Dartmouth Digital Library Program

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Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Binary responses to numerical stimuli.
Senses and sensation. ; Psychometrics. ; Perception.
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

Computational methods for microwave medical imaging.
Microwave imaging -- Mathematics. ; Three-dimensional imaging -- Mathematics. ; Image reconstruction -- Mathematics. ; Microwave imaging in medicine. ; Computer algorithms.
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Dartmouth Dissertations

Morphological, semantic and formal relationships in the organisation of the mental lexicon.
Learning, Psychology of. ; Psycholinguistics.
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Monitoring late radiation damage in normal muscle tissue with electrical impedance spectroscopy.
Muscle cells -- Effect of radiation on. ; Radiation -- Physiological effect. ; Electrical impedance tomography. ; Spectroscopic imaging.
Dartmouth Dissertations

Estimation of effective scatterer size and number density in near-infrared tomography.
Optical tomography. ; Mie scattering. ; Image analysis -- Mathematics. ; Breast -- Imaging. ; Diagnostic imaging.
Light scattering from tissue originates from the fluctuations in intra-cellular and extra-cellular components, so it is possible that macroscopic scattering spectroscopy could be used to quantify sub-microscopic structures. Both electron microscopy...
Dartmouth Dissertations

Peer education in eating disorder prevention: a large scale longitudinal analysis of program effectiveness.
Eating disorders -- Prevention -- Longitudinal studies. ; Eating disorders -- Treatment. ; Peer counseling of students.
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Dartmouth Dissertations

Chemico-physical and pharmacologic factors that influence delivery of IONPs to tumors in rodent breast cancer models / by Jennifer Tate.
Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
Dartmouth Dissertations

Microbial mediation of plant-pollinator interactions / by Robert N. Schaeffer II.
Floral nectar of many plant species is prone to colonization by microorganisms. Their presence and metabolism have the potential to modify a suite of traits important for pollinator attraction, including nectar quality and scent. However, studies...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Magnetic susceptibility imaging of magnetic nanoparticles / by Bradley W. Ficko.
Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Dartmouth Dissertations

Quantifying optical tomography methods for biomolecular sensing / by Jennifer-Lynn H. Demers.
Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
Dartmouth Dissertations

Characterization of short latency respiratory-related evoked potentials (RREPs) recorded using a noncephalic reference.
Respiration -- Regulation. Respiratory organs -- Physiology. Neurophysiology.
Dartmouth Dissertations

An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
Dartmouth Dissertations

Nocturnality and defense in the rat: selective association of light and aversive stimulation.
Rats -- Behavior. Nocturnal animals. Defensiveness (Psychology). Aversive stimuli.
Dartmouth Dissertations

Treatment planning software for the Dartmouth IMAAH system
Cancer -- Radiotherapy -- Computer programs; Microwave antennas -- Physiological effect -- Computer programs
Dartmouth Dissertations

Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

Electrical impedance imaging for temperature field estimation during hyperthermia treatment of cancer.
Electrical impedance tomography. Newton-Raphson method. Cancer -- Thermotherapy -- Technique.
Dartmouth Dissertations

Microwave imaging for 2-D electrical property distribution profiling.
Image reconstruction. Microwave imaging. Microwave imaging -- Instruments -- Design and construction. Microwave imaging in medicine.
Dartmouth Dissertations

Semantic integration in sentence memory
Memory. Semantics. Recognition (Psychology)
Dartmouth Dissertations

Bilingual and monolingual brains compared: a fMRI study of semantic processing.
Bilingualism -- Physiological aspects. ; Neurolinguistics. Cognition -- Physiological aspects. ; Brain -- Localization of functions.
Does early and sustained experience with two languages in childhood modify how language is processed in the adult bilingual brain? Does extensive exposure to two languages influence language processing in the bilingual brain as compared to...
Dartmouth Dissertations

A generalized least-squares minimization method for near infrared diffuse optical tomography.
Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
Dartmouth Dissertations

Microwave tomographic imaging using dielectric contrast in temperature and tissue content
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.
Dartmouth Dissertations

Habituation in school-age children.
Habituation (Neuropsychology). ; Child psychology.
Dartmouth Dissertations

Mechanisms of feeling of knowing in memory.
Memory -- Testing. ; Psychology Experimental.
Dartmouth Dissertations

The inverse hyperthermia problem and its solution.
Thermotherapy.
Dartmouth Dissertations

Coding of disparity as a function of directional separation and feature similarity.
Vision -- Research. ; Visual perception.
Dartmouth Dissertations

Applications of Cherenkov light emission for dosimetry in radiation therapy / by Adam Kenneth Glaser
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
Dartmouth Dissertations

Cherenkov imaging and biochemical sensing in vivo during radiation therapy / by Rongxiao Zhang
While Cherenkov emission was discovered more than eighty years ago, the potential applications of imaging this during radiation therapy have just recently been explored. With approximately half of all cancer patients being treated by radiation at...
Dartmouth Dissertations

The mental workspace as a distributed neural network / by Alexander Schlegel
The brain is a vastly interconnected information processing network. In humans, this network supports the rich mental space at the root of the imagination and enables many flexible cognitive abilities such as scientific and artistic creativity. How...
Dartmouth Dissertations

The novel p53 target gene STK17A : implications for cancer therapy / by Pingping Mao
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Dartmouth Dissertations

Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
Dartmouth Dissertations

The sturucture and function of brain networks underlying self-evaluation / by Robert S. Chavez
Humans have a seemingly unique capacity to reflect upon information about the self to form evaluative attitudes that influence their quality of life and predict mental health outcomes. While psychologists have devoted decades of research to the...
Dartmouth Dissertations

Microwave imaging spectroscopy for breast cancer diagnosis.
Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
Dartmouth Dissertations

In vivo fluorescence imaging and tomography methods to quantify metastatic burden in lymph nodes / by Alisha Viola DSouza
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Dartmouth Dissertations

Contributions of retrosplenial cortex to associative learning and memory.
Cerebral cortex -- Psychophysiology. Learning.
Neuroanatomical studies have defined two relatively separate corticohippocampal processing streams that contribute substantially to medial temporal lobe function. Among the cortical regions providing significant input to these processing streams is...
Dartmouth Dissertations

Sensing eye position.
Saccadic eye movements. ; Eye -- Movements. ; Visual perception -- Physiological aspects. ; Senses and sensation.
The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
Dartmouth Dissertations

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