Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
The objective of this thesis was to examine the neural and physiological substrates underlying the processing of aversive information, and how individual differences in anxiety influence these responses. In a series of experiments, we utilized skin...
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Electric fields in the high-latitude regions of Earth's ionosphere are an important component of the coupled magnetosphere-ionosphere-thermosphere system. Characterizing the average behavior of these fields (or the corresponding drifts) is useful...
Brain -- Physiology -- Mathematical models.
Brain stem -- Effect of chemicals on.
Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
While anthropogenic emissions of the toxic element mercury (Hg) to the atmosphere are currently rising, major uncertainties remain in determining the relative impacts of anthropogenic activity and natural processes on the global Hg cycle. In this...
The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space...
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Two experiments were designed to investigate the effects of brain damage on source monitoring. Source monitoring is the process of making decisions about the origins of memories. Previous research has demonstrated that source monitoring judgments...
Perceptual-motor learning -- Physiological aspects. ; Language acquisition -- Physiological aspects. ; Motor ability -- Physiological aspects. ; Knots and splices.
The studies presented in this dissertation explore several points of intersection between action perception and production within the human brain. One's ability to use perceptual information about another individual's actions to guide and inform...
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
Angiogenesis is part of the natural defense mechanism in brain against hypoxia and ischemia. Animal models and methods for the non-invasive investigation of cerebral angiogenesis are needed. This thesis addresses the hypothesis that steady state,...
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
The ability to resist highly tempting reward impulses is a struggle that all humans face on a daily basis, one that gives rise to many societal problems such as obesity and drug addiction. This form of self-regulation involves a critical balance...
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
In this thesis we study 1=k-geodesics, those closed geodesics that minimize on any subinterval of length L=k, where L is the length of the geodesic. These curves arise as critical points of the uniform energy, a function introduced in Morse theory...
The discovery of the Van Allen radiation belts in the 1958 was the first major discovery of the Space Age. There are two belts of energetic particles. The inner belt is very stable, but the outer belt is extremely variable, especially during...
One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
Whistler-mode chorus waves have recently drawn tremendous attention as an important mechanism for controlling the energetic electron flux in Earth’s radiation belt. This dissertation aims to answer questions about whistler-mode chorus waves, such...
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Electroencephalography -- Data processing. ; Epilepsy -- Diagnosis. ; Signal processing -- Mathematics. ; Time-series analysis. ; Wavelets (Mathematics).
Visual interpretation of the EEG associated with an epileptic seizure (ictal EEG) can be cumbersome and sometimes misleading, due to rapid seizure spread, limited spatial resolution and the fact that signals of interest are often obscured by...
This dissertation explores the spatial and temporal distributions of impurities in natural ice. Using polarized light, ion chromatography (IC), synchrotron x-ray topography (SXT), scanning electron microscopy (SEM), and energy-dispersive...
Plasma instabilities. ; Ionospheric electron density. ; Ionosphere.
As a result of an unstable plasma stratification the nighttime equatorial ionosphere is subject to a variety of plasma instabilities known commonly as equatorial spread-F. In its fully developed form spread-F consists of large wedges of depleted...
Corpus callosum -- Physiology. Cerebral hemispheres. Laterality. Sensorimotor integration. Brain -- Localization of functions.
The overarching goal of the dissertation was to further understanding of the relationship between callosal organization, functional lateralization, and interhemispheric communication in the healthy, young adult brain. Three converging methodologies...
Van Allen radiation belts -- Mathematical models. Electrons -- Diffusion -- Mathematical models. Magnetohydrodynamic waves -- Mathematical models.
It is becoming increasingly important to understand the dynamics of radiation belt energetic particles given their potentially hazardous effects on satellites and our ever-increasing dependence on those satellites. There is a need to determine...
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...