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- Hospital: March 1999; Dartmouth Hitchcock Medical ...
- Dartmouth College Photographic Records
- The impact of prenatal and postnatal home visiting on utilization of care.
- Home care services -- Utilization -- New Hampshire. Home care services -- New Hampshire -- Evaluation. Maternal health services -- Utilization -- New Hampshire. Infant health services -- Utilization -- New Hampshire. Prenatal care -- Utilization --...
- Research objective . Research suggests that home visiting services can have a significant impact on pregnancy outcomes, child health and development, parenting and maternal life course. The effect of home visiting on utilization of health services...
- Dartmouth Dissertations
- Eunice Y. Chen, Pediatric Otolaryngology, DHMC (Da...
- Dartmouth College Photographic Records
- Medicine: June 1992; Dartmouth Hitchcock Medical C...
- Dartmouth College Photographic Records
- Medicine: June 1992; Dartmouth Hitchcock Medical C...
- Dartmouth College Photographic Records
- Student Life: October 1992; Dartmouth Hitchcock Me...
- Dartmouth College Photographic Records
- Hospital: March 1999; Dartmouth Hitchcock Medical ...
- Dartmouth College Photographic Records
- Medicine: March 1989; Hitchcock Hospital; Dr. Rock...
- Dartmouth College Photographic Records
- Gingerbread House at Dartmouth Hitchcock Medical ...
- Dartmouth College Photographic Records
- Medicine: February 1991; Mary Hitchcock Memorial H...
- Dartmouth College Photographic Records
- Tuck Volunteers at DHMC; MHMH; Two Tuck students d...
- Dartmouth College Photographic Records
- Individuals L; Associate Dean, Tuck School, Dennis...
- Drawer 16; Individuals L
- Dartmouth College Photographic Records
- E. E. Just Symposium: posted on Flickr, Andrea Hay...
- Dartmouth College Photographic Records
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- Evidence based practice in neonatal intensive care: the effect of prophylactic topical emollient ointment therapy and systemic antibiotic administration practices on nosocomial sepsis rates and mortality in extremely low birth weight infants 501 to...
- Neonatal intensive care. ; Evidence-based medicine. ; Nosocomial infections -- Prevention. ; Ointments -- Effectiveness. ; Antibiotics -- Effectiveness.
- Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
- Dartmouth Dissertations
- Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
- Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
- Dartmouth Dissertations
- Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
- Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
- The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
- Dartmouth Dissertations
- Inter-specialty differences in outcomes associated with adult primary care physician supply.
- Primary care (Medicine) -- United States -- Evaluation. Medicine -- Specialties and specialists. Physicians -- Supply and demand -- United States.
- Background: Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
- Dartmouth Dissertations
- The effect of epileptiform activity and seizures during development on the prefrontal cortex and cognition / by Amanda Erin Hernan.
- Epilepsy is the most common neurological disorder in children, with an incidence of 100 per 100,000 children per year. Recurrent seizures during this period in life are often distressing to the individual and the family, but arguably the most...
- Dartmouth Dissertations
- Portrait: Kerrigan: Levin: October 1996; Physician...
- Dartmouth College Photographic Records
- Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
- Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
- Dartmouth Dissertations
- Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
- As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
- Dartmouth Dissertations
- Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
- In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
- Dartmouth Dissertations
- Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
- Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
- Dartmouth Dissertations
- MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
- The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
- Dartmouth Dissertations
- Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
- Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
- Dartmouth Dissertations
- Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
- It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
- Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
- Dartmouth Dissertations
- An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
- Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
- Dartmouth Dissertations
- Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
- Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
- Dartmouth Dissertations
- Cholesterol metabolism and human diseases
- Cholesterol -- Metabolism. ; ATP-binding cassette transporters. ; Niemann-Pick diseases -- Genetic aspects. ; Acyltransferases. ; Pregnenolone. ; Sterols. ; Acetyl-CoA C-Acetyltransferase.
- Dartmouth Dissertations
- The importance of dosage of core binding factors α and ß in hematopoietic development.
- Hematopoiesis -- Regulation. ; Transcription factors.
- Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
- Dartmouth Dissertations
- Assessing communication skills in medical education: development of the patient video interview.
- Medicine -- Study and teaching -- Audio-visual aids. ; Communication -- Audio-visual aids. ; Medical history taking. ; Physician and patient. ; Psychometrics.
- The Patient Video Interview (PVI) is an instrument designed to assess communication skills in medical education that overcomes some of the drawbacks of other assessment methods. Three studies were conducted to: (a) determine a measurement system...
- Dartmouth Dissertations
- Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
- Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
- Dartmouth Dissertations
- High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
- Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
- Dartmouth Dissertations
- Characterizing the impact of single nucleotide variation in breast cancer / by Kinjal Desai
- Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
- Dartmouth Dissertations
- Serotonin signaling in the nucleus tractus solitarius modulates the larybgeal chemoreflex : implications for sudden infant death syndrome / by William T. Donnelly
- Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
- Dartmouth Dissertations
- Relating behavioral control and brain development : insights from adolescence / by Heidi Catherine Meyer
- Across mammalian species, adolescence is characterized by a unique combination of cognitive, behavioral and neurobiological changes. Behavioral tendencies observed during this period promote a variety of flexible interactions with the surrounding...
- Dartmouth Dissertations
- Characterization of cancer risk and response to immunotherapy through pathway-based genomic analyses / by David C. Qian
- For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
- Dartmouth Dissertations
- Subtypes of developmental prosopagnosia : behavioral and neural evidence / by Hua Yang
- Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
- Dartmouth Dissertations
- On the origins of cancer cell identity : epigenetic deregulation of cellular states / by Kevin Johnson
- The identification of molecular alterations present in cancer is critical to better understand carcinogenesis as well as the clinical trajectories of patients with malignant tumors. Early detection and application of appropriate treatment...
- Dartmouth Dissertations
- Discovering MII1 regulated pathways in hematopoietic stem cells.
- Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
- Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
- Dartmouth Dissertations
- NPC1-mediated trafficking of intracellular cholesterol.
- Cholesterol -- Physiological transport. Cholesterol -- Genetic aspects. Cholesterol -- Metabolism. Genetic disorders -- Molecular aspects.
- Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
- Dartmouth Dissertations
- Sensing eye position.
- Saccadic eye movements. ; Eye -- Movements. ; Visual perception -- Physiological aspects. ; Senses and sensation.
- The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
- Dartmouth Dissertations
- Spatial feature extraction algorithms.
- Image processing -- Digital techniques. Spatial systems -- Data processing. Pattern recognition systems. Computer algorithms.
- Dartmouth Dissertations
- Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
- Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
- Dartmouth Dissertations
- Individual differences in callosal organization: relationship to interhemispheric communication and hemispheric asymmetries.
- Corpus callosum -- Physiology. Cerebral hemispheres. Laterality. Sensorimotor integration. Brain -- Localization of functions.
- The overarching goal of the dissertation was to further understanding of the relationship between callosal organization, functional lateralization, and interhemispheric communication in the healthy, young adult brain. Three converging methodologies...
- Dartmouth Dissertations
- Patient outcomes and decision making in the treatment of hypoplastic left heart syndrome.
- Congenital heart disease in children -- Surgery -- Evaluation. ; Heart -- Abnormalities -- Surgery -- Evaluation. ; Outcome assessment (Medical care).
- Hypoplastic left heart syndrome (HLHS) is a heart malformation that requires surgical intervention for survival. Without surgery, 95% of neonates with HLHS die in the first month of life. Two surgical approaches are available, a series of...
- Dartmouth Dissertations
- Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
- Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
- This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
- Dartmouth Dissertations

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