Dartmouth Digital Library Program

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Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Coordination chemistry and DNA-binding studies of a non-classical zinc finger motif.
Coordination compounds. ; Zinc-finger proteins. ; DNA-binding proteins. ; DNA-protein interactions.
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

Analyses of SOS-type DNA repair processes in mammalian cells
DNA repair. ; Mammals -- Cytology. ; Mutagenesis
Dartmouth Dissertations

Isolation and characterization of the nuclear gene and gene product of COX12, the gene encoding subunit VIb of cytochrome c oxidase of Saccharomyces cerevisiae.
Cytochrome oxidase -- Genetic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Molecular microbiology.
Dartmouth Dissertations

Multiple pathways for macromolecular transport through the nuclear pore complex in Saccharomyces cerevisiae.
Saccharomyces cerevisiae -- Genetics. ; Messenger RNA -- Genetic aspects. ; Proteins -- Synthesis. ; Heat shock proteins.
Dartmouth Dissertations

Conformationally restricted bis(9-aminoacridine)s : a chemical and biological study
Acridine.
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Dartmouth Dissertations

Expression and recovery of recombinant proteins in a novel high cell density prokaryotic system based on Ralstonia eutropha.
Ralstonia -- Biotechnology. Microbial biotechnology. Industrial microbiology. Recombinant proteins -- Synthesis. Recombinant Proteins -- Biosynthesis.
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Dartmouth Dissertations

Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
RNA -- Metabolism. ; Herpes simplex virus.
Dartmouth Dissertations

Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Characterization of ccg-1, a clock-controlled gene of Neurospora crassa.
Biological rhythms. ; Genetic regulation. ; Neurospora crassa.
Dartmouth Dissertations

The effects of chemical carcinogens on hormone-inducible gene expression in chick embryo liver in vivo.
DNA damage -- Research. ; Gene expression -- Research. ; Chickens -- Embryos -- Effect of metals on. ; Chromium -- Research.
Dartmouth Dissertations

Regulation of chromosome segregation by ORD and dRING during Drosophila meiosis.
Meiosis. Drosophila melanogaster -- Cytogenetics. Sister chromatid exchange. Chromosome Segregation.
Accurate segregation of meiotic chromosomes requires that sister-chromatids remain physically associated from the time of their synthesis during S phase until they segregate toward opposite poles at anaphase II. In Drosophila melanogaster meiosis,...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

Reactive intermediates in chromium carcinogenesis.
Chromium -- Toxicology. Carcinogenesis.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Synthetic studies of ellipticine alkaloids and structurally related compounds.
Alkaloids -- Synthesis.
Dartmouth Dissertations

The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
Mitochondria. Enzymes. ; Rats.
Dartmouth Dissertations

The role of mitochondria in chromium carcinogenesis.
Chromium. Carcinogens. ; Mitochondria.
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Biological significance of VIVID photocycle length and the control of gene expression by the Neurospora clock / by Arko Dasgupta
Sensing light from the environment using photoreceptors is of great adaptive significance to eukaryotes. A prominent feature of the photochemistry of these receptors is the photocycle length, the time taken to decay from the initial signaling light...
Dartmouth Dissertations

Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Dartmouth Dissertations

Isolation of interleukin-2-induced immediate-early genes.
Interleukin-2.
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

An analysis of an ecdysterone response element from the Drosophila hsp27 gene.
Ecdysone. ; Gene expression. ; Drosophila -- Genetics. ; Heat shock proteins.
Dartmouth Dissertations

Development and application of a genetically-structured simulation for bacteriophage T7.
Viral genetics -- Mathematical models. ; Bacteriophages -- Growth -- Computer simulation. ; Recombinant viruses. ; Bacteriophage T7.
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

Iron acquisition in Bradyrhizobium japonicum.
Rhizobium -- Physiology. ; Plants -- Effect of iron on.
Dartmouth Dissertations

The biochemical basis of Th-dependent B cell activation.
B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
Dartmouth Dissertations

Positive and negative factors involved in transactivation of RNA polymerase II elongation by HIV-1 Tat.
RNA polymerases. HIV (Viruses). Genetic transcription -- Regulation. HIV-1 -- genetics. Gene Products
The HIV-1 Tat protein is a widely studied paradigm for regulation of elongation of RNAP II. In the absence of Tat, the majority of polymerases that initiate transcription from the HIV promoter appear to pause or dissociate from the DNA rapidly as a...
Dartmouth Dissertations

The effect of iron, oxygen, and heme on the expression of Bradyrhizobium japonicum hemA gene.
Rhizobium -- Genetics. ; Heme -- Genetics. ; Bacterial genetics. ; Genetic regulation.
Dartmouth Dissertations

Iron acquisition and regulation in Bradyrhizobium japonicum.
Rhizobium -- Physiology. Rhizobium -- Genetics. Plants -- Effect of iron on.
Iron is essential in the agriculturally important symbiosis between Bradyrhizobium japonicum and soybean. Studying iron uptake in B. japonicum presents unique challenges in that the organism is found in two very different environments, free living...
Dartmouth Dissertations

The roles of glutathione and ascorbate in chromium (VI)-induced carcinogenesis in vivo.
Chromium -- Toxicity testing. ; Glutathione. ; Vitamin C -- Physiological effect. ; Carcinogenesis. ; DNA damage.
Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...
Dartmouth Dissertations

Structure-function relations of cell membrane Ca efflux proteins.
Calcium-binding proteins. ; Renal tubular transport. ; Calcium -- Metabolism -- Regulation.
Dartmouth Dissertations

Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Isolation and characterization of essential genes of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Messenger RNA. ; Saccharomyces cerevisiae. ; Cytoplasm.
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

The molecular basis for the carcinogenicity of nickel.
Nickel. ; Nickel compounds. ; Carcinogens.
Dartmouth Dissertations

The role of p38 MAP kinase in the regulation of mRNA stability.
Messenger RNA -- Metabolism. ; Mitogens. ; Thalidomide. ; Glucose -- Physiological transport. ; Mitogen-Activated Protein Kinases. ; MAP Kinase Signaling System. ; Protein processings Post-transcriptional. ; Hippel-Lindau Disease.
We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

Interrelationships between carbohydrate, uridine nucleotide and protein metabolism and effects of cortisol on these interrelationships.
Carbohydrates -- Metabolism. ; Proteins -- Metabolism. ; Hydrocortisone.
Dartmouth Dissertations

The expression and activity of TP63 in the mammary epithelial regenerative hierarchy.
Tumor proteins. ; p53 antioncogene. ; Epithelial cells. ; Mammary glands -- Cytology. ; Stem cells. ; Regeneration (Biology). ; Genetic transcription -- Regulation. ; Cellular signal transduction.
Dartmouth Dissertations

IL-1 regulation of collagenase-3 (MMP-13) gene expression in chondrocytic cells.
Interleukin-1. ; Extracellular matrix proteins -- Metabolism. ; Cartilage cells -- Metabolism. ; Metalloproteinases -- Genetic aspects. ; Collagenases -- Genetic aspects. ; Genetic transcription -- Regulation. ; Chondrocytes
The matrix metalloproteinases (MMPs) are family of enzymes with a common domain structure that degrade extracellular matrix proteins; these enzymes are overexpressed in numerous diseases including cancer and arthritis. Collagenase-1, 2, 3 (MMP-1,...
Dartmouth Dissertations

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