Dartmouth Digital Library Program

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Spectral studies of the enzyme rhodanese.
Enzymes.
Dartmouth Dissertations

HSET motor function during mammalian mitosis and meiosis.
Tubulins. ; Microtubules. ; Cell division. ; Kinesin. ; Cytoskeletal proteins. ; Microtubule-Associated Proteins.
Microtubule motors are essential for cell division. Although the functions of some mitotic motor proteins have been elucidated, the precise mechanisms by which they govern spindle assembly and chromosome segregation remain largely unknown. This...
Dartmouth Dissertations

Decentralized adaptive control for nonlinear interconnected systems with applications to real-time robot control.
Robots -- Control systems. ; Control theory. ; Robotics.
Dartmouth Dissertations

An experimental and computational study of binary optical elements for aberration correction in three-dimensional fluorescence microscopy.
Fluorescence microscopy. ; Fourier transform optics. ; Optical instruments -- Design and construction. ; Photolithography.
Dartmouth Dissertations

Perceptual learning in audition.
Perceptual learning. ; Auditory perception.
Classical threshold theory assumes that a threshold is fixed and immutable. It cannot explain nor predict the underlying mechanisms for any changes in threshold value due to training. However, increased sensitivity to sensory signals through...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Radial infall dynamics of a simulated rich cluster of galaxies.
Galaxies -- Clusters -- Mathematical models. ; Galactic halos -- Mathematical models.
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Investigation, optimization and synthesis of dihydrodipyrrins, linear tetrapyrroles and the resulting chlorins.
Porphyrins -- Synthesis. Tetrapyrroles -- Synthesis.
The synthesis of macrocyclic tetrapyrroles continues to be an area of vigorous research due to their application to a wide range of fields spanning the physical sciences. Only recently have general syntheses for the reduced systems, such as...
Dartmouth Dissertations

CD8 T cell responses to murine gamma-herpesvirus 68: viral persistence shapes the immune response.
T cells. Immunologic memory. Latent virus diseases -- Immunological aspects. Herpesvirus diseases. Cell-mediated cytotoxicity. CD8-Positive T-Lymphocytes -- immunology. T-Lymphocytes
Vaccines are one the greatest advances in public health. Vaccines work by priming cells of the adaptive immune system in such a way that they remember that they have encountered a specific antigen before. This then allows those cells to respond...
Dartmouth Dissertations

On the nature of the photoconductivity in ice.
Ice. ; Photoconductivity. ; Ice crystals -- Growth. ; Ice -- Plastic properties -- Effect of ultraviolet radiation on.
Dartmouth Dissertations

Role of Erv14p in vesicle mediated protein transport from the endoplasmic reticulum to the Golgi in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Transport vesicles form at a donor compartment and fuse to an acceptor compartment mediate the movement of cargo proteins within eukaryotic cells from one subcellular compartment to another. COPII vesicles specifically provide the means of...
Dartmouth Dissertations

Modeling process-dependent gate dielectrics for silicon devices.
Dielectric devices -- Reliability. ; Silicon. ; Gate array circuits. ; Ellipsometry.
Dartmouth Dissertations

Novel levels of Ras1 regulation in the human fungal pathogen, Candida albicans / by Amy Elizabeth Piispanen.
Neurotrophic functions.;""Growth factors."";""Exercise -- Physiological aspects."";""Cognition -- Effect of exercise on."";""Cognition -- physiology.""
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Biochemistry of dioxygenated triterpenoids and steroids.
Cholesterol. Squalene. Steroids.
Dartmouth Dissertations

Determining anthropogenic and natural controls on the global mercury cycle using lake sediment and ice cores ; by Samuel Adams Beal Jr.
While anthropogenic emissions of the toxic element mercury (Hg) to the atmosphere are currently rising, major uncertainties remain in determining the relative impacts of anthropogenic activity and natural processes on the global Hg cycle. In this...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
Dartmouth Dissertations

Automatic test pattern generation techniques for built-in self-test of digital circuits.
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
Dartmouth Dissertations

A new synthetic route to B-ring derivatives of TMD
Bicyclic compounds -- Synthesis
Dartmouth Dissertations

Laser-based oxygen isotopic studies of Acadian metamorphism in eastern Vermont.
Metamorphism (Geology) -- Vermont. Garnet -- Vermont. Laser spectroscopy.
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
Dartmouth Dissertations

Optical properties of some amorphous and crystalline Al Cu alloys.
Aluminum-copper alloys -- Optical properties. Optical films. Alloys -- Analysis.
Dartmouth Dissertations

Spectroscopic and magnetic studies of the nickel metalloenzyme urease.
Urease. Urease -- Magnetic properties. Urea. Hydrolysis.
Dartmouth Dissertations

The interplay between BCL2 family members in response to pharmacologically induced apoptosis
Apoptosis.; Cancer cells -- Growth -- Regulation. ; Cellular signal transduction. ; Apoptosis Regulatory Proteins -- pharmacology. ; Proto-Oncogene Proteins c-bcl-2 -- pharmacology. ; bcl2-Associated Death Protein -- pharmacology. ; Vinblastine --...
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Anticipated emotion in health decision making : an extension of the prototype-willingness model
Health behavior -- Decision making. ; Emotions.
Dartmouth Dissertations

Some applications of group theory to enumerative combinatorial analysis.
Combinatorial analysis. ; Group theory.
Dartmouth Dissertations

Intramolecular general base catalysis of proton abstraction alpha to carbonyl groups.
Carbonyl compounds. ; Chemical kinetics.
Dartmouth Dissertations

Synthesis and kinetic studies of a .delta.4-3-ketosteroid isomerase model.
Isomerases. Enzymes. ; Steroids.
Dartmouth Dissertations

A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations

Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

In vitro reconstitution of exocytosis from sea urchin egg plasma membrane and isolated secretory vesicles.
Sea urchins -- Cytology.
Dartmouth Dissertations

Muscle-specific and activity-dependent transcriptional regulation of nicotinic acetylcholine receptor subunit gene.
Acetylcholine -- Receptors -- Genetic aspects. ; Muscles -- Innervation. ; Neuroplasticity.
Dartmouth Dissertations

Electrical impedance tomography for breast imaging.
Electrical impedance tomography -- Equipment and supplies -- Design and construction. ; Breast -- Cancer -- Diagnosis. ; Breast -- Imaging.
Dartmouth Dissertations

Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

Identification of crucial residues involved in the catalysis of acyl-coenzyme A:cholesterol acyltransferase.
Acyltransferases. ; Cholesterol -- Metabolism. ; Catalysis. ; Acyl Coenzyme A. ; Cholesterol Acyltransferase.
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and in early stages of atherogenesis. ACAT has been investigated as a pharmaceutical target, yet its active site(s) remain largely...
Dartmouth Dissertations

Spectroscopic reconstructed near infrared tomographic imaging for breast cancer diagnosis.
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Breast -- Cancer -- Diagnosis. ; Near infrared reflectance spectroscopy. ; Image processing -- Digital techniques.
Near-infrared (NIR) light has the potential to be used as a non-invasive means of diagnostic imaging within the human breast. Due to the diffusive nature of light in tissue, computational model-based methods are required for functional imaging...
Dartmouth Dissertations

Coping in context: a longitudinal analysis of the relationship between emotion and coping in two stressful situations.
Adjustment (Psychology) -- Testing. ; Affect (Psychology) -- Testing. ; Context effects (Psychology). ; Life change events. ; Stress (Psychology).
Dartmouth Dissertations

Structure/function analyses of the murine -globin locus through trageted mutations.
Globin genes -- Expression. Genetic markers. Genetic transcription -- Regulation. Mutation (Biology).
Genes at the mammalian β-globin loci are arranged in the order of their developmental activation. Expression of individual genes at this locus is controlled by gene proximal and distal cis -regulatory elements. This thesis focused on the function...
Dartmouth Dissertations

Development and application of a dual-excitation, digital imaging, fluorescence microscope to investigate parathyroid hormone-stimulated calcium transport in kidney distal tubule cells.
Fluorescence microscopy. ; Calcium -- Physiological transport -- Measurement. ; Renal tubular transport -- Measurement.
Dartmouth Dissertations

The role of dichoptic brightness in binocular vision.
Binocular vision.
Dartmouth Dissertations

The finger cuff.
Blood pressure -- Measurement.
Dartmouth Dissertations

Development of a ruby fluorescence-based surface probe of tribological processes.
Plastics -- Testing. ; Fluorescent probes. ; Temperature measuring instruments. ; Tribology. ; Polytef -- Thermal properties. ; Nylon -- Thermal properties.
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
Dartmouth Dissertations

Studies related to cholesterol biosynthesis: synthesis of haptens, oxysterols, and late stage inhibitors.
Cholesterol -- Synthesis -- Inhibitors. ; Haptens -- Synthesis. ; Oxysterols -- Synthesis.
Dartmouth Dissertations

Splicing thermotolerance in Drosophila melanogaster.
Heat -- Physiological effect. ; Cells -- Effect of temperature on. ; RNA splicing. ; Drosophila melanogaster.
Dartmouth Dissertations

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