Dartmouth Digital Library Program

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Temporal selective attention in letter perception.
Attention -- Testing. ; Selectivity (Psychology) -- Testing. ; Visual perception -- Testing. ; Human information processing -- Testing.
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Regulation of B lymphocyte proliferation and differentiation through CD40.
B cells. CD antigens. Immune response -- Regulation.
Dartmouth Dissertations

Treatment planning software for the Dartmouth IMAAH system
Cancer -- Radiotherapy -- Computer programs; Microwave antennas -- Physiological effect -- Computer programs
Dartmouth Dissertations

Low temperature properties of germanium, silicon and carbon with application to bolometry
Germanium. ; Silicon. ; Carbon.
Dartmouth Dissertations

Regeneration studies of a single indentifiable motoneuron in the crayfish Procambarus Clarkii.
Motor neurons. ; Nervous system -- Regeneration. ; Crayfish.
Dartmouth Dissertations

Primate origins through the lens of functional and degenerate cone opsins / by Gillian L. Moritz
A nocturnal activity pattern is central to almost all hypotheses on the adaptive origins of primates but this view has been challenged recently on the basis of variation in the cone opsin genes of nocturnal primates. The diversity among primates in...
Dartmouth Dissertations

Rewards and self-regulation in the resting brain / by Jeremy Ford Huckins
The ability to resist highly tempting reward impulses is a struggle that all humans face on a daily basis, one that gives rise to many societal problems such as obesity and drug addiction. This form of self-regulation involves a critical balance...
Dartmouth Dissertations

Functional heterogeneity and helper roles of CD4+T cells in antiviral immunity / by Zhuting Hu
CD4+ T cells are critical for the control of virus infections, memory cell formation and immune surveillance. Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus are two γ-herpesviruses identified in humans and are strongly associated...
Dartmouth Dissertations

Electrical impedance acquisition system for surgical margin assessment during robot-assisted laparoscopic prostatectomy / by Shadab Khan
Prostate cancer (PCa) recurrences are often predicted by assessing the status of surgical margins (SM) – positive surgical margins (PSM) increase the chances of biochemical recurrence by 2-4 times which may lead to PCa recurrence. At present,...
Dartmouth Dissertations

A benzonorbornyl model system for the study of carbocation-[pi] interactions.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dartmouth Dissertations

Evidence for two spindle fiber components.
Chromosomes. ; Crane flies.
Dartmouth Dissertations

Investigation of the molecular basis of directed particle movement in the squid giant axon.
Axonal transport. ; Molecular dynamics. ; Squids.
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

The mitotic protein p62 is localized to the nucleolus during interphase.
Nucleoproteins. ; Mitosis. ; Nucleolus. ; Molecular biology.
Mitotic apparatuses from sea urchin embryos contain a protein (p62), previously shown to be required for mitotic progression. This protein localizes to the mitotic apparatus during cell division in urchin embryos and mammalian tissue culture cells....
Dartmouth Dissertations

Modeling of shocks in young and old supernova remnants.
Supernova remnants. Shock waves -- Mathematical models. Interstellar matter.
We present results from a modeling effort of simple shock phenomena in the Cygnus Loop and Cassiopeia A. Using multi-epoch MDM observations of a small, isolated cloud in the southwest region of the Cygnus Loop, we measure the velocity of the...
Dartmouth Dissertations

Hyperthermia and low dose rate irradiation.
Radioisotope brachytherapy. ; Cancer -- Radiotherapy.
Dartmouth Dissertations

The role of retinoic acid on CD4+ T cell biology.
T cells.; Tretinoin -- Physiological effect. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Investigation of the requirements for transitional endoplasmic reticulum (tER) site structure and function in Saccharomyces cerevisiae.
Endoplasmic reticulum.; Membrane proteins -- Physiological transport. ; Coated vesicles. ; Golgi apparatus. ; Saccharomyces cerevisiae -- Molecular aspects. ; Phospholipids -- Physiological effect. ; Saccharomyces cerevisiae Proteins. ; COP-Coated...
Eukaryotic cells contain distinct membrane-bound organelles that house sets of specialized metabolic reactions. The network of controlled communications between organelles is known as the secretory pathway. Transport of proteins and lipids between...
Dartmouth Dissertations

The effect of stress state on the brittle compressive failure of columnar ice.
Ice mechanics. ; Compressibility. ; Strains and stresses. ; Brittleness. ; Fracture mechanics.
Dartmouth Dissertations

Designing treatment individualization in photodynamic therapy to compensate for pharmacokinetic variability.
Photochemotherapy. Photosensitizing compounds -- Therapeutic use. Pharmacokinetics. Drugs -- Physiological effect.
The main theme of this thesis is to investigate the origins of photosensitizer pharmacokinetic variability, how this pharmacokinetic variation affects photodynamic therapy (PDT), and to search for innovative strategies to reduce the...
Dartmouth Dissertations

The role of Protein kinase C in FcαR and BCR trafficking to MHC class II-containing compartments and antigen presentation.
Protein kinase C. Antigen presenting cells. Antigens -- Receptors. T cells -- Receptors. Major histocompatibility complex -- Genetic aspects. CD4-Positive T-Lymphocytes -- immunology. Histocompatibility Antigens Class II -- immunology. Receptors
Activation of CD4 T cells to exogenous antigens requires the formation and surface display of antigen-derived peptide-MHC class II complexes by antigen presentation cells. Acquisition of peptide by MHC class II is much studied, but the rules and...
Dartmouth Dissertations

Collaborative automated trust negotiation.
Computer networks -- Security measures. Computers -- Access control.
Automated trust negotiation is a new approach to access control and authentication for the open systems such as the Internet, where sensitive interactions sometimes occur among entities with no prior knowledge of each other. Trust negotiation...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

A computational study of radio relics in galaxy cluster mergers / by Dane Patrick Owen.
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Crevasse detection in ice sheets using ground penetrating radar and machine learning / by Rebecca M. Williams.
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Forest structure and atmospheric interactions : predictive models for subalpine balsam fir forest
Forest hydrology -- Mathematical models; Forest Meteorology -- Mathematical models; Balsam fir
Dartmouth Dissertations

A psychophysical investigation of cortical cell receptive field organization in the human visual system.
Visual perception. Visual discrimination.
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Quantifying optical tomography methods for biomolecular sensing / by Jennifer-Lynn H. Demers.
Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

Role of NA[subscript v]1.1 in septo-hippocampal coordination of theta rhythm and spatial memory : implications for cognitive deficits in Dravet syndrome / by Alex C. Bender
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

Excitation transfer in strain-induced quantum wires and dots.
Semiconductors -- Optical properties. Quantum wells. Quantum electronics.
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
Dartmouth Dissertations

ID4 promotes the growth of glioblastoma multiforme by mediating MGP-enhanced angiogenesis.
Glioblastoma multiforme. DNA-binding proteins. Transcription factors. Extracellular matrix proteins. Neovascularization.
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Dartmouth Dissertations

Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
Dartmouth Dissertations

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