Outcome assessment (Medical care). ; Aortic valve -- Surgery -- Complications. ; Aortic valve -- Surgery -- New England. ; Cardiovascular instruments Implanted.
Aortic valve disease is a frequent and serious disorder. Although aortic valve replacement (AVR) is arguably the only effective treatment, important issues remain unresolved in the care of patients with this disease. Recent studies have focused...
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
Understanding mercury (Hg) and lead (Pb) accumulation and retention in forest soils is needed to reduce their negative impacts on human and wildlife health. In addition, mercury and lead can be used to characterize the role of soil in terrestrial...
Rufous-crowned sparrow -- Effect of habitat modification on. ; Rufous-crowned sparrow -- California Southern. ; Fragmented landscapes -- California.
The Rufous-crowned Sparrow (Aimophila ruficeps ; RCSP) is a non-migratory, ground-nesting songbird that resides in southern California coastal sage scrub, which has been highly fragmented by urban development. RCSP's spatial pattern of abundance...
Cancer Control Program (National Cancer Institute) -- Evaluation. Cancer -- Treatment -- United States -- Evaluation. Cancer -- Patients -- Care -- Evaluation.
Background. Disparities in access to cancer care and cancer-related outcomes have been demonstrated in the U.S. Patterns of access to National Cancer Institute-designated Cancer Centers (NCI-CCs), the most specialized cancer care settings, have not...
The Dartmouth Stellar Evolution Program, a state of the art stellar evolution code, has been modified and expanded to increase its versatility. The modifications include: the ability to self-consistently model stars with arbitrary chemical...
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
How is concrete conceptual information represented in the brain? Little is known about the neural organization for details of concrete objects when presented as words. The goal of the first two studies was to investigate this. In the third study,...
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
This thesis explores practical and theoretical aspects of several privacy-providing technologies, including tools for anonymous web-browsing, verifiable electronic voting schemes, and private information retrieval from databases. State-of-art...
Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
APETALA3 ( AP3 ) and PISTILLATA ( PI ) are floral organ identity genes that are necessary and sufficient for petal and stamen development. Surprisingly little is known about molecular mechanisms by which AP3 and PI proteins direct floral organ...
The ubiquitous complexity of common diseases is one of the biggest challenges facing the field of personalized treatments and precision medicine. This complexity can be attributed to various sources such as the genetic make-up of an individual,...
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
The image of a child standing at the side of a creek and skipping stones across it exemplifies how we tend to mentally separate aquatic habitats from dry land. But there is a constant exchange of materials from land to streams, and vice-versa....
The rat limbic system contains head direction (HD) cells that fire according to heading in the horizontal plane. These HD cells are thought to provide animals with an internal compass to guide navigation. Previous work has found that HD cell tuning...
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Cyclic diguanylate (c-di-GMP) is a primarily bacterial and nearly universal second messenger used to stimulate a variety of responses from the cell by binding effector proteins. It is created by enzymes called diguanylate cyclases (DGCs) and broken...
Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
This dissertation examines the behavioral and physiological adaptations employed by modern humans to subsist in tropical rainforests. I employ various theoretical and methodological approaches to test hypotheses using empirical data from African...
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors (IL-2R) on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is...
Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...