Dartmouth Digital Library Program

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Magnet hospitals and patient outcomes.
Nursing services -- United States -- Evaluation. Nursing services -- United States -- Personnel management. Hospitals -- United States -- Administration. Outcome assessment (Medical care). Nursing Service.
Dartmouth Dissertations

Microwave imaging spectroscopy for breast cancer diagnosis.
Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

ID4 promotes the growth of glioblastoma multiforme by mediating MGP-enhanced angiogenesis.
Glioblastoma multiforme. DNA-binding proteins. Transcription factors. Extracellular matrix proteins. Neovascularization.
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Dartmouth Dissertations

In vivo fluorescence imaging and tomography methods to quantify metastatic burden in lymph nodes / by Alisha Viola DSouza
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Dartmouth Dissertations

The molecular basis for the carcinogenicity of nickel.
Nickel. ; Nickel compounds. ; Carcinogens.
Dartmouth Dissertations

Budding yeast discovery tools for neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to a variety of benign and malignant nervous system tumors. NF1 is caused by a mutation in the NF1 tumor suppressor gene, which encodes neurofibromin, a...
Dartmouth Dissertations

Localized spectroscopic imaging for the detection and discrimination of surgical breast tissue pathologies.
Two localized spectroscopic imaging methods were investigated to detect and discriminate microscopic pathologies at the surface of excised breast tissues in order to improve resection completeness during breast conserving surgery. A scanning in...
Dartmouth Dissertations

Broadband near-infrared tomography for breast cancer imaging.
Breast -- Cancer -- Tomography. Near infrared spectroscopy. Breast -- Cancer -- Imaging. Breast -- Cancer -- Diagnosis.
Near-infrared (NIR) light provides potential for a new approach to non-invasive detection, diagnosis and clinical management of breast cancer. Using NIR spectroscopic imaging techniques, the physiological information about breast tissue composition...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

Treatment planning software for the Dartmouth IMAAH system
Cancer -- Radiotherapy -- Computer programs; Microwave antennas -- Physiological effect -- Computer programs
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

FGF signaling and collagenase-1 expression in invasive melanoma cells.
Melanoma -- Genetic aspects. Fibroblast growth factors. Metalloproteinases -- Genetic aspects. Metalloproteinases -- Pathophysiology. Collagenases -- Genetic aspects. Collagenases -- Pathophysiology.
Melanoma progresses as a multi-step process, where the thickness of the lesion and depth of tumor invasion are the best prognostic indicators of clinical outcome. Degradation of the interstitial collagens in the extracellular matrix is an integral...
Dartmouth Dissertations

Electrical impedance tomography for breast imaging.
Electrical impedance tomography -- Equipment and supplies -- Design and construction. ; Breast -- Cancer -- Diagnosis. ; Breast -- Imaging.
Dartmouth Dissertations

Von Hippel Lindau (VHL) tumor suppressor regulation of MT1-MMP in renal cell carcinoma.
Antioncogenes. Metalloproteinases. Genetic regulation. Kidneys -- Cancer.
Dartmouth Dissertations

Immunomodulation and the prevention of pathogen-driven ileitis.
Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
Dartmouth Dissertations

Echocardiographic tissue characterization of normal, ischemic and infarcted myocardium.
Echocardiography. ; Heart -- Diseases -- Diagnosis.
Dartmouth Dissertations

Influence of stromal cells on uterine epithelial cell function: direct and indirect effects of estradiol on epithelial cell integrity and cytokine release.
Uterus -- Physiology. Epithelial cells. Cellular control mechanisms. Estradiol -- Physiological effect. Cytokines -- Physiological effect. Hepatocyte growth factor. Transforming growth factors-beta. Tumor necrosis factor. Stromal Cells --...
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
Dartmouth Dissertations

Three dimensional finite element simulations for regional electromagnetic hyperthermia treatment of cancer.
Cancer -- Treatment. ; Fever. ; Electromagnetic waves. ; Finite element method. ; Maxwell equations.
Dartmouth Dissertations

CD8 T cell responses to murine gamma-herpesvirus 68: viral persistence shapes the immune response.
T cells. Immunologic memory. Latent virus diseases -- Immunological aspects. Herpesvirus diseases. Cell-mediated cytotoxicity. CD8-Positive T-Lymphocytes -- immunology. T-Lymphocytes
Vaccines are one the greatest advances in public health. Vaccines work by priming cells of the adaptive immune system in such a way that they remember that they have encountered a specific antigen before. This then allows those cells to respond...
Dartmouth Dissertations

Growth regulation of rat hepatocytes by the liver tumor promoter ethinyl estradiol.
Ethinyl estradiol. ; Liver cells. ; Liver -- Growth.
Dartmouth Dissertations

Estimation of effective scatterer size and number density in near-infrared tomography.
Optical tomography. ; Mie scattering. ; Image analysis -- Mathematics. ; Breast -- Imaging. ; Diagnostic imaging.
Light scattering from tissue originates from the fluctuations in intra-cellular and extra-cellular components, so it is possible that macroscopic scattering spectroscopy could be used to quantify sub-microscopic structures. Both electron microscopy...
Dartmouth Dissertations

Regulation of constitutive MMP-1 expression by the ERK signaling cascade in tumor cells.
Metalloproteinases -- Genetic aspects. ; Metalloproteinases -- Pathophysiology. ; Cellular signal transduction. ; Breast -- Cancer -- Genetic aspects. ; Protein kinases -- Genetic aspects. ; Extracellular matrix proteins. ; Extracellular...
Matrix metalloproteinase-1 (MMP-1) expression is controlled by the mitogen activated protein kinase (MAPK) pathway(s) via the activity of activator protein-1 (AP-1) and polyoma enhancing activity-3/E26 virus (PEA3/ETS) transcription factors through...
Dartmouth Dissertations

Optical spectroscopy guided by structural and functional MRI for breast cancer imaging.
Optical spectroscopy. Magnetic resonance imaging. Breast -- Cancer -- Imaging.
Magnetic Resonance (MR)-guided Diffuse Optical Imaging is an emerging technique to improve breast cancer imaging. This modality combines the high sensitivity of breast MR with images of tissue physiology, including blood content, oxygen saturation,...
Dartmouth Dissertations

Computational aspect of tomographic microwave imaging for biomedical applications
Microwave imaging (MI) is based on recovering dielectric properties (permittivity and conductivity) of materials. Over the last two decades, MI has attracted increasing interests in biomedical applications, in particular, for breast cancer...
Dartmouth Dissertations

Later stage brain deformation compensation in image-guided neurosurgery
In image-guided neurosurgery, preoperative magnetic resonance images (pMR) are typically used intraoperatively for neuronavigation. The accuracy of image guidance using preoperative images can be significantly compromised by intraoperative brain...
Dartmouth Dissertations

Local hyperthermia and nanoparticle targeting for cancer immunotherapy / by Seiko Toraya Brown.
Local hyperthermia treatment for cancer has been used clinically in combination with and to enhance the efficacy of traditional treatments such as chemotherapy and radiation. In association with recent understanding of the importance of stimulating...
Dartmouth Dissertations

Investigation of the ISG15 deisgylase UBP43 in carcinogenesis : tumor suppressor or oncogene? / by Fadzai Chinyengetere.
ISGylation is a type 1 interferon-regulated process that involves conjugation of ISG15, an ubiquitin-like protein, to target proteins. This posttranslational modification is reversed by a deubiquitinase known as UBP43 or USP18. UBP43 is deregulated...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Assortativity and the robustness of gene regulatory networks / by Dov A. Pechenick.
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
Dartmouth Dissertations

Structure and function of cytosolic glucocorticoid receptors in rodent lymphoid cells : studies in receptor stability, subunit composition, and phosphorylation
Cell receptors; Glucocorticoids; Phosphorylation
Dartmouth Dissertations

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