Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
The thermodynamic properties of pure polymers and polymer mixtures have been investigated using the so-called Born-Green-Yvon (BGY) lattice theory. Previous results applied pure component pressure-volume-temperature ( PVT ) data in order to...
Nanoparticles -- Magnetic properties.;""Harmonics (Electric waves)"";""Biosensors."";""Spectrum analysis."";""Brownian motion processes.""
Magnetic nanoparticles have an increasing role in the clinical and pharmaceutical realms where their physical properties can be exploited for imaging, biological and functional sensing, control of cellular processes, therapeutics, and an array of...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Recent technological advances have fostered the emergence of Wireless Sensor Networks (WSNs), which consist of tiny, wireless, battery-powered nodes that are expected to revolutionize the ways in which we understand and construct complex physical...
All ecological theories regarding the distribution and relative abundance of species refer to organisms'' abilities to utilize an environment and (sometimes implicitly) their ability to colonize and re-colonize habitats that change in character or...
Flexible fiber scopes are widely used in industry and medicine. Typical scopes are made using conventional optical components and order-packed flexible image bundles. The optical performance of a flexible scope is largely determined by that of the...
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
The thermophilic anaerobic bacterium Clostridium thermocellum has attracted researchers attention because of its potential industrial application and high cellulose hydrolysis rates. This study focuses on the physiological fundamentals of C....
Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Southern pine beetle -- Ecology. Mutualism (Biology). Commensalism.
A challenge for ecologists is to identify and understand the mechanisms that produce population behaviors in nature. This is particularly difficult in complex communities that comprise of tightly linked multivoltine organisms that are...
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
A variety of forensic methods have been developed to identify falsified photos, each unified by the ability to estimate and detect properties of a photo that are perturbed by forgery. There exist, however, many photos in which the required...