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- Characterizing the roles of the central apparatus C1a projection complexes in motility regulation and axoneme assembly
- The eukaryotic cilium (also called flagellum) is a complex, microtubule-based organelle that is found on many different cell types. It produces movement by the precise activation of dyneins that are located along the length and the circumference of...
- Dartmouth Dissertations
- Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
- Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
- Dartmouth Dissertations
- The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
- Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
- Dartmouth Dissertations
- Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
- The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
- Dartmouth Dissertations
- Structural, functional, and biochemical approaches to understanding the role of the C1 microtubule of the flagellar central apparatus.
- Microtubules. Dynein. ; Eukaryotic cells -- Motility.
- The eukaryotic flagellum is a complex organelle that uses the force generated by dynein motors to cause beating motion of the flagellum. The central apparatus of eukaryotic flagella has been implicated in the regulation of dynein-driven motility....
- Dartmouth Dissertations
- The effects of endocrine disruptors on the development of Xenopus embryos.
- Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
- Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
- Dartmouth Dissertations
- Soil biogeochemistry in temperate and arctic ecosystems : human disturbances to a critical carbon pool / by Chelsea L. Petrenko
- I investigated the effects of two contemporary disturbances to soil systems: forest clearing in the northeastern U.S. and climate-driven plant succession in the Arctic. To test the effects of clear-cutting forests on mineral soil carbon (C)...
- Dartmouth Dissertations
- Determinants of the il-1β response to Pseudomonas aeruginosa / by Yash R. Patankar
- IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
- Dartmouth Dissertations
- Evidence based practice in neonatal intensive care: the effect of prophylactic topical emollient ointment therapy and systemic antibiotic administration practices on nosocomial sepsis rates and mortality in extremely low birth weight infants 501 to...
- Neonatal intensive care. ; Evidence-based medicine. ; Nosocomial infections -- Prevention. ; Ointments -- Effectiveness. ; Antibiotics -- Effectiveness.
- Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
- Dartmouth Dissertations
- Asexual diapause in the rotifer Synchaeta pectinata: fitness costs and trade-offs associated with phenotypic variation in a natural population.
- Rotifera -- Vermont -- Reproduction -- Regulation. ; Genotype-environment interaction. ; Diapause. ; Reproduction Asexual.
- Ecological and evolutionary implications of polymorphism and polyphenism in the asexual diapause of the rotifer Synchaeta pectinata from Star Lake, VT, were explored via field, laboratory, and theoretical investigations. S. pectinata is a...
- Dartmouth Dissertations
- Study of the molecular mechanism of the Neurospora circadian clock.
- Neurospora -- Genetics. ; Neurospora -- Effect of light on. ; Circadian rhythms. ; Proteins -- Synthesis -- Effect of light on. ; Genetic regulation.
- The frequency gene and the two proteins it encodes are central components of the Neurospora circadian clock. The frq message and proteins are involved in a negative feedback loop in which FRO represses its own transcript level. Based on this...
- Dartmouth Dissertations
- Analysis of the Drosophila HSP22 gene promoter: characterization of transcriptional regulatory elements.
- Promoters (Genetics). ; Heat shock proteins. ; Sterol hormones. ; Ecdysone. ; Drosophila.
- Dartmouth Dissertations
- Iron acquisition and regulation in Bradyrhizobium japonicum.
- Rhizobium -- Physiology. Rhizobium -- Genetics. Plants -- Effect of iron on.
- Iron is essential in the agriculturally important symbiosis between Bradyrhizobium japonicum and soybean. Studying iron uptake in B. japonicum presents unique challenges in that the organism is found in two very different environments, free living...
- Dartmouth Dissertations
- Functional analysis of cell cycle genes by genome-wide expression data and meta-analysis of RNAi screens.
- Cell cycle -- Regulation. ; Genetic regulation. ; Small interfering RNA. ; Spindle (Cell division). ; Epithelial cells -- Genetic aspects. ; Mammary glands -- Cytology. ; Cell lines. ; Cell Cycle -- genetics. ; Genes cdc. ; RNA Interference. ;...
- Successful traversal of the cell division cycle is paramount for maintaining a cell's genomic integrity and fitness. To ensure the faithful replication and segregation of the genome, cellular components, and cytoplasm, eukaryotes have evolved a...
- Dartmouth Dissertations
- Stimulus control in children under blocking paradigm.
- Learning, Psychology of. ; Stimulus compounding. ; Response consistency.
- Dartmouth Dissertations
- Post-translational modification in retinoid action: a role for UBEIL in cancer therapy and chemoprevention.
- Retinoids -- Mechanism of action. ; Post-translational modification. ; Tretinoin -- Therapeutic use. ; Lungs -- Cancer -- Chemoprevention.
- The retinoids--natural and synthetic derivatives of vitamin A--are active in cancer therapy and chemoprevention. The signals that underlie retinoid clinical activity are triggered by induction of retinoid target genes. Therefore, a greater...
- Dartmouth Dissertations
- Complex integrated order fulfillment technology: a holonic approach.
- Order picking systems -- Automation -- Computer simulation.
- This research ventures into areas beyond traditional control frameworks in its focus. It integrates holonic concepts into a hierarchical control framework of a complex automated order fulfillment technology. Simulation of an actual full-scale order...
- Dartmouth Dissertations
- Regulation of human monocyte CD163 during the innate immune response to infection.
- CD antigens. Immune response -- Regulation. Hemoglobin.
- CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
- Dartmouth Dissertations
- A computational dissection in the evolution of cell growth.
- Genetic regulation. Cells -- Growth -- Regulation. Ribosomes. DNA -- Synthesis. Evolutionary genetics.
- Gene regulation is a principle tool that all organisms utilize to control development, growth, and responses to environmental conditions. Understanding how organisms orchestrate the spatiotemporal regulation of gene expression remains a fundamental...
- Dartmouth Dissertations
- The detection and characterization of epistasis and heterogeneity :a learning classifier system approach
- As the ubiquitous complexity of common disease has become apparent, so has the need for novel tools and strategies that can accommodate complex patterns of association. In particular, the analytic challenges posed by the phenomena known as...
- Dartmouth Dissertations
- Role of Whi3 protein aggregation behavior in cell-cycle regulation and cell polarity / by ChangHwan Lee.
- Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle...
- Dartmouth Dissertations
- ENVS 25, Ecological Agriculture, taught by Sarah S...
- Dartmouth College Photographic Records
- ENVS 25, Ecological Agriculture, taught by Sarah S...
- Dartmouth College Photographic Records
- ENVS 25, Ecological Agriculture, taught by Sarah S...
- Dartmouth College Photographic Records
- Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
- Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
- Dartmouth Dissertations
- Temperature effects on food web interactions : from lakes to landscapes / by Samuel Butler Fey.
- Temperature has powerful effects on all scales of biological organization from biochemical reactions to ecosystem processes. Despite the well-appreciated influence and thorough understanding of the physiological and population consequences of...
- Dartmouth Dissertations
- The RNA binding landscape of the histone stem-loop binding protein / by Lionel (Lee) Brooks 3rd.
- RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
- Dartmouth Dissertations
- Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
- Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
- Dartmouth Dissertations
- SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
- Nuclear membranes. Membrane proteins. Genetic regulation.
- The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
- Dartmouth Dissertations
- Reactor design considerations for the conversion of particulate biomass to ethanol.
- Bioreactors -- Design and construction. Alcohol as fuel. Biomass energy.
- Dartmouth Dissertations
- Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
- Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
- To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
- Dartmouth Dissertations
- Regeneration studies of a single indentifiable motoneuron in the crayfish Procambarus Clarkii.
- Motor neurons. ; Nervous system -- Regeneration. ; Crayfish.
- Dartmouth Dissertations
- Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
- Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
- Dartmouth Dissertations
- Eisosomes organize the plasma membrane of yeast / by Ruth V. Kabeche
- The cortical cytoskeleton mediates a range of cellular activities such as endocytosis, cell motility, and the maintenance of cell rigidity. In yeast cells, prominent cortical structures called eisosomes generate specialized domains termed MCCs to...
- Dartmouth Dissertations
- Thermodynamic studies of copper binding to azurin : development and application of a novel method to determine the reduction potential and reduction thermodynamics of metalloproteins / by Molly L. Croteau
- Cupredoxins, such as stellacyanin, plastocyanin, amicyanin, rusticyanin, and azurin perform electron transfer (ET) reactions with partner protein(s) in the cell. The role of the redox cofactor in these proteins is played by a copper ion, which...
- Dartmouth Dissertations
- Specificity in signaling : bacterial decision-making through the cyclic diguanylate second messenger / by Kurt M. Dahlstrom
- Cyclic diguanylate (c-di-GMP) is a primarily bacterial and nearly universal second messenger used to stimulate a variety of responses from the cell by binding effector proteins. It is created by enzymes called diguanylate cyclases (DGCs) and broken...
- Dartmouth Dissertations
- NPC1-mediated trafficking of intracellular cholesterol.
- Cholesterol -- Physiological transport. Cholesterol -- Genetic aspects. Cholesterol -- Metabolism. Genetic disorders -- Molecular aspects.
- Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
- Dartmouth Dissertations
- The cloning and characterization of genes involved in amino acid metabolism in Neurospora crassa.
- Neurospora crassa -- Genetics. ; Molecular cloning.
- Dartmouth Dissertations
- Evolution in fickle environments: dispersal, specialization, and the problem of heterogeneity.
- Caenorhabditis elegans -- Ecology. ; Ecological heterogeneity. ; Evolution (Biology). ; Adaptation (Biology). ; Nematodes -- Dispersal.
- All ecological theories regarding the distribution and relative abundance of species refer to organisms'' abilities to utilize an environment and (sometimes implicitly) their ability to colonize and re-colonize habitats that change in character or...
- Dartmouth Dissertations
- Northeastern Venezuela''s Jurassic through Eocene passive margin, Hispaniola''s Neogene Cibao Basin, and their histories and causes of evolution.
- Geology -- Venezuela. ; Geology -- Dominican Republic -- Cibao Basin. ; Geology Structural -- Venezuela. ; Geology.
- Dartmouth Dissertations
- CO2 chemoreceptor function in the pulmonate snail.
- Helix (Mollusks) -- Respiration. ; Chemoreceptors. ; Carbonic anhydrase.
- Dartmouth Dissertations
- Light and circadian regulation in Neurospora crassa.
- Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
- Dartmouth Dissertations
- Cellulose hydrolysis and fermentation by Clostridium thermocellum for the production of ethanol.
- Clostridium -- Biotechnology. ; Cellulose. ; Hydrolysis. ; Fermentation. ; Alcohol -- Synthesis.
- Dartmouth Dissertations
- Control of developmental timing in Caenorhabditis elegans by lin-14.
- Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
- The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
- Dartmouth Dissertations
- Molecular characterization of human deoxyribonuclease II[alpha]: structural determinants of activity and therapeutic implications.
- Deoxyribonucleases. ; Deoxyribonucleases -- Therapeutic use. ; Endonucleases -- Genetic aspects. ; Structure-activity relationships (Biochemistry). ; Pichia pastoris -- Cytogenetics. ; Cystic fibrosis -- Chemotherapy.
- Dartmouth Dissertations
- Circadian regulation of gene expression in Arabidopsis thaliana.
- Arabidopsis thaliana. ; Circadian rhythms. ; Genetic regulation.
- Dartmouth Dissertations
- Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
- Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
- The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
- Dartmouth Dissertations
- Homing, density and population dynamics in the adult newt, notopthalmus viridescens rafinesque.
- Newts.
- Dartmouth Dissertations
- Functional analysis of the Runx1 C-terminal sequences.
- Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
- RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
- Dartmouth Dissertations
- Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
- Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
- Dartmouth Dissertations

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