MR elastography / by Matthew D. J. McGarry.
- Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
- Dartmouth Dissertations
- Caitlin Barthelmes, Director of the Student Wellne...
- Dartmouth College Photographic Records
- Posted july 19, 2016 on Dartmouth News, Beekeeping...
- Dartmouth College Photographic Records
- Posted july 19, 2016 on Dartmouth News, Beekeeping...
- Dartmouth College Photographic Records
- Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
- A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
- Dartmouth Dissertations
- Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
- The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
- Dartmouth Dissertations
- Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
- Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
- Dartmouth Dissertations
- Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
- Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
- Dartmouth Dissertations
- Facial expressions and identity as social cues for biologically relevant learning
- Facial expression.; Threat (Psychology) ; Amygdaloid body -- Psychophysiology. ; Learning Psychology of. ; Memory. ; Attention.
- The experiments comprising this thesis aimed to characterize the neural and behavioral correlates of learning about and responding to the predictive information conveyed by social cues. Facial expressions are cues that convey critical information...
- Dartmouth Dissertations
- Microwave tomographic imaging using dielectric contrast in temperature and tissue content
- Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.
- Dartmouth Dissertations
- Nonstigmatized individuals' reactions to the acknowledgment and valuation of a stigma by overweight individuals and physically disabled individuals.
- Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
- In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
- Dartmouth Dissertations
- Mesh-Mon: a monitoring and management system for wireless mesh networks.
- Wireless communication systems. Computer networks. Routers (Computer networks).
- A mesh network is a network of wireless routers that employ multi-hop routing and can be used to provide network access for mobile clients. Mobile mesh networks can be deployed rapidly to provide an alternate communication infrastructure for...
- Dartmouth Dissertations
- Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
- Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
- Dartmouth Dissertations
- Subtypes of developmental prosopagnosia : behavioral and neural evidence / by Hua Yang
- Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
- Dartmouth Dissertations
- CD8 T cell responses to murine gamma-herpesvirus 68: viral persistence shapes the immune response.
- T cells. Immunologic memory. Latent virus diseases -- Immunological aspects. Herpesvirus diseases. Cell-mediated cytotoxicity. CD8-Positive T-Lymphocytes -- immunology. T-Lymphocytes
- Vaccines are one the greatest advances in public health. Vaccines work by priming cells of the adaptive immune system in such a way that they remember that they have encountered a specific antigen before. This then allows those cells to respond...
- Dartmouth Dissertations
- The study of an endonuclease and its potential role in apoptosis.
- Deoxyribonucleases. ; Endonucleases. ; Apoptosis.
- Previous work in this laboratory has implicated deoxyribonuclease II (DNase II) as an endonuclease responsible for DNA digestion during apoptosis. The goal of this thesis was to isolate the cDNA encoding DNase II and study its potential role in...
- Dartmouth Dissertations
- Studies on the syntheses of bis-pyridocarbazoles and derivatives of ellipticine.
- Pyridocarbazoles. ; Ellipticine. ; Cancer -- Research.
- Dartmouth Dissertations
- Isolation and characterization of Chinese hamster ovary cell lines possessing abnormal LDL-derived cholesterol trafficking.
- Cholesterol. ; Mutation (Biology). ; Low density lipoproteins. ; Cell lines.
- Dartmouth Dissertations
- Chimeric NKG2D receptor expressing T cells as immunotherapy for cancer.
- T cells -- Receptors. Killer cells. Cell-mediated cytotoxicity. Cancer -- Immunotherapy.
- Despite advances in standard treatment options such as surgery, chemotherapy, and radiation, cancer remains the second leading cause of death in the United States. Moreover, many current therapies result in adverse effects. Therefore the...
- Dartmouth Dissertations
- The influence of trait psychopathy on the decoding, interference and utilization of emotional information.
- Psychopaths. Personality and emotions. Emotions and cognition.
- Research investigating clinical and criminal psychopaths is quite extensive. Though it has evolved in terminology over the years, the basic premise and description of psychopathy has maintained deficits associated with emotional interpretation and...
- Dartmouth Dissertations
- The role of lysosomal cysteine proteases in endocytosis-mediated retinal degeneration
- Many retinal degenerative diseases result in blindness. The causes and clinical progression of these diseases are heterogeneous in nature. In many instances the genes involved are known, yet the molecular mechanisms leading to blindness still...
- Dartmouth Dissertations
- Novel methods for improved identification throughput and high-resolution scoring for proteomics
- The field of proteomics aims to identify and quantify the protein contents of a biological sample. The mass spectrometer is the instrument of choice to characterize these proteins. In the typical proteomics experiment, mass spectra are collected...
- Dartmouth Dissertations
- Secondhand-smoke exposure affects the risk of cardiovascular disease / by Jennifer Carol Davey.
- Secondhand cigarette smoke (SHCS) is a serious pollutant that significantly increases the risk for cardiovascular disease (CVD) in millions of people worldwide. A large proportion of those exposed to SHCS are children. Female C57B16 mice were...
- Dartmouth Dissertations
- Role of proteolytic processing of tumor necrosis factor-[alpha] in immunopathology during influenza infection / by Matthew Peter DeBerge.
- Influenza virus is a respiratory pathogen that is capable of causing considerable pulmonary pathology and respiratory dysfunction in humans. Seasonal influenza epidemics and the occasional influenza pandemic are responsible for significant...
- Dartmouth Dissertations
- Functional connectivity of brain reward circuitry in patients with schizophrenia and cannabis use disorder : effects of cannabis and delta-9-tetrahydrocannabinol (THC) / by Adina Sheri Fischer.
- Up to 43% of patients with schizophrenia suffer from a co-occurring cannabis use disorder (CUD), which results in symptom exacerbation, decreased response to antipsychotic medication, and an overall worsening of disease course. Available treatments...
- Dartmouth Dissertations
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Press Translations, Japanese
- Tokyo, Japan
- Press Translations, Japan, 1945-1946
- Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
- Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
- Dartmouth Dissertations
- Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
- Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
- Dartmouth Dissertations
- Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
- Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
- Dartmouth Dissertations
- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
- Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
- Dartmouth Dissertations
- The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
- Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
- Dartmouth Dissertations
- Chemico-physical and pharmacologic factors that influence delivery of IONPs to tumors in rodent breast cancer models / by Jennifer Tate.
- Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations
- Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
- Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
- Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
- Dartmouth Dissertations
- Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
- Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
- Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
- Dartmouth Dissertations
- Analysis of zooplankton dynamics: case studies of temporal succession controlled by the predator, Asplancha, and of diel cycles in Keratella.
- Freshwater zooplankton. Predation (Biology).
- Dartmouth Dissertations
- Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
- The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
- Dartmouth Dissertations
- Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
- Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
- Dartmouth Dissertations
- Characterization of an inducible model of a genetic prion disease in Drosophila melanogaster / by Archana Murali.
- Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration. In humans, these disorders include Creutzfeldt-Jakob disease, kuru and...
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
- Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
- Dartmouth Dissertations
- SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
- Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
- Dartmouth Dissertations
- Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
- PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
- Dartmouth Dissertations

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