Dartmouth Digital Library Program

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CFTR trafficking and polarization in epithelial cells.
Epithelial cells. ; Cellular control mechanisms. ; Membrane proteins -- Physiological transport. ; Cystic fibrosis -- Genetic aspects.
The topic of this thesis dissertation is the trafficking and polarization of the cystic fibrosis transmembrane conductance regulator (CFTR) in Madin-Darby canine kidney (MDCK) and human airway epithelial cells. The thesis is divided into two...
Dartmouth Dissertations

A study of irradiance scintillation effects of an optical wave propogating through a turbulent atmosphere.
Plasma (Ionized gases). ; Wave-motion, Theory of.
Dartmouth Dissertations

Nonstigmatized individuals' reactions to the acknowledgment and valuation of a stigma by overweight individuals and physically disabled individuals.
Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
Dartmouth Dissertations

Optimization algorithms for site-directed protein recombination experiment planning.
Proteins -- Structure -- Mathematical models. Recombinant proteins -- Mathematical models. Mathematical optimization -- Data processing. Dynamic programming. Protein engineering.
Site-directed protein recombination produces improved and novel protein variants by recombining sequence fragments from parent proteins. The resulting hybrids accumulate multiple mutations that have been evolutionarily accepted together. Subsequent...
Dartmouth Dissertations

Investigation of the influence of lipids in ER to Golgi transport.
Membrane proteins -- Physiological transport. Coated vesicles -- Physiology. Phospholipids -- Physiological effect. Inositol phosphates -- Physiological effect. Carrier proteins -- Molecular aspects. Golgi apparatus. Endoplasmic...
The secretory pathway in eukaryotic cells is responsible for the exocytic and endocytic pathways, as well as for the delivery of proteins and lipids from their sites of synthesis to the cell surface and the different compartments of the...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
Dartmouth Dissertations

Assortativity and the robustness of gene regulatory networks / by Dov A. Pechenick.
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
Dartmouth Dissertations

Solute transport in snowpack and isotopic variations of a snowpack and its melt.
Snow -- Composition. Snow -- Mathematical models. Runoff. Hydrogen -- Isotopes. Oxygen -- Isotopes. Radioactive tracers.
Snowmelt from seasonal snow covers can be significant in many environments of northern and alpine areas. Water flow and chemical transport resulting from snowmelt have been studied for an understanding of contributions to watersheds or catchments....
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Damping and decoherence of a nanomechanical resonator due to two-level systems
Nanoelectromechanical systems -- Mathematical models. ; Resonators -- Mathematical models. ; Damping (Mechanics) -- Mathematical models. ; Multilevel models (Statistics) ; Materials at low temperatures.
Dartmouth Dissertations

Understanding the role of Toxoplasma gondii secreted rhoptry (ROP) and dense granule (GRA) effector proteins in host-parasite biology using reverse genetics / by Leah M. Rommereim
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
Dartmouth Dissertations

Characterization of cancer risk and response to immunotherapy through pathway-based genomic analyses / by David C. Qian
For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
Dartmouth Dissertations

Characterization of two Saccharamyces cerevisiae genes involved in mRNA export.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics. ; Proteins -- Synthesis -- Genetic aspects.
I report the further characterization of an essential S. cerevisiae nucleoporin, RAT7/NUP159, shown previously to be involved in mRNA export. The Rat7p/Nup159p can be divided into three domains: an N-terminal domain, a central repeat domain, and a...
Dartmouth Dissertations

On the scattering of beam electrons in a beam-plasma interaction.
Plasma diffusion. ; Electron beams. ; Scattering (Physics).
Dartmouth Dissertations

A social psychological perspective on the structure of personality: impression formation and the five factor model.
Personality. ; Social perception. ; Social interaction.
Dartmouth Dissertations

Biochemical and genetic characterization of subunit six from the Saccharomyces cerevisiae cytochrome bc[subscript 1] complex.
Cytochrome c. ; Peptides. ; Saccharomyces cerevisiae.
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
Dartmouth Dissertations

Enolase in vacuole fusion and enolase and Bor1p in trafficking of proteins to the vacuole in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Membrane fusion. Plant vacuoles. Biological transport -- Regulation. Saccharomyces cerevisiae -- Cytology.
Dartmouth Dissertations

The cognitive structure of the self-concept: implications for psychological well-being.
Self-perception. ; Cognitive psychology.
The present work examines the cognitive structure of the self-concept. Improving upon established measures of self-complexity (H -statistic), cognitive complexity of the self-concept is measured in terms of the number of self-aspects and the...
Dartmouth Dissertations

Use of ionomics to identify genes that play a role in Arabidopsis metal homeostasis.
Arabidopsis -- Genetics. ; Cobalt -- Metabolism -- Genetic aspects. ; Iron -- Metabolism -- Genetic aspects. ; Nickel -- Metabolism -- Genetic aspects. ; Homeostasis.
Understanding trace element homeostasis in plants has a direct impact on global health. Much of the developing world suffers from nutrient deficiencies, and subsists on a plant based diet often lacking bioavailable nutrients like iron and zinc. At...
Dartmouth Dissertations

Cyber-based behavioral modeling.
Human behavior -- Mathematical models. ; Web usage mining. ; Internet users.
Whom we e-mail, where we browse, what we purchase, and the things we search for on the World Wide Web all leave identifiable traces of who we are as individuals. In today's technology focused landscape, cyberspace represents the new environment in...
Dartmouth Dissertations

The identification of Gp39:CD40-A ligand receptor pair essential to humoral immunity: studies in the regulation of GP39 expression.
T cells -- Genetic aspects. ; B cells -- Genetic aspects. ; Ligand binding (Biochemistry). ; Lymphocyte transformation. ; Immune response -- Regulation. ; Immunogenetics.
Dartmouth Dissertations

The metric of visual space.
Space perception -- Measurement. ; Visual perception -- Measurement. ; Visual perception.
Dartmouth Dissertations

Analytical and numerical studies of coherent field configurations.
Phase transformations (Statistical physics) -- Mathematical models. ; Nonlinear systems -- Mathematical models. ; Bubbles -- Mathematical models.
Motivated by the goal of investigating the dynamics of the electroweak phase transition in the early Universe, a study of dynamical aspects of nonlinear field-theoretical systems is performed. Symmetric and asymmetric double-well potentials in the...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

A computational study of radio relics in galaxy cluster mergers / by Dane Patrick Owen.
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

A framework of computational opinions / by Fei Yu.
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Analysis of zooplankton dynamics: case studies of temporal succession controlled by the predator, Asplancha, and of diel cycles in Keratella.
Freshwater zooplankton. Predation (Biology).
Dartmouth Dissertations

Oxidative demethylation at C-4 of steroids.
Methylation. Hydroxylation. Steroids.
Dartmouth Dissertations

Impurity scattering on the Fermi surface.
Scattering (Physics) Fermi surfaces.
Dartmouth Dissertations

A prediction of the interaction of a normal shock with a separating, turbulent boundary layer.
Shock waves. Turbulent boundary layer.
Dartmouth Dissertations

Studies of equilibrium and dynamic properties of polymers.
Polymers. Chemical equilibrium.
Dartmouth Dissertations

Forest structure and atmospheric interactions : predictive models for subalpine balsam fir forest
Forest hydrology -- Mathematical models; Forest Meteorology -- Mathematical models; Balsam fir
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Spectroscopic analyses of type Ia supernovae / by Jerod Parrent.
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Dartmouth Dissertations

Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Dartmouth Dissertations

Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Characterization of an inducible model of a genetic prion disease in Drosophila melanogaster / by Archana Murali.
Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration. In humans, these disorders include Creutzfeldt-Jakob disease, kuru and...
Dartmouth Dissertations

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