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A thermodynamic investigation of metal ions binding to metal trafficking proteins, peptides and small molecules using isothermal titration calorimetry.
Metal ions. Binding sites (Biochemistry) -- Thermodynamics. Metalloenzymes. Cellular control mechanisms. Thermometric titration. Calorimetry.
The chemistry of biology is complex and there is a great deal that is not understood. A fundamental understanding of biochemical reactions is important to aid in the identification of undiscovered reactions and is critical to fully appreciate the...
Dartmouth Dissertations

Spectroscopic and magnetic studies of the nickel metalloenzyme urease.
Urease. Urease -- Magnetic properties. Urea. Hydrolysis.
Dartmouth Dissertations

Quantitative analysis of polycyclic aromatic hydrocarbons in airborne particulates: Semiquantitative determination of organic material in woodsmoke.
Hydrocarbons -- Analysis. Smoke -- Analysis.
Dartmouth Dissertations

Pre-clinical evaluation of the novel synthetic triterpenoid CDDO-imidazolide.
Triterpenoid saponins -- Physiological effect. ; Triterpenoid saponins -- Mechanism of action. ; Triterpenoid saponins -- Therapeutic use. ; Imidazoles. ; Cancer cells -- Growth -- Regulation.
1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-lm) is a novel synthetic triterpenoid superior to its parent compound, 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), both in vitro and in vivo. CDDO-Im is highly active in...
Dartmouth Dissertations

The chemistry of clay minerals associated with evaporites in New York and Utah.
Clay minerals -- Composition. Chlorites. Evaporites -- New York (State). Evaporites -- Utah.
Dartmouth Dissertations

Dielectric properties of moist soils at RF and microwave frequencies.
Soils -- Electric properties. Soil moisture -- Measurement. Dielectrics.
Dartmouth Dissertations

Simulating electron radiation belt dynamics.
Van Allen radiation belts -- Mathematical models. ; Magnetosphere -- Mathematical models. ; Magnetohydrodynamics -- Mathematical models.
The physics of geomagnetically-trapped radiation has been a topic of interest since the discovery of the Van Allen belts in 1958. As the energetic particles comprising these belts can pose a hazard to human activity in space, considerable effort...
Dartmouth Dissertations

Effects of anabolic androgenic steroids on GABAA receptor function and expression.
Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; GABA -- Receptors. ; GABA -- Physiological effect. ; Neurotransmitter receptors. ; Brain -- Physiology. ; Receptors GABA-A -- drug effects.
Dartmouth Dissertations

Interactions between tree species, soil, and nitrogen availability in fir-birch-spruce forests.
Plants -- Effect of nitrogen on. ; Nitrogen cycle. ; Forest ecology
Dartmouth Dissertations

Ring current oxygen interaction with micropulsations.
Ionospheric drift. ; Magnetospheric currents. ; Electric fields. ; Geomagnetic micropulsations. ; Active oxygen.
Dartmouth Dissertations

Molecular characterization of the DHP-sensitive, voltage-regulated calcium channel.
Calcium channels.
Dartmouth Dissertations

Partial, Purification and Properties Of A Soluble (Na++K+)-Dependent ATPase From Rabbit Kidney.
Adenosine triphosphatase.
Dartmouth Dissertations

A three-dimensional model for feedback unstable ULF waves at high latitudes / by Nan Jia.
Currently, the hypothesis that discrete auroral arcs are produced by fluxes of magnetospheric electrons accelerated along the ambient magnetic field into the ionosphere by linear/non-linear mechanisms associated with magnetic field-aligned currents...
Dartmouth Dissertations

A photoexcited three-component electron-hole plasma in type II GaAs/AlAs quantum wells.
Electron-hole droplets. Plasma (Ionized gases). Quantum wells.
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

Spectroscopic and magnetic studies of jack bean urease: pH and buffer effects on the Ni(II) coordination.
Urease. Urease -- Magnetic properties. Nickel. Hydrolysis. Canavalia ensiformis.
Dartmouth Dissertations

Collisional damping of waves in plasmas.
Plasma waves.
Dartmouth Dissertations

Sounding-rocket studies of Langmuir-wave microphysics in the auroral ionosphere / by Micah P. Dombrowski
Since their discovery in laboratory plasmas in the 1920s, Langmuir waves have been observed to be ubiquitous in plasma environments, particularly in space plasmas. From the greater solar wind to planetary foreshocks and the auroral ionosphere,...
Dartmouth Dissertations

Hybrid simulations of the interaction of energetic particles with MHD waves.
Magnetohydrodynamic waves -- Mathematical models. ; Particles (Nuclear physics) -- Mathematical models. ; Resonance.
The resonant excitation of low-frequency MHD waves by energetic ring current ions has been studied by means of hybrid MHD-gyrokinetic particle simulations. The purpose of the investigation is to identify the instability mechanism for internally...
Dartmouth Dissertations

Wave phenomena in the magnetosphere: auroral electromagnetic ion cyclotron waves and quasi-thermal electrostatic fluctuations.
Cyclotron waves. ; Plasma waves.
Dartmouth Dissertations

Isotopic evolution of a seasonal snowpack and its melt.
Snow -- Composition. ; Snow -- Mathematical models. ; Snow -- California. ; Snow -- Vermont. ; Stream measurements -- Mathematical models. ; Thawing -- Mathematical models. ; Oxygen -- Isotopes.
Dartmouth Dissertations

Structure and function of misfolded rhodopsin protein in Retinitis pigmentosa.
Retinitis pigmentosa -- Pathogenesis. Retinitis pigmentosa -- Genetic aspects. Rhodopsin. G proteins -- Receptors. Prostacyclin -- Receptors.
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
Dartmouth Dissertations

The synthesis and characterization of transition metal vinylidene complexes.
Vinylidene complexes. ; Transition metal compounds. ; Organometallic compounds.
Dartmouth Dissertations

Effects of the active auroral ionosphere on magnetosphere-ionosphere coupling.
Ionospheric radio wave propagation -- Mathematical models. ; Ionosphere -- Mathematical models. ; Magnetosphere -- Mathematical models. ; Auroras -- Mathematical models. ; Magnetosphere-ionosphere coupling. ; nasat.
The thesis is devoted to the effects of electromagnetic coupling between the Earth's magnetosphere and the active auroral ionosphere. The research has been focused, in particular, on the concept of ionospheric feedback instability. The feedback...
Dartmouth Dissertations

Characterization of metal ion binding to zinc finger peptides and metal ion competition reactions between metallothionein and Sp1 zinc finger #3.
Zinc-finger proteins. ; Metallothionein. ; Binding sites (Biochemistry).
Dartmouth Dissertations

Hybrid code simulation of electromagnetic ion cyclotron waves in curvilinear coordinates.
Cyclotron waves -- Mathematical models. Curvilinear coordinates. Nonlinear theories
Dartmouth Dissertations

Ionotropic glutamate receptor structure determination by electron microscopy.
Glutamic acid -- Receptors. Cell receptors -- Structure-activity relationships. Ligand binding (Biochemistry). Glutamates.
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) function as paracrine and autocrine receptors throughout the body. Most studies have focused on their role in fast excitatory neuronal signaling, and learning and memory. In...
Dartmouth Dissertations

Exploring new players in the Neurospora core clock and its output
The unifying theme of this work has been the use of forward genetics to identify three new genes - each thought to play an important yet unrecognized role in either the core circadian oscillator of Neurospora crassa , or in its main physiological...
Dartmouth Dissertations

The role of K⁺ channels and redox potential in the strain-dependent response to hypoxia.
Anoxemia -- Molecular aspects. Potassium channels. Oxidation-reduction reaction. Cell Hypoxia -- physiology.
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
Dartmouth Dissertations

Optical constants of ZnS and ZnS:Mn thin films from 1.5 eV to 3.2 eV as determined by transverse photothermal deflection spectroscopy.
Thin films -- Optical properties. Zinc sulfide -- Spectra.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Identification of steroid-binding and phosphorylated sites within the glucocorticoid receptor
Glucocorticoids -- Receptors; Phosphorylation; Steroid-binding proteins
Dartmouth Dissertations

Detection of hydrocarbons and hydrocarbon microseepage in the Bighorn Basin, Wyoming using isotopic, biogeochemical, and spectral reflectance techniques.
Hydrocarbons -- Secretion. Petroleum -- Geology -- Bighorn Basin (Mont. and Wyo.). Natural gas -- Geology -- Bighorn Basin (Mont. and Wyo.). Isotope geology -- Bighorn Basin (Mont. and Wyo.). Sagebrush -- Bighorn Basin (Mont. and Wyo.) -- Analysis....
Dartmouth Dissertations

The role of TonB-dependent receptors and alternate sigma factors in the Bradyrhizobium japonicum/soybean symbiosis.
Rhizobium -- Genetics. Cell receptors. Transcription factors. Bacteria.
Bradyrhizobium japonicum forms a nitrogen-fixing symbiosis with soybean. Signaling events, such as production of flavonoids and Nod factor, initiate the interaction, leading to formation of specialized root organs called nodules. A B. japonicum...
Dartmouth Dissertations

$Calculated one-dimensional X-ray diffraction patterns of illite/smectite as fundamental particle...$
Calculated one-dimensional X-ray diffraction patterns of illite/smectite as fundamental particle aggregates : implications for the structure of illite/smectite and for the smectite-to-illite transition
Illite -- Analysis. ; Smectite -- Analysis. ; X-ray crystallography
Dartmouth Dissertations

Synthesis of Elaeocarpus alkaloids via pyrrolinium ion trapping.
Elaeocarpaceae. ; Alkaloids -- Synthesis. ; Pyrrolizidines.
Dartmouth Dissertations

Applications of Cherenkov light emission for dosimetry in radiation therapy / by Adam Kenneth Glaser
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
Dartmouth Dissertations

Modeling geomagnetic storms on prompt and diffusive time scales / By Zhao Li
The discovery of the Van Allen radiation belts in the 1958 was the first major discovery of the Space Age. There are two belts of energetic particles. The inner belt is very stable, but the outer belt is extremely variable, especially during...
Dartmouth Dissertations

A study of neutral amino acid and drug transport in slices from human and rabbit placentae.
Placenta; Maternal-fetal exchange.
Dartmouth Dissertations

How sea ice microstructure influences the polar transport of salts from the ocean into the atmosphere / by Ross Lieb-Lappen
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
Dartmouth Dissertations

Measuring the seeds of thermal ion outflow / by Philip A. Fernandes
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Dartmouth Dissertations

Subcellular localization, turnover, and oligomerization studies of human acyl co-A: cholesterol acyltransferase (ACAT).
Acyltransferases. ; Cholesterol -- Synthesis. ; Cholesterol -- Genetic aspects.
Acyl coenzyme A: cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesteryl esters in various tissues. Recently, human ACAT cDNA has been cloned and expressed in this laboratory (Chang, C.C., et al, 1993, Cheng, D.;...
Dartmouth Dissertations