Dartmouth Digital Library Program

The essential bHLH transcription factor FIT1 regulates iron deficiency responses in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics. Transcription factors. Iron -- Metabolism. Iron deficiency diseases in plants -- Genetic aspects.
In order to preserve a balance between the requirement for iron and its toxicity, plants likely maintain tight control over iron homeostasis. We are interested in identifying factors involved in the regulation of iron uptake and have examined this...
Dartmouth Dissertations

The role of TonB-dependent receptors and alternate sigma factors in the Bradyrhizobium japonicum/soybean symbiosis.
Rhizobium -- Genetics. Cell receptors. Transcription factors. Bacteria.
Bradyrhizobium japonicum forms a nitrogen-fixing symbiosis with soybean. Signaling events, such as production of flavonoids and Nod factor, initiate the interaction, leading to formation of specialized root organs called nodules. A B. japonicum...
Dartmouth Dissertations

Development of new methods for the synthesis of indolines and quinolizidines / by Hui Li
I. (3 + 2) Cycloaddition Reactions of Oxyallyl Cationic Intermediates with Indoles Cyclopenta- and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 + 2) cycloaddition...
Dartmouth Dissertations

Molecular characterization of three ZIP metal transporters in Arabidopsis thaliana.
Arabidopsis thaliana -- Physiology. Zinc -- Physiological transport. Iron -- Physiological transport. Homeostasis. Trace elements in plant nutrition.
Iron and zinc are essential metal micronutrients that most humans acquire from plant-based diets. Unfortunately, plants are not a good source of these micronutrients, so billions of people worldwide suffer from deficiencies of these two elements....
Dartmouth Dissertations

Expression and recovery of recombinant proteins in a novel high cell density prokaryotic system based on Ralstonia eutropha.
Ralstonia -- Biotechnology. Microbial biotechnology. Industrial microbiology. Recombinant proteins -- Synthesis. Recombinant Proteins -- Biosynthesis.
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Dartmouth Dissertations

Iron acquisition and regulation in Bradyrhizobium japonicum.
Rhizobium -- Physiology. Rhizobium -- Genetics. Plants -- Effect of iron on.
Iron is essential in the agriculturally important symbiosis between Bradyrhizobium japonicum and soybean. Studying iron uptake in B. japonicum presents unique challenges in that the organism is found in two very different environments, free living...
Dartmouth Dissertations

Metal distribution in Arabidopsis.
Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
Dartmouth Dissertations

Gene transfer in thermophilic Clostridium.
Clostridium -- Biotechnology. ; Genetic transformation. ; Restriction enzymes DNA.
Dartmouth Dissertations

CD8 T cell responses to murine gamma-herpesvirus 68: viral persistence shapes the immune response.
T cells. Immunologic memory. Latent virus diseases -- Immunological aspects. Herpesvirus diseases. Cell-mediated cytotoxicity. CD8-Positive T-Lymphocytes -- immunology. T-Lymphocytes
Vaccines are one the greatest advances in public health. Vaccines work by priming cells of the adaptive immune system in such a way that they remember that they have encountered a specific antigen before. This then allows those cells to respond...
Dartmouth Dissertations

Characterization of molecular subsets of scleroderma using pathway analysis and animal models.
Scleroderma (Disease) -- Genetic aspects. Scleroderma (Disease) -- Molecular aspects. Cytokines -- Pathophysiology. Gene expression. Cellular signal transduction.
Scleroderma (systemic sclerosis; SSc) is a devastating autoimmune disease of unknown etiology for which there is no cure, and no truly effective therapies available. Immune dysfunction, fibrosis and vasculopathy are the three major features of the...
Dartmouth Dissertations

A novel high-cell-density recombinant protein production system based on Ralstonia eutropha.
Recombinant proteins -- Synthesis. Ralstonia. Alcaligenes eutrophus. Organophosphorus compounds -- Synthesis. Proteomics. Microbial biotechnology. Industrial microbiology. Recombinant Proteins -- Biosynthesis.
Recombinant protein production has traditionally relied on organisms with well developed molecular biological tools, such as E. coli. However, E. coli is not suited for large industrial scale production due to its propensity to produce organic...
Dartmouth Dissertations

Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.
Membrane fusion. Membrane proteins -- Physiological transport. Yeast fungi -- Cytology. Medical Term Vacuoles -- metabolism. Cytoplasmic Vesicles -- metabolism rab GTP-Binding Proteins -- metabolism Proteolipids -- metabolism
Yeast vacuole fusion requires 4 SNAREs, the Rab GTPase Ypt7p, vacuolar lipids, the SNARE complex disassembly machinery Sec17p and Sec18p, and the heterohexameric HOPS complex. Vacuole fusion occurs in stages: cis-SNARE complexes (bound to one...
Dartmouth Dissertations

Find results with:

		Thumbnail with title
		Grid with smaller thumbnails and more detail