Dartmouth Digital Library Program

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Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Dartmouth Dissertations

The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations

The adaptation of a potential function controller for control of a dynamic multi-robot system.
Robots -- Control systems -- Design and construction. Mobile robots. Robots -- Dynamics.
This thesis examines the issues of vehicle and information dynamics in the control of a multi-robot system using a radial-basis potential function controller. Distributed control of multi-robot systems requires each robot to communicate state...
Dartmouth Dissertations

The impact of prenatal and postnatal home visiting on utilization of care.
Home care services -- Utilization -- New Hampshire. Home care services -- New Hampshire -- Evaluation. Maternal health services -- Utilization -- New Hampshire. Infant health services -- Utilization -- New Hampshire. Prenatal care -- Utilization --...
Research objective . Research suggests that home visiting services can have a significant impact on pregnancy outcomes, child health and development, parenting and maternal life course. The effect of home visiting on utilization of health services...
Dartmouth Dissertations

The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
Mitochondria. Enzymes. ; Rats.
Dartmouth Dissertations

Studies in the statistical mechanics of chain molecules: applications of the wormlike chain and models for chain molecule dynamics
Molecular dynamics. Polymers.
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

Bottom-up effects of nutrient enrichment on plants, pollinators, and their interactions.
Meadow ecology -- Colorado. Angiosperms -- Nutrition. Angiosperms -- Pollination. Plants -- Effect of nitrogen on. Insect pollinators -- Ecology -- Colorado. Mountain plants -- Ecology -- Colorado. Bees -- Ecology -- Colorado. Bees -- Nutrition --...
Nutrients play fundamental roles in biological systems, affecting plant growth and quality, community structure, and species interactions. Although the effects of nutrients on primary and secondary production have been well documented, their...
Dartmouth Dissertations

Teaching diverse orthopaedic patient populations about deliberative decision making skills : testing a design strategy for online patients' decision aids
Clinical medicine -- Decision making. ; Medical informatics. ; Patient participation. ; Osteoarthritis -- Treatment. ; Knee -- Diseases -- Treatment. ; Decision Making. ; Decision Support Techniques.
Problem Statement. Effective patients' decision aids (PtDAs) help patients understand clinical information and reduce decisional conflict. PtDAs that also explicitly provide guidance through four """"Deliberative Steps"""" may achieve additional...
Dartmouth Dissertations

Structural and compositional aspects of low-grade metamorphic chlorite.
Chlorites. Metamorphism (Geology). ; Clay -- Analysis -- Maine. ; Clay -- Analysis -- Pennsylvania.
Dartmouth Dissertations

Efficient parallel algorithms for closest point problems.
Computer algorithms. ; Parallel processing (Electronic computers). ; Geometry -- Data processing.
Dartmouth Dissertations

Securing operating systems through utility virtual machines / by Robert Denz
The advent of hypervisors revolutionized the computing industry in terms of malware prevention and detection, secure virtual machine managers, and cloud resilience. However, this has resulted in a disjointed response to handling known threats...
Dartmouth Dissertations

Characterization of cancer risk and response to immunotherapy through pathway-based genomic analyses / by David C. Qian
For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
Dartmouth Dissertations

Algorithmic problems arising in posets and permutations / by Shahrzad Haddadan
Partially ordered sets and permutations are combinatorial structures having vast applications in theoretical computer science. In this thesis, we study various computational and algorithmic problems related to these structures. The first chapter of...
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Measuring quality of life in economic evaluations of treatment for severe mental illness.
Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Evidence based practice in neonatal intensive care: the effect of prophylactic topical emollient ointment therapy and systemic antibiotic administration practices on nosocomial sepsis rates and mortality in extremely low birth weight infants 501 to...
Neonatal intensive care. ; Evidence-based medicine. ; Nosocomial infections -- Prevention. ; Ointments -- Effectiveness. ; Antibiotics -- Effectiveness.
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
Dartmouth Dissertations

Characterization of two Saccharamyces cerevisiae genes involved in mRNA export.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics. ; Proteins -- Synthesis -- Genetic aspects.
I report the further characterization of an essential S. cerevisiae nucleoporin, RAT7/NUP159, shown previously to be involved in mRNA export. The Rat7p/Nup159p can be divided into three domains: an N-terminal domain, a central repeat domain, and a...
Dartmouth Dissertations

Evolution in fickle environments: dispersal, specialization, and the problem of heterogeneity.
Caenorhabditis elegans -- Ecology. ; Ecological heterogeneity. ; Evolution (Biology). ; Adaptation (Biology). ; Nematodes -- Dispersal.
All ecological theories regarding the distribution and relative abundance of species refer to organisms'' abilities to utilize an environment and (sometimes implicitly) their ability to colonize and re-colonize habitats that change in character or...
Dartmouth Dissertations

New measurements of equatorial spread-F: high-altitude irregularities and drifting bubbles.
Plasma instabilities. ; Ionospheric electron density. ; Ionosphere.
As a result of an unstable plasma stratification the nighttime equatorial ionosphere is subject to a variety of plasma instabilities known commonly as equatorial spread-F. In its fully developed form spread-F consists of large wedges of depleted...
Dartmouth Dissertations

Forming, operating, and improving micro-systems of health care.
Clinical medicine -- Practice. ; Medicine -- Practice. ; Group medical practice.
Health care micro-systems are small, organized groups of clinicians and staff working together with a shared clinical purpose to provide care for a defined set of patients. The size of individual micro-systems vary--a micro-system must be large...
Dartmouth Dissertations

Monitoring late radiation damage in normal muscle tissue with electrical impedance spectroscopy.
Muscle cells -- Effect of radiation on. ; Radiation -- Physiological effect. ; Electrical impedance tomography. ; Spectroscopic imaging.
Dartmouth Dissertations

Seedling ecology and tree diversity in a Bornean rain forest.
Trees -- Seedlings -- Ecophysiology -- Indonesia -- Kalimantan. ; Rain forest ecology -- Indonesia -- Kalimantan. ; Rain forest plants -- Ecophysiology -- Indonesia -- Kalimantan. ; Species diversity -- Indonesia -- Kalimantan. ; Palung Mountain...
Dartmouth Dissertations

Intuitive user-guided appearance editing.
Image processing -- Digital techniques. ; Computer algorithms. ; Human-computer interaction.
We present new appearance editing algorithms that allow artists to perform complex editing operations on spatially-varying appearance datasets such as images and measured materials, in an intuitive and efficient manner. The goal is to develop...
Dartmouth Dissertations

Accessibility of equilibria in an electron beam plasma system.
Plasma (Ionized gases). ; Plasma stability.
Dartmouth Dissertations

Random quantum dynamics : from random quantum circuits to quantum chaos.
Quantum computers. ; Quantum chaos. ; Many-body problem. ; Hamiltonian systems.
Dartmouth Dissertations

Large-scale structure of the universe: a clustering analysis.
Cosmology -- Mathematical models. ; Galaxies -- Clusters -- Mathematical models. ; Dark matter (Astronomy).
Dartmouth Dissertations

Intraspecific spatial variation in bird abundance: patterns and processes.
Songbirds -- Ecology -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds -- Habitat -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds -- Behavior -- New Hampshire -- Hubbard Brook Experimental Forest. ; Songbirds --...
Within a species, the abundance of individuals varies in time and space. This dissertation research examines processes giving rise to patterns of spatial and temporal variation in the abundance of multiple species of forest-breeding migratory...
Dartmouth Dissertations

Linking behavioral, population, and community ecology: consequences of oviposition-site selection in tree hole metacommunities.
Mosquitoes -- Ecology. ; Mosquitoes -- Behavior. ; Insect communities. ; Habitat selection
Though researchers have advocated a more direct link between individual, population, and community processes, translating the behavior of individuals to the dynamics of natural populations and communities has remained a major challenge in ecology....
Dartmouth Dissertations

Biophysical analysis of the role of γc in the assembly of the interleukin-2 receptor.
Interleukin-2. ; T cells -- Receptors. ; Structure-activity relationships (Biochemistry). ; Biophysics.
Dartmouth Dissertations

Chronostratigraphic variability in fluvial sequences as revealed by paleomagnetic isochrons: examples in Miocene strata from a central Andean intermontane basin (Salla, Bolivia) and the northwest Himalayan foreland (lower Siwalik Group, Chinji...
Stratigraphic correlation -- Bolivia. ; Stratigraphic correlation -- Pakistan. ; Geology Stratigraphic -- Miocene. ; Sedimentology.
Dartmouth Dissertations

Reaggregation of sea urchin embryonic cells.
Sea urchins -- Embryos. ; Embryology Experimental. ; Cell aggregation.
Dartmouth Dissertations

Cuts and decompositions: structure and algorithms.
Combinatorial optimization. ; Decomposition (Mathematics). ; Algorithms. ; Partially ordered sets.
Dartmouth Dissertations

The Vibrio cholerae AraC-like protein ToxT: activation of tcpA expression and domain organization.
Vibrio cholerae -- Molecular genetics. Genetic transcription -- Regulation. Promoters (Genetics). DNA-binding proteins.
ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Dissertations

Preventing private information leakage in sensor networks.
Sensor networks -- Security measures. ; Data protection. ; Database security.
Sensor networks are used in many realtime applications for collecting information from monitored environments and objects, such as moving vehicle tracking, battlefield reconnaissance, and habitat monitoring. Sensor networks are often deployed in...
Dartmouth Dissertations

The evolution of ecologically important traits in larval anurans.
Tadpoles -- Ecology -- Atlantic States. ; Anura -- Evolution -- Atlantic States. ; Tadpoles. ; Bufonidae -- Atlantic States. ; Ranidae -- Atlantic States. ; Hylidae -- Atlantic States.
Understanding the distribution of species is a long-standing goal of ecology. Progress toward this understanding requires elucidation of how present-day patterns have been generated through history. Accomplishing this demands the study of...
Dartmouth Dissertations

The metric of visual space.
Space perception -- Measurement. ; Visual perception -- Measurement. ; Visual perception.
Dartmouth Dissertations

Neural representation of social knowledge in the medial prefrontal cortex.
Social perception -- Physiological aspects. ; Prefrontal cortex -- Physiology.
From the most minimal of person information, such as a photograph or a sentence, people are able to rapidly infer a multitude of complex personality traits. These social inferences are thought to rely upon cognitive representations of person...
Dartmouth Dissertations

Large bowel polyps: aspects of epidemiology and diagnosis.
Intestine, Large -- Cancer -- Epidemiology. ; Intestine.
Colorectal cancer is the fourth most common cancer diagnosis and the second leading cause of cancer-related death in the United States. Most colorectal cancers are believed to develop from precursor lesions known as colorectal adenomas....
Dartmouth Dissertations

Game-theoretic approaches for adversarial multi-armed bandit scenarios.
We pose several adversarial variants of the multi-armed bandit scenario and propose new approaches for their play and analysis. Our casino patron seeks to discover information about an unknown system as a means to long-term payoff -- exploration...
Dartmouth Dissertations

Operating system support for resilience / by Kathleen McGill.
Robots. ; Reinforcement learning. ; Social interaction. ; Cooperation. ; Biomimetics.
Dartmouth Dissertations

State representation for agent-based reinforcement learning.
Agent-based policy learning in complex and uncertain environments is challenged by escalating computational complexity with the size of the task space (action choices and environmental states) as well as the number of agents. Nonetheless, there is...
Dartmouth Dissertations

Graphical models of sequence constraints on protein families.
Amino acid sequence -- Computer simulation. Proteins -- Structure -- Computer simulation. Proteins -- Conformation -- Computer simulation.
Proteins, the basic structural and functional building blocks of cellular machinery, evolve under significant constraint. Evolutionary pressures limit the acceptable variation and covariation of amino acids in a protein. As such, these evolutionary...
Dartmouth Dissertations

Temporal variability in the abundance and species composition of forest hervibores.
Forest ecology -- New Hampshire -- Hubbard Brook Experimental Forest. Lepidoptera -- New Hampshire -- Hubbard Brook Experimental Forest. Forest insects -- New Hampshire -- Hubbard Brook Experimental Forest. Insect populations -- New Hampshire --...
One of the principle aims of ecology is to understand variations in organism abundance over time. Some species and species assemblages exhibit exceptionally dynamic changes in abundance or biomass, while other species and species assemblages are...
Dartmouth Dissertations

Development and investigation of a decision support system to facilitate shared decision making in community mental health.
Community mental health services -- Decision making. Mentally ill -- Care -- Decision making. Psychotherapist and patient.
Background. Electronic decision support systems (EDSS) using a shared decision making framework may be a new technology to facilitate service planning in public sector mental health care. The case management context is a ripe testing ground for...
Dartmouth Dissertations

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