Dartmouth Digital Library Program

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A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations

The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

Imaging performance in advanced small pixel and low light image sensors / by Leo Anzagira
The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
Dartmouth Dissertations

The role of BRCA1 in estrogen receptor-α regulation in breast cancer.
Breast -- Cancer -- Genetic aspects. ; Estrogen -- Receptors -- Regulation. ; Genetic transcription -- Regulation. ; BRCA1 Protein. ; Breast Neoplasms -- genetics. ; Gene Expression Regulation Neoplastic. ; Repressor Proteins.
Dartmouth Dissertations

Dependence of snow thermal and electrical conductiveness on microstructure.
Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Cation selectivity of IRT1: restricting cadmium uptake by plants.
Plant genetic engineering. ; Plants -- Effect of cadmium on. ; Cadmium -- Physiological transport.
Iron plays a central role in key biological processes in both plants and animals. Lack of available iron commonly limits plant growth and nutritional value. Worldwide, dietary iron is primarily obtained from plant sources and, despite our best...
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Metamorphism in east central Vermont.
Metamorphism (Geology) -- Vermont. ; Nappes (Geology) -- Vermont.
Dartmouth Dissertations

Hamiltonians, invariants and magnetic field-line topology.
Magnetic fields -- Mathematical models. ; Hamiltonian systems. ; Invariants.
Dartmouth Dissertations

Isolation of interleukin-2-induced immediate-early genes.
Interleukin-2.
Dartmouth Dissertations

Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
Interleukin-2. ; Mutagenesis.
Dartmouth Dissertations

A new vortex model for free boundary layer flows.
Fluid dynamics. ; Vortex-motion. ; Boundary layer.
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

Stratigraphy and structure of the Kennebago Lake quadrangle of central western Maine.
Geology, Stratigraphic. ; Geology -- Maine -- Kennebago Lake.
Dartmouth Dissertations

Large-scale structure of the universe: a clustering analysis.
Cosmology -- Mathematical models. ; Galaxies -- Clusters -- Mathematical models. ; Dark matter (Astronomy).
Dartmouth Dissertations

Mitochondrial biogenesis in Saccharomyces cerevisiae: transcriptional control by glucose.
Saccharomyces cerevisiae. ; Glucose. ; Mitochondria. ; Gene fusion. ; Cytochromes. ; Mutation (Biology).
Dartmouth Dissertations

High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Dartmouth Dissertations

Torsional movements in the large free living amoebae.
Amoeba. ; Torsion.
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Mapping ultramafic rocks by computer analysis of digital LANDSAT data.
Rocks Ultrabasic. ; Geology -- Data processing.
Dartmouth Dissertations

Mechanisms of the nephrotoxicity of acetaminophen studied in the mouse kidney cortex slice system.
Renal pharmacology. ; Acetaminophen. ; Mice -- Physiology.
Dartmouth Dissertations

Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
RNA -- Metabolism. ; Herpes simplex virus.
Dartmouth Dissertations

Interleukin-2 analogs with enhanced biological response: a novel ligand based mechanism.
Interleukin-2 -- Derivatives. ; Interleukin-2 -- Receptors. ; Ligand binding (Biochemistry).
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors (IL-2R) on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is...
Dartmouth Dissertations

Characterizing the roles of the central apparatus C1a projection complexes in motility regulation and axoneme assembly
The eukaryotic cilium (also called flagellum) is a complex, microtubule-based organelle that is found on many different cell types. It produces movement by the precise activation of dyneins that are located along the length and the circumference of...
Dartmouth Dissertations

Subcellular localization, turnover, and oligomerization studies of human acyl co-A: cholesterol acyltransferase (ACAT).
Acyltransferases. ; Cholesterol -- Synthesis. ; Cholesterol -- Genetic aspects.
Acyl coenzyme A: cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesteryl esters in various tissues. Recently, human ACAT cDNA has been cloned and expressed in this laboratory (Chang, C.C., et al, 1993, Cheng, D.;...
Dartmouth Dissertations

Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region.
Cytochrome P-450. ; Genetic regulation. ; Genetic transcription.
Dartmouth Dissertations

General observations and proteolytic enzyme activity in spores of the ostrich fern during the process of germination.
Matteuccia. ; Enzymes.
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

Three-dimensional reconstruction of noisy images from partially confocal scanning microscope.
Confocal microscopy. ; Image processing.
Dartmouth Dissertations

Evidence based practice in neonatal intensive care: the effect of prophylactic topical emollient ointment therapy and systemic antibiotic administration practices on nosocomial sepsis rates and mortality in extremely low birth weight infants 501 to...
Neonatal intensive care. ; Evidence-based medicine. ; Nosocomial infections -- Prevention. ; Ointments -- Effectiveness. ; Antibiotics -- Effectiveness.
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
Dartmouth Dissertations

Synthesis of highly fluorinated bicyclo [2.2.0] hex-2-ene derivatives.
Ketones. ; Fluorocarbons.
Dartmouth Dissertations

Gas diffusivity and air permeability of the firn from cold polar sites.
Snow -- Permeability. ; Snow surveys -- Antarctica -- East Antarctica. ; Surfaces -- Areas and volumes. ; Gas flow. ; Porosity.
Recent field investigations of a megadunes region of East Antarctica provide evidence that differences in grain size, thermal conductivity, and permeability across a megadune are due to relative accumulation patterns in the absence of significant...
Dartmouth Dissertations

Coordination chemistry and DNA-binding studies of a non-classical zinc finger motif.
Coordination compounds. ; Zinc-finger proteins. ; DNA-binding proteins. ; DNA-protein interactions.
Dartmouth Dissertations

Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
Dartmouth Dissertations

The role of p53 in retinoic acid-induced differentiation of human germ cell tumors.
p53 antioncogene -- Regulation. ; Retinoids -- Physiological effect. ; Retinoids -- Receptors. ; Cell differentiation -- Molecular aspects. ; Genetic transcription -- Regulation. ; Germ cells -- Tumors. ; Receptors.
The retinoids exert potent growth and differentiation effects on normal, embryonic and neoplastic cells. Although retinoids are known to regulate gene transcription through activation of retinoid receptors, the direct target genes of retinoid...
Dartmouth Dissertations

Moisture and temperature effects on the microwave dielectric behavior of soils.
Soils -- Effect of temperature on. ; Soils -- Electric properties. ; Dielectrics. ; Soil moisture -- Measurement.
Dartmouth Dissertations

Specificity in signaling : bacterial decision-making through the cyclic diguanylate second messenger / by Kurt M. Dahlstrom
Cyclic diguanylate (c-di-GMP) is a primarily bacterial and nearly universal second messenger used to stimulate a variety of responses from the cell by binding effector proteins. It is created by enzymes called diguanylate cyclases (DGCs) and broken...
Dartmouth Dissertations

Biological significance of VIVID photocycle length and the control of gene expression by the Neurospora clock / by Arko Dasgupta
Sensing light from the environment using photoreceptors is of great adaptive significance to eukaryotes. A prominent feature of the photochemistry of these receptors is the photocycle length, the time taken to decay from the initial signaling light...
Dartmouth Dissertations

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