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Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

Samson Occom, letter, to Eleazar Wheelock, 1 July 1769
1769-07-01. [769401]
[none]
Manuscripts Related to Samson Occom and Eleazar Wheelock's Early Indian Students

Samson Occom, letter, to Eleazar Wheelock, 25 September 1761
1761-09-25. [761525]
[none]
Manuscripts Related to Samson Occom and Eleazar Wheelock's Early Indian Students

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Reactor design considerations for the conversion of particulate biomass to ethanol.
Bioreactors -- Design and construction. Alcohol as fuel. Biomass energy.
Dartmouth Dissertations

The effects of brain damage on source monitoring.
Brain damage -- Psychological aspects. Memory. Brain -- Localization of functions. Neuropsychology.
Two experiments were designed to investigate the effects of brain damage on source monitoring. Source monitoring is the process of making decisions about the origins of memories. Previous research has demonstrated that source monitoring judgments...
Dartmouth Dissertations

Characterization of proteins that bind the conserved LVb and core sequences of mammalian type C retroviral enhancers.
Proteins. Protein binding. Mouse leukemia viruses. Retroviruses.
Dartmouth Dissertations

The influence of spatial expectancy on spatial discriminability in single- and multiple-element displays.
Visual discrimination. ; Visual perception. ; Information display systems -- Psychological aspects.
Dartmouth Dissertations

In vivo fluorescence imaging and tomography methods to quantify metastatic burden in lymph nodes / by Alisha Viola DSouza
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Dartmouth Dissertations

A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
Dartmouth Dissertations

Patient outcomes and decision making in the treatment of hypoplastic left heart syndrome.
Congenital heart disease in children -- Surgery -- Evaluation. ; Heart -- Abnormalities -- Surgery -- Evaluation. ; Outcome assessment (Medical care).
Hypoplastic left heart syndrome (HLHS) is a heart malformation that requires surgical intervention for survival. Without surgery, 95% of neonates with HLHS die in the first month of life. Two surgical approaches are available, a series of...
Dartmouth Dissertations

Intramembranous particle clusters and cytoplasmic vesicles in mice with nephrogenic defects of urinary concentration.
Diabetes -- Research. ; Mice as laboratory animals.
Dartmouth Dissertations

Inhibitory effects of cyanobacteria on zooplankton and their implications for community structure.
Cyanobacteria -- Toxicology. ; Freshwater zooplankton. ; Cyanobacterial blooms -- Toxicology.
Dartmouth Dissertations

Differentiating and anti-inflammatory activities of the triterpenoid, CDDO: interactions with transcription factors PPARγ and NF-κ B.
Triterpenoid saponins -- Physiology. ; Cell receptors. ; Receptor-ligand complexes. ; NF-kappa B (DNA-binding protein). ; Peroxisomes. ; Nucleophilic reactions. ; Dithiole.
Dartmouth Dissertations

Regulation of arabidopsis catalase gene expression by light and the circadian clock.
Circadian rhythms in a wide variety of cellular and metabolic processes are well documented in many organisms. An important step in understanding the molecular basis of the circadian clock is the characterization of clock-controlled genes. mRNA...
Dartmouth Dissertations

Reward and self-regulation in online digital environments.
Reward (Psychology). ; Self-control. ; Internet addiction -- Physiological aspects. ; Behavior Addictive -- pathophysiology.
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Dartmouth Dissertations

Behavioral and neural investigations of behaviorally relevant features of auditory stimuli.
Auditory pathways -- Physiology. ; Auditory perception -- Physiological aspects. ; Directional hearing -- Physiological aspects. ; Speech perception -- Physiological aspects. ; Prefrontal cortex -- Physiology. ; Parietal lobes -- Physiology. ;...
Studies of the structure and function of the human and non-human primate auditory system have led to the hypothesis that it is composed of dorsal and ventral processing streams that are respectively dedicated to spatial and non-spatial processing....
Dartmouth Dissertations

Memory and the resting brain.
Memory -- Physiological aspects. Hippocampus (Brain) -- Physiology. Perceptual-motor processes. Brain -- Variation.
Dartmouth Dissertations

Perceived annoyance as a function of number of noise events and maximum noise level.
Noise -- Psychological aspects. ; Sound -- Psychological aspects. ; Auditory perception.
The problem of perceived annoyance as a function of number of noise events and maximum noise level was investigated in a series of seven laboratory experiments. Four models were tested: the Equal Energy Model, the Scandinavian Model, the Variance...
Dartmouth Dissertations

Molecular analysis of heterochronic gene lin-14 and developmental cell cycle control in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Cellular control mechanisms. ; Cell cycle.
During postembryonic development of C. elegans the heterochronic gene lin-14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 transcripts are predicted to encode isoforms of a novel nuclear protein that...
Dartmouth Dissertations

Use of ionomics to identify genes that play a role in Arabidopsis metal homeostasis.
Arabidopsis -- Genetics. ; Cobalt -- Metabolism -- Genetic aspects. ; Iron -- Metabolism -- Genetic aspects. ; Nickel -- Metabolism -- Genetic aspects. ; Homeostasis.
Understanding trace element homeostasis in plants has a direct impact on global health. Much of the developing world suffers from nutrient deficiencies, and subsists on a plant based diet often lacking bioavailable nutrients like iron and zinc. At...
Dartmouth Dissertations

Iron uptake in Arabidopsis thaliana.
Arabidopsis thaliana. ; Iron -- Metabolism. ; Growth (Plants). ; Plants -- Effect of iron on.
Dartmouth Dissertations

FGF2 in endothelial cell migration, intracellular signalling and receptor endocytosis.
Fibroblast growth factors. Rho GTPases. Cell receptors. Integrins -- Physiological effect. Endocytosis. Vascular endothelium. Cellular signal transduction.
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
Dartmouth Dissertations

Regulation of human monocyte CD163 during the innate immune response to infection.
CD antigens. Immune response -- Regulation. Hemoglobin.
CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
Dartmouth Dissertations

The Matrix Metalloproteinase-1/protease activated receptor-1 signaling axis in melanoma progression.
Collagenases -- Pathophysiology. Metalloproteinases -- Pathophysiology. Melanoma -- Molecular aspects. Matrix Metalloproteinase 1.
The inappropriate expression of Matrix Metalloproteinases (MMPs) contributes to the pathology of many cancers. Among these, melanoma is a particularly insidious disease in that it is almost completely resistant to every known the therapy, and the...
Dartmouth Dissertations

Regulation of peripheral tolerance by mast cells.
Mast cells -- Immunology. Mast cells -- Physiology. Dendritic cells. Immunological tolerance -- Molecular aspects. Medical Term Cell Degranulation.
Mast cells (MC) have until recently been regarded as pro-inflammatory, however this view changed with the observation that the absence of MC impairs the development of transplant tolerance to allografts. However, little is known about whether MC...
Dartmouth Dissertations

The impact of sodium channel isoform expression on cerebellar Purkinje cell development.
Purkinje cells. Sodium channels -- Genetic aspects. Excitation (Physiology). Neurons -- Physiology. Cerebellum -- Physiology. Genetic regulation.
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Dartmouth Dissertations

Molecular analysis of novel ER membrane proteins important for homeostasis in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Biological transport -- Regulation. Proteins -- Biodegradation. Proteins -- Synthesis -- Regulation. Endoplasmic reticulum. Cellular control mechanisms. Saccharomyces cerevisiae -- Molecular aspects.
Endoplasmic reticulum (ER) homeostasis requires the coordination of anabolic and catabolic activities. A primary function of the ER is the biosynthesis and export of secretory proteins and lipids. Anterograde transport of only properly folded and...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Alterations in the production of bacteriochlorophyll a and okenone in purple sulfur bacteria : implications for the interpretaion of their biomarkers / by Derek A. Smith.
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Dartmouth Dissertations

Crevasse detection in ice sheets using ground penetrating radar and machine learning / by Rebecca M. Williams.
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Dartmouth Dissertations

Security-policy analysis with eXtended unix tools / by Gabriel A. Weaver.
During our fieldwork with real-world organizations---including those in Public Key Infrastructure (PKI), network configuration management, and the electrical power grid---we repeatedly noticed that security policies and related security artifacts...
Dartmouth Dissertations

Chemico-physical and pharmacologic factors that influence delivery of IONPs to tumors in rodent breast cancer models / by Jennifer Tate.
Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Automatic spectral classification.
Stars -- Spectra -- Classification. Stars -- Open clusters.
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations