Dartmouth Digital Library Program

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Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
Dartmouth Dissertations

Temporal regulation of microRNA expression during animal development.
RNA. Cells -- Growth -- Regulation. Caenorhabditis elegans -- Genetics. Caenorhabditis elegans -- Development. Drosophila melanogaster -- Genetic aspects. Drosophila melanogaster -- Development. Neurons -- Growth. Animal genetics.
MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
Dartmouth Dissertations

Actions of substances placed in the cat cerebrospinal fluid space.
Pharmacology, Experimental. ; Cats.
Dartmouth Dissertations

Regulation of human monocyte CD163 during the innate immune response to infection.
CD antigens. Immune response -- Regulation. Hemoglobin.
CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
Dartmouth Dissertations

Causes and consequences of DeltaNp63 expression in mammary epithelial progenitors.
Epithelium -- Tumors -- Genetic aspects. p53 antioncogene -- Regulation. Stem cells. Breast -- Cancer -- Genetic aspects. Breast -- Cancer -- Etiology. Medical Terms: TP63 protein, human; Tumor Suppressor Proteins -- genetics; Breast Neoplasms --...
Efforts to elucidate the events that account for breast cancer initiation have focused sharply on a small subset of mammary epithelial cells, referred to in this document at mammary stem cells, whose features may enable them to accumulate and...
Dartmouth Dissertations

Nuclear asynchrony and ploidy variation in the multinucleate fungus ashbya gossypii
Classic studies demonstrated that when cells in different cell cycle phases are fused, nuclei cohabiting in a common cytoplasm synchronize their division cycles. Cytoplasmic factors, now known to be cyclin/cyclin dependent kinase (CDK) complexes,...
Dartmouth Dissertations

The sturucture and function of brain networks underlying self-evaluation / by Robert S. Chavez
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
Dartmouth Dissertations

c-di-GMP mediated regulation of the LapA biofilm adhesin through proteolysis by the calcium-dependent cysteine protease LapG / by Chelsea D. Boyd.
The localization of the putative adhesin LapA to the cell surface is a key regulatory step required by Pseudomonas fluorescens Pf0-1 to irreversibly attach to a surface and form a biofilm. LapA contains several domains conserved in predicted...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

ACAT1 in macrophage as a potential target for atherosclerosis and for diet induced obesity / by Li-Hao (Paul) Huang.
Acyl-CoA: cholesterol acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. There are two isoenzymes, ACAT1 and ACAT2. Here I performed biochemical analyses of individual amino acids within c-terminal loop of ACAT1 and showed...
Dartmouth Dissertations

Rapamycin and adiponectin in vascular smooth muscle cells : implications in the development of drug-eluting stents
Stents (Surgery);Coronary arteries -- Stenosis -- Relapse -- Prevention -- Vascular smooth muscle -- Differentiation."";""Rapamycin."";""Drug delivery devices."";""Drug-Eluting Stents."";""Coronary Restenosis -- prevention &...
Statement of the problem. Drug-eluting stents (DES) dramatically reduce the incidence of coronary restenosis, a frequent complication of percutaneous coronary interventions in the treatment of obstructive arterial diseases. However, they have been...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Determinants of competitive outcome between rotifers and cladocerans.
Cladocera. ; Rotifera. ; Competition (Biology).
Dartmouth Dissertations

Cell cycle characteristics of a microtubule-associated protein that is a component of the mitotic apparatus.
Phosphoproteins. ; Microtubules. ; Mitosis. ; Tubulins.
Dartmouth Dissertations

Characterization of cancer risk and response to immunotherapy through pathway-based genomic analyses / by David C. Qian
For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
Dartmouth Dissertations

Role of GATA-1 in β-globin locus chromatin structure reorganization and eryrhoid [i.e. erythroid] gene expression.
Chromatin -- Structure. Globin genes -- Expression. Transcription factors. Erythropoiesis. Genetic transcription -- Regulation.
Despite being cloned over twenty years ago, many regulatory mechanisms of the β-globin genes have yet to be fully elucidated. The regulation of the β-globin locus in erythroid cells requires chromatin structural changes before the genes can be...
Dartmouth Dissertations

Immunomodulation and the prevention of pathogen-driven ileitis.
Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
Dartmouth Dissertations

Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
Dartmouth Dissertations

Post-translational modification in retinoid action: a role for UBEIL in cancer therapy and chemoprevention.
Retinoids -- Mechanism of action. ; Post-translational modification. ; Tretinoin -- Therapeutic use. ; Lungs -- Cancer -- Chemoprevention.
The retinoids--natural and synthetic derivatives of vitamin A--are active in cancer therapy and chemoprevention. The signals that underlie retinoid clinical activity are triggered by induction of retinoid target genes. Therefore, a greater...
Dartmouth Dissertations

The expression and activity of TP63 in the mammary epithelial regenerative hierarchy.
Tumor proteins. ; p53 antioncogene. ; Epithelial cells. ; Mammary glands -- Cytology. ; Stem cells. ; Regeneration (Biology). ; Genetic transcription -- Regulation. ; Cellular signal transduction.
Dartmouth Dissertations

Host immune responses in a non replication model of Toxoplasma gondii infection.
Toxoplasmosis -- Immunotherapy. Toxoplasma gondii -- Pathophysiology. Immune response -- Regulation.
Toxoplasma gondii is a highly successful obligate intracellular parasite capable of infecting humans and poses a significant health threat to people with AIDS and who are immunosuppressed. Infection with T. gondii involves a highly complex...
Dartmouth Dissertations

5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Contributions of retrosplenial cortex to associative learning and memory.
Cerebral cortex -- Psychophysiology. Learning.
Neuroanatomical studies have defined two relatively separate corticohippocampal processing streams that contribute substantially to medial temporal lobe function. Among the cortical regions providing significant input to these processing streams is...
Dartmouth Dissertations

Bethanechol and central respiratory control.
Bethanechol. ; Anesthetics.
Dartmouth Dissertations

Transgenic cyclin E murine models as discovery tools for lung cancer biology, therapy, and prevention.
Lungs -- Cancer -- Genetic aspects. ; Cyclins -- Pathophysiology. ; Transgenic mice. ; Pharmacogenomics. ; Cyclin E -- genetics.
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Novel inhibitors of MMP-1 and MMP-13 gene expression as potential therapies for arthritis.
Collagenases -- Genetic aspects. Collagenases -- Pathophysiology. Metalloproteinases -- Genetic aspects. Metalloproteinases -- Pathophysiology. Transcription factors. Extracellular matrix proteins. Cartilage -- Diseases. Arthritis -- Genetic...
Matrix metalloproteinases (MMPs) are a family of endopeptidases that collectively degrade all components of the extracellular matrix (ECM) at neutral pH. During the progression of arthritis, MMPs mediate the degradation of cartilage, which consists...
Dartmouth Dissertations

On the origins of cancer cell identity : epigenetic deregulation of cellular states / by Kevin Johnson
The identification of molecular alterations present in cancer is critical to better understand carcinogenesis as well as the clinical trajectories of patients with malignant tumors. Early detection and application of appropriate treatment...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Potential precursors of sulfur monoxide.
Sulfur compounds.
Dartmouth Dissertations

Molecular analysis of novel ER membrane proteins important for homeostasis in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Biological transport -- Regulation. Proteins -- Biodegradation. Proteins -- Synthesis -- Regulation. Endoplasmic reticulum. Cellular control mechanisms. Saccharomyces cerevisiae -- Molecular aspects.
Endoplasmic reticulum (ER) homeostasis requires the coordination of anabolic and catabolic activities. A primary function of the ER is the biosynthesis and export of secretory proteins and lipids. Anterograde transport of only properly folded and...
Dartmouth Dissertations

Exploring the role of CD4 T cell help in the generation of CD8+T cell responses against acute and persistent viral infections
T cells -- Receptors. ; Immunologic memory. ; CD8-Positive T-Lymphocytes -- immunology. ; CD4-Positive T-Lymphocytes -- immunology. ; Vaccinia virus -- immunology. ; Herpesviridae Infections -- immunology.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Cortical representations of hierarchical category learning / by Sergey Victor Fogelson
Current theories of visual category learning posit a representation of category rules and visual features that critically define those categories that are encoded separately and distributed throughout the cerebral cortex. Neuroimaging and...
Dartmouth Dissertations

Mapping the junction of action perception and production.
Perceptual-motor learning -- Physiological aspects. ; Language acquisition -- Physiological aspects. ; Motor ability -- Physiological aspects. ; Knots and splices.
The studies presented in this dissertation explore several points of intersection between action perception and production within the human brain. One's ability to use perceptual information about another individual's actions to guide and inform...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Chronology of Neogene tectonics in the Central Andes (27°-33° S) of western Argentina based on the magnetic polarity stratigraphy of foreland basin sediments.
Geology, Stratigraphic -- Neogene. ; Plate tectonics -- Argentina. Geology -- Argentina.
Dartmouth Dissertations

Unraveling mechanisms underlying myeloid-derived suppressor cell orchestration of ovarian cancer progression
Suppressor cells -- Cellular immunity. -- Interleukin-10 -- Pathophysiology -- Ovaries -- Cancer -- Immunological aspects. -- Myeloid cells -- immunology -- Ovarian Neoplasms -- immunology.
Dartmouth Dissertations

Subtypes of developmental prosopagnosia : behavioral and neural evidence / by Hua Yang
Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

An analysis of the locomotive stimulant and the ECoG effects of L-DOPA.
L-dihydroxphelylalanine. ; Amphetamines.
Dartmouth Dissertations

The effects of endocrine disruptors on the development of Xenopus embryos.
Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
Dartmouth Dissertations

Functional connectivity of brain reward circuitry in patients with schizophrenia and cannabis use disorder : effects of cannabis and delta-9-tetrahydrocannabinol (THC) / by Adina Sheri Fischer.
Up to 43% of patients with schizophrenia suffer from a co-occurring cannabis use disorder (CUD), which results in symptom exacerbation, decreased response to antipsychotic medication, and an overall worsening of disease course. Available treatments...
Dartmouth Dissertations

Immunotherapy of B-cell malignancies: directing T-cell responses and blocking lineage-specific survival factor pathways.
B cells -- Tumors. ; Cancer -- Immunotherapy. ; T cells. ; CD antigens.
The indolent B-cell malignancies of lymphoma and myeloma account for a great number of adult cancers in the United States annually. Hi-dose combination chemotherapy, bone marrow transplants and monoclonal antibody therapeutics have improved the...
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

Modulating innate and adaptive immunity in the Toxoplasma gondii-induced model of inflammatory bowel disease.
Toxoplasma gondii -- Immunology. Inflammatory bowel diseases -- Immunological aspects. C-reactive protein. T cells. Immune response -- Regulation. Protein precursors -- Immunology.
Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
Dartmouth Dissertations

Regulation of peripheral tolerance by mast cells.
Mast cells -- Immunology. Mast cells -- Physiology. Dendritic cells. Immunological tolerance -- Molecular aspects. Medical Term Cell Degranulation.
Mast cells (MC) have until recently been regarded as pro-inflammatory, however this view changed with the observation that the absence of MC impairs the development of transplant tolerance to allografts. However, little is known about whether MC...
Dartmouth Dissertations

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