Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Prion diseases are infectious neurodegenerative disorders characterized by a conformational change of the host-encoded prion protein. The normal nonpathogenic isoform of the prion protein (PrPc) is primarily composed of α-helices and very low...
Ciliata -- Effect of sediments on. ; Ciliata -- Effect of habitat modification on. ; Plankton -- Effect of sediments on. ; Plankton -- Effect of habitat modification on.
Retinoids -- Mechanism of action. ; Post-translational modification. ; Tretinoin -- Therapeutic use. ; Lungs -- Cancer -- Chemoprevention.
The retinoids--natural and synthetic derivatives of vitamin A--are active in cancer therapy and chemoprevention. The signals that underlie retinoid clinical activity are triggered by induction of retinoid target genes. Therefore, a greater...
Serotonergic and non-serotonergic neurons located in the medullary raphe region of the mammalian brainstem are involved in numerous physiological processes. Concerning respiration, neurons in this region have been found to be chemosensitive, i.e.,...
Brain -- Physiology -- Mathematical models.
Brain stem -- Effect of chemicals on.
Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Sodium cotransport systems.
Chemoreceptors.
Respiration -- Regulation -- Genetic aspects.
Brown garden snail -- Respiration.
Carbon dioxide in the body.
Arginine.
Antisense DNA -- Genetics.
Studies of central CO 2 chemosensors are hampered by the complexity of mammalian central nervous systems. Our laboratory developed the pulmonate snail, Helix aspersa , as a relatively simple alternative to mammalian models. A question concerning...
Pseudomonas aeruginosa is an opportunistic pathogen of humans and the leading cause of mortality in patients with the inherited disorder cystic fibrosis (CF). The focus of the studies presented herein was characterization of the regulation and...
Serotonin (5-hydroxytryptamine, 5-HT) in the prefrontal cortex (PFC) plays an important role in cognitive processing and emotional regulation, and altered serotonergic signaling in the cortex is associated with disorders such as schizophrenia,...