Dartmouth Digital Library Program

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Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Regulation of B lymphocyte proliferation and differentiation through CD40.
B cells. CD antigens. Immune response -- Regulation.
Dartmouth Dissertations

CD8+ T cell responses to acute and chronic viral infections governed by costimulatory signals and CD4 help.
T cells. T cells -- Receptors. CD antigens. CD4 antigen. Immunologic memory. Herpesvirus diseases -- Immunological aspects. Vaccinia. CD8-Positive T-Lymphocytes -- immunology. CD4-Positive T-Lymphocytes -- immunology. Herpesviridae Infections --...
The phenomenon of immunological memory has been known for thousands of years. This knowledge has been applied to vaccination, which has resulted in a dramatic reduction in the number of deaths due to infectious diseases. Immunological memory is...
Dartmouth Dissertations

Development and application of a genetically-structured simulation for bacteriophage T7.
Viral genetics -- Mathematical models. ; Bacteriophages -- Growth -- Computer simulation. ; Recombinant viruses. ; Bacteriophage T7.
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Insights into the assembly and organization of higher-order septin structures.
Septins. ; Proteins -- Structure. ; Fluorescence spectroscopy. ; Molecular biology -- Instruments. ; GTP-Binding Proteins.
Dartmouth Dissertations

Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae.
Iron-sulfur proteins.
Dartmouth Dissertations

Reaggregation of sea urchin embryonic cells.
Sea urchins -- Embryos. ; Embryology Experimental. ; Cell aggregation.
Dartmouth Dissertations

Modulating innate and adaptive immunity in the Toxoplasma gondii-induced model of inflammatory bowel disease.
Toxoplasma gondii -- Immunology. Inflammatory bowel diseases -- Immunological aspects. C-reactive protein. T cells. Immune response -- Regulation. Protein precursors -- Immunology.
Inbred C57BL/6 mice develop an acute necrotizing ileitis following oral infection with Toxoplasma gondii that is associated with massive inflammatory infiltrates and morphologic tissue changes consistent with human Crohn's disease. In the course of...
Dartmouth Dissertations

ACAT1 in macrophage as a potential target for atherosclerosis and for diet induced obesity / by Li-Hao (Paul) Huang.
Acyl-CoA: cholesterol acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. There are two isoenzymes, ACAT1 and ACAT2. Here I performed biochemical analyses of individual amino acids within c-terminal loop of ACAT1 and showed...
Dartmouth Dissertations

Identification of the glucose transport system in purified rat adipose cell plasma membranes
Glucose -- Metabolism. Insulin -- Physiological effect.
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

Studies in the role of ubiquinone in the microbicidal events of neutrophils
Ubiquinones. Neutrophils.
The oxygen-dependent microbicidal events of neutrophils have been studied with reference to the triggering of the respiratory burst and with particular emphasis on the role of quinone. Ubiquinone as well as a previously described cytochrome b were...
Dartmouth Dissertations

Optical constants of noble and transition metals.
Metals -- Optical properties.
Dartmouth Dissertations

The role of mitochondria in chromium carcinogenesis.
Chromium. Carcinogens. ; Mitochondria.
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Circadian and non-circadian oscillators in Neurospora crassa.
Circadian rhythms. Neurospora crassa -- Genetics. Genetic transcription -- Regulation. Choline. Temperature. Circadian Rhythm -- genetics. Choline Deficiency -- genetics.
The circadian clock of the filamentous fungus, Neurospora crassa, consists of a frequency-white-collar ( frq-wc ) based and transcription-translation-derived oscillator. Negative feedback regulation is essential for the oscillatory process, in...
Dartmouth Dissertations

Synthetic approaches to pyridocarbazoles via new indole and pyridine lithiaton methodology.
Antineoplastic agents. ; Pyridocarbazoles.
Dartmouth Dissertations

Novel approaches to targeting innate immunity for cancer immunotherapy / by Patrick H. Lizotte
Many kinds of cancer, and almost universally metastatic cancer, are refractory to treatment by conventional methods: surgery, radiation, and non-specific cytotoxic chemotherapy. The dawn of the age of personalized medicine presaged 15 years ago...
Dartmouth Dissertations

Identification of signaling pathways coordinating cell growth and division in fission yeast / by Lin Deng
Cell growth and division are coordinated to keep homeostasis of cell size. The components of the core machinery are conserved in a wide range of cell types. Fission yeast (S. pombe) has been an important model organism to study cell size control...
Dartmouth Dissertations

A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations

In vitro reconstitution of exocytosis from sea urchin egg plasma membrane and isolated secretory vesicles.
Sea urchins -- Cytology.
Dartmouth Dissertations

Rabbit genomic clones for synovial fibroblast collagenase: tools for understanding connective tissue disease.
Collagenases. ; Fibroblasts. ; Connective tissues -- Diseases -- Genetic aspects. ; Clone cells. ; Rabbits.
Dartmouth Dissertations

Bcl-2 family proteins and the regulation of apoptosis.
Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
Dartmouth Dissertations

Role of cytochrome P4503A in acetaminophen toxicity.
Acetaminophen -- Toxicology. ; Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Rats -- Physiology.
CYP3A has the highest affinity for oxidation of Acetaminophen (APAP) with a Km close to the concentration observed in human serum after administration of therapeutic doses of APAP. CYP3A may be induced by numerous drugs as well as alcohols. We...
Dartmouth Dissertations

TRAF dependence of CD40 signaling in B cells.
B cells. ; CD antigens. ; Lymphocytes -- Receptors. ; Signal Transduction. ; Antigens CD40 -- immunology. ; B-Lymphocytes -- immunology.
Dartmouth Dissertations

Molecular analysis of mannose-sensitive hemagglutinin formation and toxin secretion by Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Hemagglutinin -- Analysis. ; Peptidase -- Pathophysiology.
The mannose-sensitive hemagglutinin (MSHA) of Vibrio cholerae is a member of the family of type 4 pili. Type 4 pili expressed on the surface of a number of Gram-negative bacteria are often required for host colonization. MSHA is specifically...
Dartmouth Dissertations

The role of CD154/CD40 interactions in the development and persistence of CD4+ T cell-mediated immunity.
CD antigens. ; T cells -- Receptors. ; Tumors -- Immunological aspects. ; Mice -- Immunology. ; CD4-Positive T-Lymphocytes. ; Antigens CD40.
The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
Dartmouth Dissertations

Von Hippel Lindau (VHL) tumor suppressor regulation of MT1-MMP in renal cell carcinoma.
Antioncogenes. Metalloproteinases. Genetic regulation. Kidneys -- Cancer.
Dartmouth Dissertations

The effect of estradiol-17ß and insulin on protein synthesis in primary monocultures of amphibian hepatocytes.
Proteins -- Synthesis. ; Insulin. ; Hormones. ; Amphibians.
Dartmouth Dissertations

The role of the chromokinesin Kid in chromosome alignment and spindle assembly in mammalian mitosis.
Chromosome replication. Mitosis. Muscle proteins. Spindle (Cell division).
Dartmouth Dissertations

Regulation of the floral organ identity gene APETALA3 in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics. ; Genetic regulation.
APETALA3 (AP3) is a MADS box gene required for normal development of the petals and stamens in the Arabidopsis flower. AP3 transcriptional regulation occurs in two stages; an initial establishment phase, which is mediated by LEAFY (LFY) and UNUSUAL...
Dartmouth Dissertations

Immunological and molecular characterization of a 62 kDa mitotic apparatus-associated protein important for mitotic progression.
Mitosis. ; Nucleoproteins. ; Sea urchins -- Embryos. ; Molecular biology.
A 62 kDa (p62) mitotic apparatus-associated protein has been shown to be important for the proper progression of mitosis in sea urchin embryos. The thesis project described here focuses on an immunological and a molecular characterization of p62....
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Splicing thermotolerance in Drosophila melanogaster.
Heat -- Physiological effect. ; Cells -- Effect of temperature on. ; RNA splicing. ; Drosophila melanogaster.
Dartmouth Dissertations

Tumor necrosis factor contributes to early diabetic nephropathy.
Tumor necrosis factor. ; Diabetic nephropathies -- Pathogenesis. ; Renal tubular transport Disorders of.
Early renal changes during diabetes include sodium (Na) retention and renal hypertrophy. Tumor Necrosis Factor (TNF) is elevated during diabetes and is implicated in the pathogenesis of diabetic nephropathy. We tested the hypothesis that TNF...
Dartmouth Dissertations

Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent regularion of cholesterol biosynthesis and LDL receptor expression.
Molecular cloning. ; Genetic regulation. ; Somatic cells. ; Sterols. ; Cholesterol -- Metabolism.
Dartmouth Dissertations

TGF-beta1 regulation of Th1 development and autoimmunity.
Transforming growth factors-beta. ; Th1 cells. ; Transcription factors. ; Autoimmunity. ; Cytokines. ; Immune response -- Regulation. ; T cells. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Cloning and expression of HVACM, a cullin protein, from small cell lung cancer.
Vasopressin -- Receptors. ; Small cell lung cancer. ; Genetic regulation. ; Molecular cloning. ; Immunohistochemistry.
Dartmouth Dissertations

Synthetic studies on viridin class of furanosteroids.
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Dartmouth Dissertations

The role of retinoic acid on CD4+ T cell biology.
T cells.; Tretinoin -- Physiological effect. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Cellular and molecular effects of chromium on the activity and expression of fibrinolytic proteins in epithelial cells.
Chromium -- Therapeutic use. ; Fibrinolysis. ; Epithelial cells. ; Pulmonary fibrosis.
Transition metals play critical roles in biological systems as essential components of metalloproteins and metalloenzymes, as diagnostic probes and pharmaceuticals, and in some instances, as sources of toxicity. Cellular concentrations vary...
Dartmouth Dissertations

Isolation and characterization of Chinese hamster ovary cell lines possessing abnormal LDL-derived cholesterol trafficking.
Cholesterol. ; Mutation (Biology). ; Low density lipoproteins. ; Cell lines.
Dartmouth Dissertations

Studies on the regulation of synthesis and activity of NADP- and NAD- specific glutamate dehydrogenases from Neurospora crassa.
Enzymes. ; Metabolism. ; Ascomycetes.
Dartmouth Dissertations

Mechanisms for the enhancement of radiation-induced cell killing by carboplatin.
Antineoplastic agents. ; Radiation chemistry. ; Cancer -- Treatment. ; Cell death.
Dartmouth Dissertations

Structure based drug discovery of potent and specific antimicrobial agents for anthrax.
Bacillus cereus. Anti-infective agents -- Design. Enzyme inhibitors -- Therapeutic use. Enzyme inhibitors -- Structure-activity relationships. Folic acid -- Antagonists. Anthrax -- Treatment. Tetrahydrofolate Dehydrogenase.
Infections by pathogenenic microbes are an increasing problem due to a lack of universal vaccines and growing resistance to current antibiotics. The constant battle for researchers in the fight against pathogens is to design new and improved drugs...
Dartmouth Dissertations

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