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All fields: mitochondrial

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- A complex of the BCL2-like protein CED-9 and the BH3-only protein EGL-1 recruits DRP-1 to mitochondria and promotes mitochondrial fission
- Mitochondria -- Physiology.; Fission (Biology) ; Guanosine triphosphatase. ; Caenorhabditis elegans. ; Caenorhabditis elegans Proteins -- physiology. ; GTP Phosphohydrolases -- physiology. ; bcl2-Associated Death Protein -- physiology.
- Dartmouth Dissertations
- Monitoring late radiation damage in normal muscle tissue with electrical impedance spectroscopy.
- Muscle cells -- Effect of radiation on. ; Radiation -- Physiological effect. ; Electrical impedance tomography. ; Spectroscopic imaging.
- Dartmouth Dissertations
- Conservation and evolution of DNA regulatory signal patterns
- Dartmouth Dissertations
- A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
- NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
- Dartmouth Dissertations
- Metal distribution in Arabidopsis.
- Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
- Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
- Dartmouth Dissertations
- The study of an endonuclease and its potential role in apoptosis.
- Deoxyribonucleases. ; Endonucleases. ; Apoptosis.
- Previous work in this laboratory has implicated deoxyribonuclease II (DNase II) as an endonuclease responsible for DNA digestion during apoptosis. The goal of this thesis was to isolate the cDNA encoding DNase II and study its potential role in...
- Dartmouth Dissertations
- The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
- Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
- Dartmouth Dissertations
- Investigation of the requirements for transitional endoplasmic reticulum (tER) site structure and function in Saccharomyces cerevisiae.
- Endoplasmic reticulum.; Membrane proteins -- Physiological transport. ; Coated vesicles. ; Golgi apparatus. ; Saccharomyces cerevisiae -- Molecular aspects. ; Phospholipids -- Physiological effect. ; Saccharomyces cerevisiae Proteins. ; COP-Coated...
- Eukaryotic cells contain distinct membrane-bound organelles that house sets of specialized metabolic reactions. The network of controlled communications between organelles is known as the secretory pathway. Transport of proteins and lipids between...
- Dartmouth Dissertations
- The purification and characterization of a three-subunit ubiquinol-cytochrome c oxidoreductase complex from Paracoccus denitrificans.
- Cytochrome c. ; Paracoccus denitrificans.
- Dartmouth Dissertations
- An investigation into the mechanism of action of aldosterone on ENaC: A search for endogenous substrates of SGK1.
- Subject Protein kinases. Aldosterone -- Physiological effect. Sodium -- Physiological transport. Sodium channels. Epithelial cells. Glucocorticoids. Medical Term Sgk protein.
- It is well established that SGK1 plays a role in aldosterone mediated sodium transport. The intracellular localization of SGK1 has recently been demonstrated as mitochondrial. The studies described here evaluate the hypothesis that SGK1...
- Dartmouth Dissertations
- New pathways of NAD+ metabolism and longevity.
- NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
- NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
- Dartmouth Dissertations
- Subcellular location and function studies of the serum and glucocorticoid induced kinase-1 (SGK1).
- Protein kinases -- Mechanism of action. Sodium channels -- Genetic aspects. Glucocorticoids. Acetylation. Histones. Sgk protein. Receptors
- The serum and glucocorticoid induced kinase 1 (SGK1) is involved in aldosterone-induced Na + reabsorption by increasing epithelial Na + channel (ENaC) activity in cortical collecting duct (CCD) cells. We found the SGK1-GFP fusion protein is...
- Dartmouth Dissertations
- Graduate Poster Session: posted April 18, 2014 on ...
- Dartmouth College Photographic Records
- Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
- Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
- Dartmouth Dissertations
- Electron paramagnetic resonance spectroscopy of chromium compounds.
- Chromium compounds. Electron paramagnetic resonance spectroscopy.
- Dartmouth Dissertations
- The interplay between BCL2 family members in response to pharmacologically induced apoptosis
- Apoptosis.; Cancer cells -- Growth -- Regulation. ; Cellular signal transduction. ; Apoptosis Regulatory Proteins -- pharmacology. ; Proto-Oncogene Proteins c-bcl-2 -- pharmacology. ; bcl2-Associated Death Protein -- pharmacology. ; Vinblastine --...
- Dartmouth Dissertations
- Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
- All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
- Dartmouth Dissertations
- Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
- Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
- Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
- Dartmouth Dissertations
- Interactions between the carcinogen chromium(VI) and DNA.
- DNA. ; Chromium. ; Thiols.
- Dartmouth Dissertations
- Subcellular localization, turnover, and oligomerization studies of human acyl co-A: cholesterol acyltransferase (ACAT).
- Acyltransferases. ; Cholesterol -- Synthesis. ; Cholesterol -- Genetic aspects.
- Acyl coenzyme A: cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesteryl esters in various tissues. Recently, human ACAT cDNA has been cloned and expressed in this laboratory (Chang, C.C., et al, 1993, Cheng, D.;...
- Dartmouth Dissertations
- The retinoid inducible nuclear receptor coregulator, RIP140: a limiting factor in retinoid and estrogen signaling.
- Antineoplastic agents. Tretinoin. Nuclear receptors (Biochemistry). Genetic regulation.
- Dartmouth Dissertations
- Light and circadian regulation in Neurospora crassa.
- Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
- Dartmouth Dissertations
- Fluorescence in situ hybridization studies of shared human chromosome 17 synteny in the Canidae.
- Canidae -- Genome mapping. ; Human gene mapping. ; DNA probes. ; Hybridization. ; Linkage (Genetics).
- Dartmouth Dissertations
- Biochemical and genetic characterization of subunit six from the Saccharomyces cerevisiae cytochrome bc[subscript 1] complex.
- Cytochrome c. ; Peptides. ; Saccharomyces cerevisiae.
- Dartmouth Dissertations
- Studies on the basis of the toxicity of aliphatic organonitriles.
- Nitriles -- Toxicology. ; Polyamines.
- Dartmouth Dissertations
- Proteins of rat liver lysomal membranes: characterization, biosynthesis and comparison with plasma membranes.
- Lysosomes. ; Cell membranes.
- Dartmouth Dissertations
- Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
- Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
- Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
- Dartmouth Dissertations
- Isolation and characterization of the nuclear gene and gene product of COX12, the gene encoding subunit VIb of cytochrome c oxidase of Saccharomyces cerevisiae.
- Cytochrome oxidase -- Genetic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Molecular microbiology.
- Dartmouth Dissertations
- Molecular cloning and analysis of arg-13, os-1 and prd-4 in Neurospora crassa.
- Molecular cloning. ; Circadian rhythms. ; Neurospora crassa.
- Dartmouth Dissertations
- Studies on the mode of action of glucocorticoids in islated rat tymus cells: investigations into the latency and site of corticol inhibition of glucose uptake and glucose 6-phosphate accumulation.
- Glucocorticoids.
- Dartmouth Dissertations
- Studies on the mechanism of action of glucocorticoids in rat thymus cells in vitro: examination of cortisol and cortisone binding in various tissues and the identification and extraction of an intracellular physiological glucocorticoid receptor.
- Glucocorticoids.
- Dartmouth Dissertations
- Localized spectroscopic imaging for the detection and discrimination of surgical breast tissue pathologies.
- Two localized spectroscopic imaging methods were investigated to detect and discriminate microscopic pathologies at the surface of excised breast tissues in order to improve resection completeness during breast conserving surgery. A scanning in...
- Dartmouth Dissertations
- Chloroplasts, mitochondria and iron homeostasis: a role for ferric chelate reductases and an efflux transporter.
- Plants -- Effect of iron on. Iron -- Metabolism -- Molecular aspects. Chloroplasts. Plant mitochondria. Homeostasis. Plant enzymes. Reduction (Chemistry). Iron chelates.
- Dartmouth Dissertations
- Regulation of apoptosis in the Caenorhabditis elegans nervous system.
- Caenorhabditis elegans -- Genetics. Neurons. Apoptosis. Genetic transcription -- Regulation.
- Most of the cells that die during the development of a C. elegans hermaphrodite do so within 30 min after being generated. In these cells, the pro-caspase proCED-3 is inherited from progenitors and the transcriptional upregulation of the BH3-only...
- Dartmouth Dissertations
- The evolution of metazoan microRNA genes and the advent of vertebrate complexity
- Vertebrates -- Evolution.;""Vertebrates -- Molecular genetics."";""Cyclostomata (Bryozoa) -- Evolution."";""Cyclostomata (Bryozoa) -- Molecular genetics."";""Metazoa -- Evolution."";""Metazoa -- Molecular genetics."";""Non-coding RNA."";""MicroRNAs...
- Dartmouth Dissertations
- Role of Whi3 protein aggregation behavior in cell-cycle regulation and cell polarity / by ChangHwan Lee.
- Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle...
- Dartmouth Dissertations
- Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
- The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
- Dartmouth Dissertations
- Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
- Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
- Dartmouth Dissertations
- Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
- Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
- Dartmouth Dissertations
- The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
- Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations
- Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
- Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
- Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
- Dartmouth Dissertations
- Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
- Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
- Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
- Dartmouth Dissertations
- Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
- The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
- Dartmouth Dissertations
- Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
- Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
- Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
- Dartmouth Dissertations
- Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
- Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
- Dartmouth Dissertations
- Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
- Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
- Dartmouth Dissertations
- The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
- Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
- Dartmouth Dissertations

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