Dartmouth Digital Library Program

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The macromolecular assembly of NuMA.
Nucleoproteins. ; Macromolecules. ; Cell organelles -- Formation. ; Mitosis. ; Phosphorylation.
Dartmouth Dissertations

A lead of open water prevented us from joining the...
A lead of open water prevented us from joining the party (typed label: A typical view of the pack far from land. It shows rough ice where no landings can be made, level landing ice for skis, and in the distance open water for flying-boat landings,...
Stefansson Collection of Arctic Photographs - Photographic Prints

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

The relationship between the apomorphine and the narcotic receptors of the emetic chemoreceptor trigger zone of the cat.
Emetics. ; Apomorphine. ; Morphine.
Dartmouth Dissertations

Neurohypophysial function during acute stimulation in rats: role of vasopressin in regulation of blood pressure and oxytocin release.
Blood pressure. ; Vasopressin. ; Neurophysiology. ; Rats as laboratory animals.
Dartmouth Dissertations

Bcl-2 family proteins and the regulation of apoptosis.
Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

Regeneration of neuromuscular connections from allotransplanted ganglia in the crayfish.
Ganglia, Sensory -- Transplantation. ; Central nervous system -- Regeneration. ; Procambarus clarkii -- Nervous system. ; Neurons -- Innervation. ; Synapses.
Dartmouth Dissertations

Tracing the retention and redistribution of lead and other atmospheric fallout in soils.
Soils -- Lead content -- New Hampshire. ; Soils -- Lead content -- Vermont. ; Lead -- Environmental aspects -- New Hampshire. ; Lead -- Environmental aspects -- Vermont. ; Atmospheric deposition -- Environmental aspects -- New Hampshire. ; ...
A basic understanding of how atmospherically-derived elements behave in soils is of concern in contaminant transport, nutrient cycling, and carbon sequestration studies. Here, I use stable and radioactive tracers to evaluate the fate of...
Dartmouth Dissertations

Data-based predictive control.
Predictive control. Input-output analysis.
Dartmouth Dissertations

Synthetic studies of Munchnone reactivity and applications and the total synthesis of cyclopenta[B]indole natural products / by Justin M. Lopchuk.
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Simultaneous saccharification and co-fermentation of paper sludge.
Cellulose -- Biodegradation. Zymomonas mobilis -- Biotechnology. Saccharomyces cerevisiae -- Biotechnology. Fermentation. Hydrolysis. Biomass conversion -- Mathematical models.
Production of fuel ethanol from cellulosic materials is a potentially attractive way to meet sustainability, energy security, and environmental goals. However, the high cost of processing using current technology has thus far prevented...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Delayed visual feedback and visual-motor control.
Feedback (Psychology); Visual evoked response. Motor ability.
Dartmouth Dissertations

Behavior therapy for phobias (extinction of avoidance) in rats.
Extinction (Psychology); Avoidance (Psychology); Behavior therapy.
Dartmouth Dissertations

Intrinsic photoconductivity in molecular crystals,
Crystals -- Electric properties.; Photoconductivity.
Dartmouth Dissertations

The representation of size information in semantic memory.
Memory. Size perception. Semantics.
Dartmouth Dissertations

Synthetic studies on sarpagine alkaloids.
Alkaloids. Organic compounds -- Synthesis.
Dartmouth Dissertations

Energy gaps and infrared spectra by electron tunneling.
Tunneling (Physics); Energy levels (Quantum mechanics).
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Examining auroral downward current region processes using ground based data.
Auroras -- Alaska -- Observations. Magnetospheric currents.
This thesis presents data from ground camera observations of the aurora conducted from Alaska during the winters of 2005 through 2007. In conjunction with these camera observations, conjugate radar observations of the auroral ionosphere were...
Dartmouth Dissertations

The synthesis and chemistry of novel cyclic perfluoromethyl-substituted molecules.
Fluorine compounds.
Dartmouth Dissertations

Color centers and thermoluminescence in LiF.
Thermoluminescence. Lithium fluoride.
Dartmouth Dissertations

A prediction of the interaction of a normal shock with a separating, turbulent boundary layer.
Shock waves. Turbulent boundary layer.
Dartmouth Dissertations

The problems of perception and regulation in the relationship between activities and mood.
Mood (Psychology)
Dartmouth Dissertations

Drift waves in a nonuniformly rotating plasma column.
Drift waves. Rotating plasmas.
Dartmouth Dissertations

Performance decrement following insolvable problems: learned helplessness or failure anxiety?
Failure (Psychology);Helplessness (Psychology)
Dartmouth Dissertations

Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Determining anthropogenic and natural controls on the global mercury cycle using lake sediment and ice cores ; by Samuel Adams Beal Jr.
While anthropogenic emissions of the toxic element mercury (Hg) to the atmosphere are currently rising, major uncertainties remain in determining the relative impacts of anthropogenic activity and natural processes on the global Hg cycle. In this...
Dartmouth Dissertations

Group-aware stream filtering.
Streaming technology (Telecommunications). Computer networks -- Monitoring. Multicasting (Computer networks). Electronic data processing -- Distributed processing.
Recent years have witnessed a new class of monitoring applications that need to continuously collect information from remote data sources. Those data sources, such as web click-streams, stock quotes, and sensor data, are often characterized as...
Dartmouth Dissertations

Microbial mediation of plant-pollinator interactions / by Robert N. Schaeffer II.
Floral nectar of many plant species is prone to colonization by microorganisms. Their presence and metabolism have the potential to modify a suite of traits important for pollinator attraction, including nectar quality and scent. However, studies...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Towards the experimental verification of macroscopic phenomena in quantum electrodynamics.
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

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