Dartmouth Digital Library Program

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Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

The chronology and stratigraphic evolution of the Kashmir and Peshawar intermontane basins, northwestern Himalaya.
Geology, Stratigraphic. Geology -- India -- Kashmir Vale of. Geology -- Pakistan -- Peshawar.
Dartmouth Dissertations

The population dynamics, bioenergetics, and nutrient cycling of three species of mice in the Hubbard Brook Experimental Forest, New Hampshire, U.S.A
Mice; Forest ecology -- New Hampshire. ; Animal ecology -- New Hampshire
Dartmouth Dissertations

Soil biogeochemistry in temperate and arctic ecosystems : human disturbances to a critical carbon pool / by Chelsea L. Petrenko
I investigated the effects of two contemporary disturbances to soil systems: forest clearing in the northeastern U.S. and climate-driven plant succession in the Arctic. To test the effects of clear-cutting forests on mineral soil carbon (C)...
Dartmouth Dissertations

The experimental analysis of mutlitple computationally-driven methods for the deletion of broadly distributed T cell epitopes in a functional biotherapeutic candidate / by Regina Salvat
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
Dartmouth Dissertations

Factors controlling the seasonal abundance and distribution of Calanus finmarchicus in the Gulf of Maine/Georges Bank Region.
Calanus finmarchicus -- Georges Bank. ; Calanus finmarchicus -- Maine Gulf of. ; Calanus finmarchicus -- North Atlantic Ocean.
Calanus finmarchicus, a kind of marine zooplankton, plays an important ecological role throughout the North Atlantic. Striking seasonal variations exist in its abundance and distribution in the Gulf of Maine/Georges Bank region. On the Bank in...
Dartmouth Dissertations

Uplift and cooling history of the NW Himalaya, Northern Pakistan: evidence from fission-track and 40Ar/39Ar cooling ages.
Geology -- Himalaya Mountains. ; Geology -- Pakistan. ; Fission track dating.
Dartmouth Dissertations

Automatic spectral classification.
Stars -- Spectra -- Classification. Stars -- Open clusters.
Dartmouth Dissertations

A role for membrane fusion in the activation of the respiratory burst in human neutrophils.
Membrane fusion. Oxidases. Neutrophils.
Dartmouth Dissertations

Habitat selection by breeding black-throated blue warblers: different patterns at two spatial scales and the use of habitat for foraging and nesting.
Black-throated blue warbler -- Habitat. Black-throated blue warbler -- Behavior. Black-throated blue warbler -- Food. Black-throated blue warbler -- Nests.
Dartmouth Dissertations

Reconstructed near infrared diffusion imaging for breast cancer detection.
Infrared imaging. Image reconstruction. Optical images -- Mathematical models. Breast -- Imaging. Infrared radiation in medicine.
Finite element based reconstruction algorithms for optical property profiling in biological tissues have been developed, implemented and evaluated using simulated data and laboratory measurements obtained with near infrared continuous wave (cw) and...
Dartmouth Dissertations

Facial expressions and identity as social cues for biologically relevant learning
Facial expression.; Threat (Psychology) ; Amygdaloid body -- Psychophysiology. ; Learning Psychology of. ; Memory. ; Attention.
The experiments comprising this thesis aimed to characterize the neural and behavioral correlates of learning about and responding to the predictive information conveyed by social cues. Facial expressions are cues that convey critical information...
Dartmouth Dissertations

The synthesis and chemistry of highly fluorinated cyclopentadienes.
Cyclopentadiene. ; Organofluorine compounds.
Dartmouth Dissertations

Assessing communication skills in medical education: development of the patient video interview.
Medicine -- Study and teaching -- Audio-visual aids. ; Communication -- Audio-visual aids. ; Medical history taking. ; Physician and patient. ; Psychometrics.
The Patient Video Interview (PVI) is an instrument designed to assess communication skills in medical education that overcomes some of the drawbacks of other assessment methods. Three studies were conducted to: (a) determine a measurement system...
Dartmouth Dissertations

Single nucleotide polymorphisms in the human prostacyclin gene: implications for cardiovascular disease and genetic mutagenesis.
Prostacyclin -- Receptors. Chromosome polymorphism. Cardiovascular system -- Diseases -- Genetic aspects. Polymorphism.
Prostacyclin (PGI 2 ) is a major product of COX-2 catalyzed metabolism of arachidonic acid in the endothelium and has been shown to be atheroprotective. PGI 2 signals though its G-coupled protein receptor (GPCR) the human Prostacyclin receptor...
Dartmouth Dissertations

Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
Dartmouth Dissertations

C₂-Symmetric Bis(phosphines) and Their Metal Complexes : Synthesis, Materials Application, and Screening Racemic Catalysts / Sanderson, Matthew David
Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions; II. Synthesis of pyrrolo[3,4-b]indoles.
Indole -- Synthesis. Indole -- Reactivity. Pyrroles. Diels-Alder reaction.
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

A geologic study of the Chagai Hills, Baluchistan, Pakistan using LANDSAT digital data.
Geology -- Pakistan -- Balochistan -- Chagai Hills.
Dartmouth Dissertations

On the density of abundant numbers.
Number theory. ; Numbers Natural. ; Algorithms.
Dartmouth Dissertations

Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

An optical search for supernova remnants in nearby spiral galaxies.
Supernova remnants. ; Spiral galaxies -- Optical properties. ; Optical detectors.
Dartmouth Dissertations

Coping in context: a longitudinal analysis of the relationship between emotion and coping in two stressful situations.
Adjustment (Psychology) -- Testing. ; Affect (Psychology) -- Testing. ; Context effects (Psychology). ; Life change events. ; Stress (Psychology).
Dartmouth Dissertations

$Stark-geometry photorefractive multiple quantum well spatial light modulators.$
Stark-geometry photorefractive multiple quantum well spatial light modulators.
Light modulators -- Mathematical models. ; Quantum wells. ; Photorefractive materials. ; Optoelectronic devices -- Mathematical models.
Stark-geometry photorefractive multiple quantum well (PR-MQW) spatial light modulators (SLMs) show promise for several optoelectronic applications such as high-speed image correlation and real-time 3-D holographic imaging. Their performance is...
Dartmouth Dissertations

Modeling of shocks in young and old supernova remnants.
Supernova remnants. Shock waves -- Mathematical models. Interstellar matter.
We present results from a modeling effort of simple shock phenomena in the Cygnus Loop and Cassiopeia A. Using multi-epoch MDM observations of a small, isolated cloud in the southwest region of the Cygnus Loop, we measure the velocity of the...
Dartmouth Dissertations

Conversion of paper sludge to ethanol and analysis of selection based strain improvement for recombinant Saccharomyces cerevisiae expressing saccharolytic enzymes through continuous culture.
Cellulase -- Biotechnology. ; Hydrolysis. ; Paper industry -- Technological innovations. ; Biomass energy -- Economic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Enzymes -- Industrial applications.
Paper sludge is the largest solid waste stream produced by pulp and paper industry, and is also an attractive feedstock for emergent technologies based on processing of cellulosic biomass featuring enzymatic hydrolysis. This study focuses on...
Dartmouth Dissertations

A versatile approach to ellipticine and its analogues: Preparation and free radical reactions of 2-bromo-3-substituted indoles.
Alkaloids -- Synthesis. ; Heterocyclic compounds -- Synthesis. ; Indole.
Dartmouth Dissertations

Structural and functional characterization of Runx1 point mutations identified in leukemia and cleidocranial dysplasia patients.
Transcription factors -- Pathophysiology. Hematopoiesis -- Genetic aspects. Genetic transcription -- Regulation. DNA-binding proteins. Leukemia -- Genetic aspects. Core Binding Factor Alpha 2 Subunit. Core Binding Factor beta Subunit. Cleidocranial...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
Dartmouth Dissertations

Synchrotron X-ray topographic studies of polycrystalline ice.
Ice crystals -- Radiography. ; Synchrotron radiation. ; Dislocations in crystals.
Dartmouth Dissertations

Local and landscape-scale controls on the distribution and abundance of a headwater stream salamander.
Gyrinophilus -- Ecology. ; Gyrinophilus -- Geographical distribution -- Northeastern States. ; Freshwater ecology -- Northeastern States. ; Amphibian populations -- Northeastern States.
I investigated controls on the distribution and abundance of the salamander Gyrinophilus porphyriticus (Plethodontidae) acting at multiple spatial scales: individual first-order streams, headwater drainages comprised of multiple streams, and the...
Dartmouth Dissertations

Chronostratigraphic variability in fluvial sequences as revealed by paleomagnetic isochrons: examples in Miocene strata from a central Andean intermontane basin (Salla, Bolivia) and the northwest Himalayan foreland (lower Siwalik Group, Chinji...
Stratigraphic correlation -- Bolivia. ; Stratigraphic correlation -- Pakistan. ; Geology Stratigraphic -- Miocene. ; Sedimentology.
Dartmouth Dissertations

The role of CD40 and its ligand in transplant tolerance.
CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Dartmouth Dissertations

Design and testing of Cerenkov free electron lasers in the far infrared.
Free electron lasers -- Design and construction. ; Cherenkov radiation. ; Infrared radiation. ; Far infrared lasers -- Design and construction.
Dartmouth Dissertations

Self-consistent stellar evolution models with applications to Milky Way globular clusters and population synthesis.
Stars -- Evolution. Stars -- Globular clusters -- Computer simulation. Milky Way.
The Dartmouth Stellar Evolution Program, a state of the art stellar evolution code, has been modified and expanded to increase its versatility. The modifications include: the ability to self-consistently model stars with arbitrary chemical...
Dartmouth Dissertations

Budding yeast discovery tools for neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to a variety of benign and malignant nervous system tumors. NF1 is caused by a mutation in the NF1 tumor suppressor gene, which encodes neurofibromin, a...
Dartmouth Dissertations

Analysis of inpatient surveillance data for automated classification of deterioration.
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Dartmouth Dissertations

Magnet hospitals and patient outcomes.
Nursing services -- United States -- Evaluation. Nursing services -- United States -- Personnel management. Hospitals -- United States -- Administration. Outcome assessment (Medical care). Nursing Service.
Dartmouth Dissertations

Microfabricated thin-film inductors for high-frequency DC-DC power conversion
Electric inductors -- Design and construction.;""DC-to-DC converters -- Design and construction."";""Thin film devices -- Design and construction."";""Microfabrication."";""Magnetic films."";""Thin films Multilayered."";""Granular...
Dartmouth Dissertations

Examining the association between early social fear, social anxiety symptoms and cigarette smoking among young adults
Background Smoking is the number one cause of preventable premature death and disease. Social anxiety disorder is strongly associated with nicotine dependence in adults. The aims of this research were to determine whether social anxiety symptoms...
Dartmouth Dissertations

Leading quality care transformation through involving everyone in improving care
Background: With the science and transparency of quality measurement unfolding, and economic forces changing, hospital leaders seek to aggressively improve their systems' care quality. Successful organizational transformations will engage everyone...
Dartmouth Dissertations

Investigating the scale-up of anaerobic soluble sugar fermentations for large-scale ethanol production.
Alcohol -- Synthesis -- Computer simulation. Corn -- Biotechnology. Fermentation -- Computer simulation. Alcohol as fuel. Computational fluid dynamics.
Renewable energy sources are becoming increasingly important as sustainable alternatives to fossil fuels. One of these renewable sources, cellulosic biomass, is a relatively inexpensive and abundant resource that can be converted into liquid fuels...
Dartmouth Dissertations

Role of melanin concentrating hormone (MCH) containing neurons in the lateral hypothalamus in cardiorespiratory control and energy balance / by Ningjing Li.
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral...
Dartmouth Dissertations

Improvement and evaluation of nonlinear inversion MR elastography / by Matthew D. J. McGarry.
Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
Dartmouth Dissertations

Synthetic studies of Munchnone reactivity and applications and the total synthesis of cyclopenta[B]indole natural products / by Justin M. Lopchuk.
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Dartmouth Dissertations

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