Dartmouth Digital Library Program

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Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Security-policy analysis with eXtended unix tools / by Gabriel A. Weaver.
During our fieldwork with real-world organizations---including those in Public Key Infrastructure (PKI), network configuration management, and the electrical power grid---we repeatedly noticed that security policies and related security artifacts...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Tectonics of the Pacific margin of Northern Central America
Geology, Structural.; Geology -- Central America. ; Plate tectonics -- Pacific Coast (Central America)
Dartmouth Dissertations

Delayed visual feedback and visual-motor control.
Feedback (Psychology); Visual evoked response. Motor ability.
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Intrinsic photoconductivity in molecular crystals,
Crystals -- Electric properties.; Photoconductivity.
Dartmouth Dissertations

Synthetic studies on sarpagine alkaloids.
Alkaloids. Organic compounds -- Synthesis.
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Analysis of zooplankton dynamics: case studies of temporal succession controlled by the predator, Asplancha, and of diel cycles in Keratella.
Freshwater zooplankton. Predation (Biology).
Dartmouth Dissertations

Group 6B metal complexes of three and four membered organic rings.
Organometallic compounds. Transition metal compounds.
Dartmouth Dissertations

A multivariate analysis of self-selection and change due to college experience.
College students -- Psychology. College environment.
Dartmouth Dissertations

Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

Forest structure and atmospheric interactions : predictive models for subalpine balsam fir forest
Forest hydrology -- Mathematical models; Forest Meteorology -- Mathematical models; Balsam fir
Dartmouth Dissertations

Capillary flow of superfluid helium at 0.45°K.
Superfluidity. Liquid helium.
Dartmouth Dissertations

Excitatory and inhibitory properties of human facial expressions of emotion.
Facial expression. Emotions.
Dartmouth Dissertations

A psychophysical investigation of cortical cell receptive field organization in the human visual system.
Visual perception. Visual discrimination.
Dartmouth Dissertations

Quantitative study of perceptual vector analysis.
Vector analysis. Motion perception (Vision)
Dartmouth Dissertations

The effect of microstructure on firn gas transport / by Kaitlin M. Keegan
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Dartmouth Dissertations

Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Dartmouth Dissertations

Group-aware stream filtering.
Streaming technology (Telecommunications). Computer networks -- Monitoring. Multicasting (Computer networks). Electronic data processing -- Distributed processing.
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
Dartmouth Dissertations

Microbial mediation of plant-pollinator interactions / by Robert N. Schaeffer II.
Floral nectar of many plant species is prone to colonization by microorganisms. Their presence and metabolism have the potential to modify a suite of traits important for pollinator attraction, including nectar quality and scent. However, studies...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Modflows : methods for studying and managing mesh editing workflows / by Jonathan D. Denning.
At the heart of computer games and computer generated films lies 3D content creation. A student wanting to learn how to create and edit 3D meshes can quickly find thousands of videos explaining the workflow process. These videos are a popular...
Dartmouth Dissertations

In vivo degradation in modern orthopaedic UHMWPE bearings and structural characterization of a novel alternative UHMWPE material / by Steven D. Reinitz.
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Dartmouth Dissertations

Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
Dartmouth Dissertations

The scaling of forced reconnection in two and three dimensions.
Magnetic reconnection -- Mathematical models. Plasma (Ionized gases). Magnetohydrodynamics -- Mathematical models. Scaling laws (Statistical physics). Forcing (Model theory).
This thesis presents two-fluid simulations of forced magnetic reconnection with finite electron inertia in two and three dimensional periodic systems. Reconnection in the system is driven by a spatially localized forcing function, added to the ion...
Dartmouth Dissertations

Nerve growth factor and the septohippocampal system / by Lan Guo.
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Quantifying optical tomography methods for biomolecular sensing / by Jennifer-Lynn H. Demers.
Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
Dartmouth Dissertations

Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

The cognitive dynamics underlying decision-making : interactions between attention memory and reward in action control / by Kanghoon Jung.
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Evaluating mobility predictors in wireless networks for improving handoff and opportunistic routing.
Wireless communication systems. Computer network protocols.
We evaluate mobility predictors in wireless networks. Handoff prediction in wireless networks has long been considered as a mechanism to improve the quality of service provided to mobile wireless users. Most prior studies, however, were based on...
Dartmouth Dissertations

Role of NA[subscript v]1.1 in septo-hippocampal coordination of theta rhythm and spatial memory : implications for cognitive deficits in Dravet syndrome / by Alex C. Bender
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
Dartmouth Dissertations

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