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All fields: insulin

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- The effect of estradiol-17ß and insulin on protein synthesis in primary monocultures of amphibian hepatocytes.
- Proteins -- Synthesis. ; Insulin. ; Hormones. ; Amphibians.
- Dartmouth Dissertations
- Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
- Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
- Dartmouth Dissertations
- Vibrio cholerae lipopolysaccharide peptide mimicry.
- Endotoxins -- Immunology. Vibrio cholerae -- Immunology. Mimicry (Chemistry). Antigenic determinants. Peptides -- Immunology. Molecular mimicry -- immunology. Epitopes -- immunology.
- The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...
- Dartmouth Dissertations
- Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
- Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
- Dartmouth Dissertations
- The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
- Glycoproteins. ; Monoclonal antibodies. ; Immune response.
- Dartmouth Dissertations
- Synthesis, structure, and reactivity of cationic palladium secondary phosphine complexes.
- Phosphine. ; Organophosphorus compounds -- Synthesis. ; Transition metal compounds. ; Complex compounds.
- Dartmouth Dissertations
- The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
- Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
- Dartmouth Dissertations
- Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
- Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
- Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
- Dartmouth Dissertations
- Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
- All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
- Dartmouth Dissertations
- The regulation of AMP-activated protein kinase (AMPK) in an insulinoma cell line, adipocytes and muscle.
- Protein kinases. ; Adenylic acid. ; Islands of Langerhans -- Tumors. ; Fat cells. ; Muscle cells. ; Adenoviruses.
- Dartmouth Dissertations
- Early events in insulin signaling: tyrosine phosphorylation and phosphatidylinositol 3-kinase activation.
- Insulin -- Receptors. ; Tyrosine. ; Phosphorylation. ; Phosphoinositides.
- Dartmouth Dissertations
- Increases in specific forms of hepatic cytochrome P450s by ethanol and isopentanol: mechanism of the response.
- Hepatotoxicology. ; Alcohol -- Toxicology. ; Cytochromes.
- Dartmouth Dissertations
- A study of neutral amino acid and drug transport.
- Placenta. ; Maternal-fetal exchange.
- Dartmouth Dissertations
- Properties of adenylate kinase from Paracoccus denitrificans and comparison with the enzyme from cytosol and mitochondria.
- Adenylate kinase. ; Paracoccus denitrificans. ; Enzymes.
- Dartmouth Dissertations
- Dexamethasone causes translocation of glucose transporters from the plasma membrane to an internal site.
- Glucocorticoids. ; Glucose -- Physiological transport. ; Glucose -- Metabolism.
- Dartmouth Dissertations
- Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
- Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
- Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
- Dartmouth Dissertations
- Studies on the mode of action of glucocorticoids in islated rat tymus cells: investigations into the latency and site of corticol inhibition of glucose uptake and glucose 6-phosphate accumulation.
- Glucocorticoids.
- Dartmouth Dissertations
- Medicine: July 1996; Dartmouth Hitchcock Medical C...
- Dartmouth College Photographic Records
- Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
- Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
- Dartmouth Dissertations
- Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
- In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
- Dartmouth Dissertations
- Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
- Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- Novel techniques for the investigation of GPCR structure and function / by Joshua A. Weiner.
- G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
- Dartmouth Dissertations
- Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
- The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
- Dartmouth Dissertations
- Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
- Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
- To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
- Dartmouth Dissertations
- Characterization of the monosaccharide transport system of the thioglycollate-elicited mouse peritoneal macrophage and in vitro actions of glucocorticoids on macrophage growth, glucose metabolism, and monosaccharide transport
- Glucose -- Metabolism. Macrophages. Glucocorticoids. Mice
- Dartmouth Dissertations
- Kinetic characterization of metabolism and antibody production of a hybridoma cell line in high density homogeneous perfusion culture.
- Hybridomas -- Metabolism. Hybridomas -- Growth. Cultures (Biology).
- Dartmouth Dissertations
- Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
- Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
- Dartmouth Dissertations
- Muscle-specific and activity-dependent transcriptional regulation of nicotinic acetylcholine receptor subunit gene.
- Acetylcholine -- Receptors -- Genetic aspects. ; Muscles -- Innervation. ; Neuroplasticity.
- Dartmouth Dissertations
- Glutaredoxins and CPF: the backbone dynamics, resonance assignments, secondary structure, and isotopic labeling of DNA and proteins.
- Genetic transcription -- Regulation. ; Glutaredoxin. ; Vaccinia -- Genetics. ; Escherichia coli -- Genetics. ; DNA-protein interactions.
- Dartmouth Dissertations
- Identification of crucial residues involved in the catalysis of acyl-coenzyme A:cholesterol acyltransferase.
- Acyltransferases. ; Cholesterol -- Metabolism. ; Catalysis. ; Acyl Coenzyme A. ; Cholesterol Acyltransferase.
- Acyl-coenzyme A: cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and in early stages of atherogenesis. ACAT has been investigated as a pharmaceutical target, yet its active site(s) remain largely...
- Dartmouth Dissertations
- The biochemical basis of Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- An examination of Raf-1 expression and kinase activity throughout the T lymphocyte cell cycle.
- Proto-oncogenes. ; T cells. ; Phosphotransferases.
- Dartmouth Dissertations
- The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
- Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
- Dartmouth Dissertations
- Proteins of rat liver lysomal membranes: characterization, biosynthesis and comparison with plasma membranes.
- Lysosomes. ; Cell membranes.
- Dartmouth Dissertations
- The molecular basis of chromium carcinogenesis.
- Chromium. ; Carcinogens.
- Dartmouth Dissertations
- Studies on the cell surface complex of the sea urchin: a model for in vitro exocytosis.
- Sea urchins -- Cytology.
- Dartmouth Dissertations
- The regulation of gene expression by BRCA1 splice-variants in human mammary epithelial cells.
- Antioncogenes. ; Genetic transcription -- Regulation. ; Mutation (Biology). ; Epithelial cells. ; Mammary glands -- Tumors. ; Proto-Oncogene Proteins. ; Breast Neoplasms -- genetics. ; BRCA1 Protein. ; Genes BRCA1 -- physiology.
- Dartmouth Dissertations
- Molecular cloning and functional characterization of BRCA1 splice variants in human mammary cells.
- Antioncogenes. ; Breast -- Cancer -- Genetic aspects.
- BRCA1 has been identified as a tumor suppressor gene that is mutated in many cases of inherited breast and ovarian cancer. Recent data suggest that multiple splice forms of BRCA1 exist, but the structure and function of these alternative...
- Dartmouth Dissertations
- The Spot 14 gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism.
- Nucleoproteins. ; Fatty acids -- Synthesis -- Genetic aspects. ; Breast -- Cancer -- Genetic aspects. ; Gene amplification. ; Oncogenes.
- Spot 14 (S14) is a ~17 KD nuclear protein that functions at the transcriptional level to regulate de novo synthesis of fatty acids in liver, brown and white adipose, and. lactating mammary tissues. Localization of the S14 gene to chromosome 11q13.5...
- Dartmouth Dissertations
- Requirements for the signaling of lysosomal secretion: two studies.
- Lysosomes. ; Secretion.
- Dartmouth Dissertations
- Identification of two small peptide products of translocation independent signal peptidase cleavage on bovine preprolaction.
- Peptides.
- Dartmouth Dissertations
- Breast cancer cells exploit normal stromal cells in the tumor microenvironment.
- Breast -- Cancer. Bone metastasis. Metalloproteinases -- Pathophysiology. Collagenases -- Pathophysiology. Chemokines -- Receptors. Fibroblasts.
- Breast cancer mortality results from frequent metastasis to specific vital organs (organotropism), a process facilitated by the collaborative effort put forth between neoplastic epithelial and stromal cells within the tumor microenvironment at the...
- Dartmouth Dissertations
- Does continuity matter?: measuring the quality of ambulatory care among chronically ill elders in the United States.
- Older people -- Medical care -- United States -- Evaluation. Chronically ill -- Medical care -- United States -- Evaluation. Ambulatory medical care -- United States -- Evaluation.
- Objective . To examine how continuity is related to quality measures for chronically ill elderly patients; to the specialty and caseload of the physicians they predominantly visit; and to the regional context of where their ambulatory care is...
- Dartmouth Dissertations
- Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
- Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
- Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
- Dartmouth Dissertations
- Identification of the glucose transport system in purified rat adipose cell plasma membranes
- Glucose -- Metabolism. Insulin -- Physiological effect.
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
- Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
- Dartmouth Dissertations
- Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
- Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
- Dartmouth Dissertations
- Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
- Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
- Dartmouth Dissertations

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