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Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

The Vibrio cholerae AraC-like protein ToxT: activation of tcpA expression and domain organization.
Vibrio cholerae -- Molecular genetics. Genetic transcription -- Regulation. Promoters (Genetics). DNA-binding proteins.
ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Interactions among floral organ identity MADS proteins in Arabidopsis.
Arabidopsis -- Genetics. DNA-binding proteins. DNA-protein interactions. Transcription factors.
Plant MADS proteins play critical roles in vegetative and reproductive development. DNA binding and yeast three-hybrid assays suggest that plant MADS proteins function as dimers or multimers. However, little is known about how plant MADS proteins...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
Dartmouth Dissertations

A new synthetic route to B-ring derivatives of TMD
Bicyclic compounds -- Synthesis
Dartmouth Dissertations

Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
Dartmouth Dissertations

The effects of context and familiarity on person perception: examining the neural substrates of facial attractiveness.
Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
Dartmouth Dissertations

Investigation of the reactivity of nitrogen substituted oxyallyl cations.
Nitrogen compounds. Allyl compounds.
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

Hematopoiesis in the allantois and chorion.
Hematopoietic stem cells. ; Transcription factors. Placenta -- Cytology. Chorion -- Cytology. ; Cellular signal transduction.
The placenta is the extra-embryonic tissue that mediates the exchange of oxygen and nutrients between the fetus and mother. It was shown that the placenta is a source of hematopoietic stem cells (HSCs). However, it is not known whether the placenta...
Dartmouth Dissertations

Roles for protein phosphatases in cell survival and cell death pathways.
Apoptosis. ; Phosphoprotein phosphatases -- Inhibitors. ; Cellular signal transduction. ; Genetic transcription -- Regulation.
Apoptosis is important for tissue homeostasis and is the mechanism of cell death induced by many anticancer agents. The apoptotic machinery is present in all cells, such that tight regulation must exist to prevent untimely cell and tissue death. To...
Dartmouth Dissertations

The novel p53 target gene STK17A : implications for cancer therapy / by Pingping Mao
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

On the origins of cancer cell identity : epigenetic deregulation of cellular states / by Kevin Johnson
The identification of molecular alterations present in cancer is critical to better understand carcinogenesis as well as the clinical trajectories of patients with malignant tumors. Early detection and application of appropriate treatment...
Dartmouth Dissertations

Biophysical and ligand-binding characterization of the interleukin-2 receptor ß-subunit ectodomain.
Interleukin-2. ; T cells -- Receptors. ; Ligand binding (Biochemistry).
Dartmouth Dissertations

Regulation of epithelial chloride channels: implications for cell volume regulation and cystic fibrosis.
Chloride channels. ; Epithelial cells. ; Cellular control mechanisms. ; Cystic fibrosis.
Dartmouth Dissertations

Neo-architectonics computer-aided histological examination of the human visual cortex.
Visual cortex -- Imaging. ; Visual cortex -- Histology. ; Image processing -- Digital techniques.
Functional neuroimaging has confirmed a high degree of localization of function in the cerebral cortex of man. In contrast, microstructural analysis has contributed very little to the topographical characterization of cortical areas. In this work I...
Dartmouth Dissertations

Functional analysis of the Runx1 C-terminal sequences.
Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
Dartmouth Dissertations

Investigating ACAT allosterism.
Acyltransferases. Allosteric proteins. Esterification. Cholesterol -- Metabolism.
Acyl coenzyme A:cholesterol acyltransferase (ACAT) is a membrane bound enzyme whose primary biochemical activity is to convert cholesterol, along with long chain fatty acyl Coenzyme A, into cholesterol esters. ACAT plays an important role in the...
Dartmouth Dissertations

Biophysical analysis of the role of γc in the assembly of the interleukin-2 receptor.
Interleukin-2. ; T cells -- Receptors. ; Structure-activity relationships (Biochemistry). ; Biophysics.
Dartmouth Dissertations

Molecular Replacement for Nuclear Magnetic Resonance: application to NMR resonance assignment and protein structure determination.
Nuclear magnetic resonance spectroscopy -- Data processing. ; Proteins -- Analysis -- Mathematical models. ; Computer algorithms.
Our aim is to enhance high-throughput applications of Nuclear Magnetic Resonance (NMR) through the development of efficient computational methods that operate on sparse (minimal) sets of experimental NMR data. We have developed a family of four...
Dartmouth Dissertations

HIF1A-mediated STAT3 activation promotes self-renewal and malignancy of stem-like cells derived from spontaneous murine glioma.
Stem cells. ; Cerebral anoxia. ; Genetic transcription -- Regulation. ; Gliomas. ; STAT3 Transcription Factor. ; Hypoxia-Inducible Factor 1 alpha Subunit.
Dartmouth Dissertations

Cloning and expression of HVACM, a cullin protein, from small cell lung cancer.
Vasopressin -- Receptors. ; Small cell lung cancer. ; Genetic regulation. ; Molecular cloning. ; Immunohistochemistry.
Dartmouth Dissertations

Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae.
Iron-sulfur proteins.
Dartmouth Dissertations

Characterization of CTL responses to the murine AIDS defective retrovirus.
Retroviruses. ; AIDS (Disease). ; Mouse leukemia viruses. ; Diseases -- Causes and theories of causation. ; Antineoplastic antibiotics. ; MHC antibodies.
Dartmouth Dissertations

Iron uptake in Arabidopsis thaliana.
Arabidopsis thaliana. ; Iron -- Metabolism. ; Growth (Plants). ; Plants -- Effect of iron on.
Dartmouth Dissertations

Analysis of intracellular ion homeostasis during apoptotic cell death.
Apoptosis. ; Endonucleases. ; Calcium ions. ; Magnesium ions. ; Hydrogen-ion concentration.
A hallmark of apoptosis is internucleosomal DNA fragmentation catalyzed by an endogenous endonuclease. Many laboratories have implicated the activation of Ca2+/Mg2+-dependent endonucleases or the acid-dependent deoxyribonucleases, (DNase II),...
Dartmouth Dissertations

Characterization of type IVb pilus components essential for functional TCP of Vibrio cholerae O395, including implications on the hierarchy of microcolony formation and virulence / by Jarrad Matthew Marles.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Virulence (Microbiology) -- Molecular aspects. ; Fimbriae Proteins.
Vibrio cholerae is the etiological agent of the acute intestinal disorder cholera. The source of cholera infection is typically fecal contamination of potable water sources. V. cholerae is able to colonize the host intestine and trigger the onset...
Dartmouth Dissertations

On the leukemogenic mechanisms of core binding factor translocation products.
Transcription factors -- Pathophysiology. Myeloid leukemia -- Genetic aspects. Genetic transcription -- Regulation.
Core binding factor translocations and inversions are among the most frequently identified mutations in acute myeloid leukemia. We present work that characterizes the functional contributions of domains within the fusion proteins resulting from the...
Dartmouth Dissertations

Investigation of the human monocyte receptors CD163 and CD64.
Cell receptors. Fc receptors. Monocytes. Immune response -- Regulation. Proteins -- Immunology. Receptors
Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
Dartmouth Dissertations

Structural studies of dihydrofolate reductase-thymidylate synthase from Toxoplasma gondii and dynamin 1 from Rattus norvegicus.
Microbial enzymes -- Structure. Antiprotozoal agents -- Design. Toxoplasma gondii. Guanosine triphosphatase -- Structure. G proteins -- Structure. Thymidylate synthase-dihydrofolate reductase -- chemistry. Dynamins -- chemistry.
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Dartmouth Dissertations

Graphical models of sequence constraints on protein families.
Amino acid sequence -- Computer simulation. Proteins -- Structure -- Computer simulation. Proteins -- Conformation -- Computer simulation.
Proteins, the basic structural and functional building blocks of cellular machinery, evolve under significant constraint. Evolutionary pressures limit the acceptable variation and covariation of amino acids in a protein. As such, these evolutionary...
Dartmouth Dissertations

Head direction cells, grid cells, and the neural basis of spatial orientation
Space perception -- Physiological aspects.;""Thalamus -- Physiology."";""Hippocampus (Brain) -- Physiology."";""Neural networks (Neurobiology)"";""Neural Pathways -- physiology."";""Anterior Thalamic Nuclei -- physiology"";""Entorhinal Cortex --...
Dartmouth Dissertations

Cross-kingdom communication: The role of quorum sensing signals in Candida albicans and Pseudomonas aeruginosa interactions.
Pseudomonas aeruginosa -- Molecular genetics. Candida albicans. Pseudomonas aeruginosa infections. Plant-pathogen relationships. Cystic fibrosis -- Immunological aspects. Virulence (Microbiology) -- Molecular aspects. Medical Terms: Farnesol;...
The overall scope of my thesis project is to determine effects of farnesol, a secreted factor produced by C. albicans , on P. aeruginosa virulence. These two organisms are frequently found with one another in mixed infections and our lab has...
Dartmouth Dissertations

The impact of sodium channel isoform expression on cerebellar Purkinje cell development.
Purkinje cells. Sodium channels -- Genetic aspects. Excitation (Physiology). Neurons -- Physiology. Cerebellum -- Physiology. Genetic regulation.
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Dartmouth Dissertations

Physiology and kinetics of cellulose fermentation by Clostridium thermocellum / by Evert K. Holwerda
Cellulolytic microorganisms hold promise for industrially applied microbial cellulose utilization in the generation biofuels from renewable resources. Consolidated bioprocessing (CBP), a one-step process combining cellulase production, cellulose...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

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