Dartmouth Digital Library Program

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High-speed MRI-guided near-infrared tomography system to monitor breast hemodynamics in vivo ;
Near infrared spectroscopy -- Instruments -- Design and construction.;""Magnetic resonance imaging -- Instruments -- Design and construction."";""Breast -- Cancer -- Imaging."";""Breast -- Magnetic resonance imaging."";""Breast -- Cancer --...
Dartmouth Dissertations

Glucocorticoids affect the action of gamma interferon on human monocytes.
Glucocorticoids. ; Interferon. ; Monocytes. ; Immunity.
Dartmouth Dissertations

Magnetic susceptibility imaging of magnetic nanoparticles / by Bradley W. Ficko.
Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
Dartmouth Dissertations

Later stage brain deformation compensation in image-guided neurosurgery
In image-guided neurosurgery, preoperative magnetic resonance images (pMR) are typically used intraoperatively for neuronavigation. The accuracy of image guidance using preoperative images can be significantly compromised by intraoperative brain...
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Reaggregation of sea urchin embryonic cells.
Sea urchins -- Embryos. ; Embryology Experimental. ; Cell aggregation.
Dartmouth Dissertations

The effects of endocrine disruptors on the development of Xenopus embryos.
Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
Dartmouth Dissertations

Carbon dioxide: hydrogen ion sensory mechanism of the carotid body.
Carbon dioxide -- Physiological effect. ; Carotid body.
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Identifying airway obstructions from photoplethysmography (PPG).
Plethysmography. ; Airway (Medicine) -- Obstructions. ; Respiration -- Mathematical models. ; Respiration -- Data processing. ; Airway Obstruction -- diagnosis.
Emergency medical response requires timely and efficient assessment and treatment of casualties. Mass casualty situations, in particular, strain the resources of emergency responders, prompting the need for a well-organized, effective, automated...
Dartmouth Dissertations

Nuclear receptor corepression, negative feedback and transcription-based oscillation: Evidence for a novel form of nuclear receptor regulation.
Nuclear receptors (Biochemistry) Retinoids -- Receptors. Genetic regulation. Medical Term Receptors, Cytoplasmic and Nuclear -- genetics Receptors, Retinoic Acid -- genetics.
Nuclear receptors (NRs) are ligand-regulated transcription factors that control gene expression through interaction with coregulator proteins. Receptor interacting protein 140 (RIP140) is a ligand-inducible, ligand-dependent NR corepressor with...
Dartmouth Dissertations

The effects of acute exposure to hypoxia on physiological tremor in humans.
Anoxemia. ; Tremor.
Dartmouth Dissertations

The development of magnetic susceptibility weighted magnetoencephalography
Magnetoencephalography -- Technique.; Magnetic susceptibility.
The measurement of human brain function is the goal of many noninvasive medical imaging modalities. Two sources of physiological contrast are commonly targeted to achieve this goal. The most direct approach to measuring neuronal activity is with...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

Stereopsis-guided brain shift compensation.
Three-dimensional imaging in medicine -- Mathematical models. Intraoperative monitoring. Cerebral cortex -- Imaging. Computer vision. Space perception.
Brain deformation models have proven to be a powerful tool in compensating for soft tissue deformation during image-guided neurosurgery. The accuracy of these models can be improved by incorporating intraoperative measurements of brain motion. We...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Diffusion-weighted magnetic resonance imaging with high gradient fields.
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Dartmouth Dissertations

Efficient velocity estimation in doppler ultrasound imaging.
Doppler ultrasonography -- Mathematical models. Ultrasonic imaging -- Mathematical models. Signal processing -- Mathematical models. Wavelets (Mathematics). Scattering (Mathematics).
Dartmouth Dissertations

Combining near infrared tomography and magnetic resonance imaging to improve breast tissue chromophore and scattering assessment.
Breast -- Magnetic resonance imaging. Breast -- Tomography. Near infrared spectroscopy. Optical tomography. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models.
Dartmouth Dissertations

Development of a multi-high frequency electrical impedance tomography system for breast imaging.
Electrical impedance tomography. Breast -- Imaging. Imaging systems -- Design and construction.
Dartmouth Dissertations

Improvement and evaluation of nonlinear inversion MR elastography / by Matthew D. J. McGarry.
Magnetic resonance elastography (MRE) is a technique to produce images of the mechanical properties of tissue, which are indicative of a variety of diseases. Tissue motions measured using MRI are used to solve an inverse problem to recover...
Dartmouth Dissertations

The sexually dimorphic effects of prolactin on food intake by rats.
Prolactin. ; Rats -- Feeding and feeds. ; Sexual dimorphism (Animals).
Dartmouth Dissertations

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