Synthetic electrochemistry is a rapidly growing area of interest within the synthetic community, although it is far from being a routine technique. Despite the fact that many oxidative and reductive conversions are known, electrochemical methods...
Chromium -- Toxicity testing. ; Glutathione. ; Vitamin C -- Physiological effect. ; Carcinogenesis. ; DNA damage.
Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...
Free radicals (Chemistry). ; Electron donor-acceptor complexes. ; Ions.
In this study, the initial charge separation distance and its impact on free radical ion (FRI) formation are investigated in detail. Transient photocurrent techniques together with other spectroscopic methods were used with a series of donors and...
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Nitric oxide -- Analysis. ; Dithiocarbamates. ; Iron compounds. ; Organonitrogen compounds. ; Electron paramagnetic resonance spectroscopy.
Nitric oxide is synthesized by living organisms and plays important roles in circulatory, neurological, and immune function. Nitric oxide can also play pathophysiological roles, depending on the amount of the molecule, the presence of other species...
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
I investigated the effects of two contemporary disturbances to soil systems: forest clearing in the northeastern U.S. and climate-driven plant succession in the Arctic. To test the effects of clear-cutting forests on mineral soil carbon (C)...
In this thesis we develop a theory of Fourier analysis and fast Fourier transforms (FFTs) for finite inverse semigroups. Our results generalize results in the theory of Fourier analysis for finite groups. There is a general method for generating...
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Part I. A photoprecursor for difluorocarbene . The goal of this research was to develop a more practical and efficient photoprecursor for difluorocarbene. The first approach was concerned with the synthesis of 4,4-difluoropyrazoline-3,5-dione ( 5...
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
In the Firefighter Problem, a fire starts at a vertex of a graph, and in discrete time units, it spreads from burned vertices to their neighbors, unless they are protected by one of the f firefighters that are deployed every turn. Once burned or...
We have created an E. coli based platform for protein modification by coupling an engineered glycosylation pathway with a subsequent chemoenzymatic labeling strategy in which the glycans are oxidized to provide a bioorthogonal aldehyde group that...