Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Serotonergic and non-serotonergic neurons located in the medullary raphe region of the mammalian brainstem are involved in numerous physiological processes. Concerning respiration, neurons in this region have been found to be chemosensitive, i.e.,...
Angiogenesis is part of the natural defense mechanism in brain against hypoxia and ischemia. Animal models and methods for the non-invasive investigation of cerebral angiogenesis are needed. This thesis addresses the hypothesis that steady state,...
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Optical spectroscopy. Magnetic resonance imaging. Breast -- Cancer -- Imaging.
Magnetic Resonance (MR)-guided Diffuse Optical Imaging is an emerging technique to improve breast cancer imaging. This modality combines the high sensitivity of breast MR with images of tissue physiology, including blood content, oxygen saturation,...
Brain -- Physiology -- Mathematical models.
Brain stem -- Effect of chemicals on.
Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Sodium cotransport systems.
Chemoreceptors.
Respiration -- Regulation -- Genetic aspects.
Brown garden snail -- Respiration.
Carbon dioxide in the body.
Arginine.
Antisense DNA -- Genetics.
Studies of central CO 2 chemosensors are hampered by the complexity of mammalian central nervous systems. Our laboratory developed the pulmonate snail, Helix aspersa , as a relatively simple alternative to mammalian models. A question concerning...
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral...