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- 14-3-3 sigma modulates pancreatic cancer cell survival and invasiveness.
- Pancreas -- Cancer -- Pathophysiology. Pancreatic duct -- Pathophysiology. Proteins -- Pathophysiology. 14-3-3 Proteins -- physiology. Pancreatic Neoplasms -- pathology.
- 14-3-3 is down-regulated in certain human cancers, but its expression is increased in pancreatic ductal adenocarcinoma (PDAC). The purpose of the present study was to investigate the potential role of 14-3-3σ in PDAC. The levels of 14-3-3...
- Dartmouth Dissertations
- A computational dissection in the evolution of cell growth.
- Genetic regulation. Cells -- Growth -- Regulation. Ribosomes. DNA -- Synthesis. Evolutionary genetics.
- Gene regulation is a principle tool that all organisms utilize to control development, growth, and responses to environmental conditions. Understanding how organisms orchestrate the spatiotemporal regulation of gene expression remains a fundamental...
- Dartmouth Dissertations
- $Stark-geometry photorefractive multiple quantum well spatial light modulators.$
- Stark-geometry photorefractive multiple quantum well spatial light modulators.
- Light modulators -- Mathematical models. ; Quantum wells. ; Photorefractive materials. ; Optoelectronic devices -- Mathematical models.
- Stark-geometry photorefractive multiple quantum well (PR-MQW) spatial light modulators (SLMs) show promise for several optoelectronic applications such as high-speed image correlation and real-time 3-D holographic imaging. Their performance is...
- Dartmouth Dissertations
- The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
- Partially ordered sets. ; Forcing (Model theory). ; Set theory.
- Dartmouth Dissertations
- Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
- Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
- Dartmouth Dissertations
- Measuring quality of life in economic evaluations of treatment for severe mental illness.
- Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
- Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
- Dartmouth Dissertations
- Fault modeling and design of dynamic logic.
- Logic programming. ; Electronic digital computers -- Circuits -- Testing -- Mathematical models. ; Fault-tolerant computing.
- Today''s fastest microprocessors, logic chips, and even memory chips employ dynamic logic as the key part to achieving advanced performance. Dynamic logic only retains the correct data state briefly and is far less robust than previous technologies...
- Dartmouth Dissertations
- The function of perceived gaze direction in emotion and person perception.
- Gaze -- Psychological aspects. ; Facial expression. ; Body language.
- The primary goal of the current research was to examine the effect of perceived gaze direction on the perception and processing of facially communicated emotion. There is good reason to believe that gaze direction and facial displays of emotion...
- Dartmouth Dissertations
- Aging minds and twisting attitudes: effects of age-related decline in executive function on older adults' attitudes toward stigmatized individuals.
- Stigma (Social psychology). Aging -- Psychological aspects. Cognition -- Age factors. Older people -- Attitudes.
- Extensive research on aging has demonstrated that normal aging debilitates executive function, a system that is critical for regulating stereotypes. However, there is a paucity of research on whether age-related declines to executive function...
- Dartmouth Dissertations
- Biproducts in the rational cohomology of biformal spaces.
- Homotopy theory.
- Dartmouth Dissertations
- Cytoskeletal reorganization in B lymphocyte activation.
- Lymphocyte transformation.
- Dartmouth Dissertations
- Structure, petrology, and U-Th-Pb geochronology in the Milford (15') quadrangle, New Hampshire.
- Petrology -- New Hampshire -- Milford. ; Geological time.
- Dartmouth Dissertations
- Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
- Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
- The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
- Dartmouth Dissertations
- Structural, stratigraphic, and thermo-chronological evolution of Trinidad.
- Geochronometry -- Trinidad and Tobago -- Trinidad. ; Geology Structural -- Trinidad and Tobago -- Trinidad. ; Geology.
- Dartmouth Dissertations
- Clay mineralogy and geochemistry of soils and sediments with perma frost in interior Alaska.
- Clay minerals -- Alaska. ; Soils -- Alaska. ; Frozen ground -- Alaska.
- Dartmouth Dissertations
- The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
- Glycoproteins. ; Monoclonal antibodies. ; Immune response.
- Dartmouth Dissertations
- Migmatite systematics and geology : Carter Dome-Wild River Region White Mountains New Hampshire.
- Migmatite -- New Hampshire. ; Geology -- New Hampshire.
- Dartmouth Dissertations
- Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
- Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
- Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
- Dartmouth Dissertations
- Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
- Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
- Dartmouth Dissertations
- Intuitive user-guided appearance editing.
- Image processing -- Digital techniques. ; Computer algorithms. ; Human-computer interaction.
- We present new appearance editing algorithms that allow artists to perform complex editing operations on spatially-varying appearance datasets such as images and measured materials, in an intuitive and efficient manner. The goal is to develop...
- Dartmouth Dissertations
- Analysis of reactor configurations for combined anaerobic-aerobic biotreatment of perchloroethylene.
- Anaerobic bacteria -- Analysis. ; Biodegradation -- Testing. ; Bacteria Aerobic -- Analysis. ; In situ bioremediation -- Methodology. ; Bioremediation -- Methodology. ; Tetrachloroethylene -- Analysis.
- Chlorinated ethenes are ubiquitous environmental pollutants of public concern due to their potential toxicity and carcinogenicity. Under appropriate conditions anaerobic bacteria mediate the dechlorination of perchloroethylene (a common dry...
- Dartmouth Dissertations
- High resolution infrared spectroscopy and photolysis of solutes in cryogenic solids.
- Infrared spectroscopy. ; Photodissociation. ; Argon. ; Nitrogen.
- Dartmouth Dissertations
- Early earth and solar system evolution: insights from strontium, barium, neodymium, and samarium isotopes.
- Chondrites (Meteorites). ; Mantle plumes. ; Samarium-neodymium dating. ; Strontium -- Isotopes. ; Barium -- Isotopes. ; Solar system. ; Earth -- Mantle.
- Dartmouth Dissertations
- Androgens and the display of sexual receptivity in female rats: mechanisms for the inhibition of estrogen-induced sexual receptivity.
- Androgens -- Physiological effect. ; Androgens -- Receptors. ; Rats -- Physiology. ; Sexual behavior in animals.
- The present dissertation examined the effects of naturally occurring and synthetic androgens on estrogen-induced sexual receptivity in rats and examined the role of the androgen receptor in mediating these effects. First, the effects of naturally...
- Dartmouth Dissertations
- Transformation-group C*-algebras with bounded trace.
- C*-algebras. ; Transformation groups.
- Dartmouth Dissertations
- Neo-architectonics computer-aided histological examination of the human visual cortex.
- Visual cortex -- Imaging. ; Visual cortex -- Histology. ; Image processing -- Digital techniques.
- Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
- Dartmouth Dissertations
- Imaging performance in advanced small pixel and low light image sensors / by Leo Anzagira
- The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
- Dartmouth Dissertations
- The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
- Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
- Dartmouth Dissertations
- Isotopic phase separation in dilute solid mixtures of Helium-4 in Helium-3.
- Helium -- Isotopes. ; Isotope separation.
- Dartmouth Dissertations
- Dependence of snow thermal and electrical conductiveness on microstructure.
- Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
- Dartmouth Dissertations
- Discovering MII1 regulated pathways in hematopoietic stem cells.
- Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
- Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
- Dartmouth Dissertations
- Development and application of a dual-excitation, digital imaging, fluorescence microscope to investigate parathyroid hormone-stimulated calcium transport in kidney distal tubule cells.
- Fluorescence microscopy. ; Calcium -- Physiological transport -- Measurement. ; Renal tubular transport -- Measurement.
- Dartmouth Dissertations
- Bacterial flagellar motility facilitates host phagocyte association, engulfment, and inflammatory responses / by Rustin Lovewell.
- The immune system cannot effectively clear the highly motile, opportunistic pathogen Pseudomonas aeruginosa in chronically infected patients. Phagocytosis is the primary means of bacterial clearance in P. aeruginosa infections, and thus the central...
- Dartmouth Dissertations
- Effect of uniaxial stress on F-center hyperfine interactions.
- Solids.
- Dartmouth Dissertations
- Spectral studies of the enzyme rhodanese.
- Enzymes.
- Dartmouth Dissertations
- Firefighting on geometric graphs.
- Graph theory. ; Infinite groups. ; Geometrical constructions. ; Geometry Plane.
- In the Firefighter Problem, a fire starts at a vertex of a graph, and in discrete time units, it spreads from burned vertices to their neighbors, unless they are protected by one of the f firefighters that are deployed every turn. Once burned or...
- Dartmouth Dissertations
- Methods for rapid EEG-based mapping of human brain functions.
- Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
- Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
- Dartmouth Dissertations
- Metamorphism in east central Vermont.
- Metamorphism (Geology) -- Vermont. ; Nappes (Geology) -- Vermont.
- Dartmouth Dissertations
- Higher order Whitehead products.
- Homotopy theory. ; Topology.
- Dartmouth Dissertations
- Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- Baseball Teams 1900-1910
- Baseball Teams 1900-1910
- Notes on back indicate than when names were written on photo "Kid" Knight '89 and "Chris" Anderson '89 were both deceased.
- Dartmouth College Photographic Files
- The dorsal tegmental nucleus of Gudden and angular velocity integration in the head direction system.
- Space perception. ; Motion perception (Vision). ; Vestibular apparatus.
- Head Direction (HD) cells are neurons located primarily in the limbic system that fire as a function of directional heading in the horizontal, or yaw, plane in the freely moving animal. Our hypothesis is that the HD signal is the result of two...
- Dartmouth Dissertations
- Hamiltonians, invariants and magnetic field-line topology.
- Magnetic fields -- Mathematical models. ; Hamiltonian systems. ; Invariants.
- Dartmouth Dissertations
- Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
- Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
- The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
- Dartmouth Dissertations
- Quantitative analysis of EEG for the detection and localization of seizures in patients with medically refractory epilepsy.
- Electroencephalography -- Data processing. ; Epilepsy -- Diagnosis. ; Signal processing -- Mathematics. ; Time-series analysis. ; Wavelets (Mathematics).
- Visual interpretation of the EEG associated with an epileptic seizure (ictal EEG) can be cumbersome and sometimes misleading, due to rapid seizure spread, limited spatial resolution and the fact that signals of interest are often obscured by...
- Dartmouth Dissertations
- Providing evidence and measurement tools to support health care reform in communities.
- Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
- Dartmouth Dissertations
- Isolation of interleukin-2-induced immediate-early genes.
- Interleukin-2.
- Dartmouth Dissertations
- Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
- Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
- Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
- Dartmouth Dissertations
- Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
- Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
- Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
- Dartmouth Dissertations
- Homing, density and population dynamics in the adult newt, notopthalmus viridescens rafinesque.
- Newts.
- Dartmouth Dissertations

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