Dartmouth Digital Library Program

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Aluminum migration and chemical weathering in subalpine and alpine soils and tills, Mt. Moosilauke, N.H.: the effects of acid rain.
Soils -- Aluminum content. ; Acid rain. ; Soil chemistry. ; Moosilauke Mount (New Hampshire).
Dartmouth Dissertations

Synthetic studies on sarpagine alkaloids.
Alkaloids. Organic compounds -- Synthesis.
Dartmouth Dissertations

Performance decrement following insolvable problems: learned helplessness or failure anxiety?
Failure (Psychology);Helplessness (Psychology)
Dartmouth Dissertations

Distribution of sessile rotifers in a bog pond : with particular emphasis on substrate selection by Ptycura Beauchampi larvae
Rotifera. Ptychura Beauchampi.
Dartmouth Dissertations

Laser-based oxygen isotopic studies of Acadian metamorphism in eastern Vermont.
Metamorphism (Geology) -- Vermont. Garnet -- Vermont. Laser spectroscopy.
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Mechanisms by which arsenite decreases CYP3A.
Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

Effects of foliage structure on the foraging behavior of insectivorous forest birds.
Wood warblers -- Food. ; Wood warblers -- Behavior. Leaves. ; Forest ecology.
Dartmouth Dissertations

Using the eyes to measure the mind : pupil dialation dynamics as a biomarker of online attention / by Olivia E. Kang
Every moment of our waking lives, our brains filter large quantities of sensory data for goal relevant information. This ability to modulate our sensitivity to incoming inputs is critical in the face of an otherwise overwhelming world, and...
Dartmouth Dissertations

Interrogation of autolysins as a source of novel bacteriolytic agents / by Daniel Carmen Osipovitch
Staphylococcus aureus is a formidable pathogen, and its high morbidity and mortality rates are compounded by its ability to quickly develop antibiotic resistance. The current antimicrobial pipeline is inadequate to curb this mounting public health...
Dartmouth Dissertations

A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

Neurohypophysial function during acute stimulation in rats: role of vasopressin in regulation of blood pressure and oxytocin release.
Blood pressure. ; Vasopressin. ; Neurophysiology. ; Rats as laboratory animals.
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

Synthesis and bond alternation of azulene derivatives.
Azulene -- Derivatives -- Synthesis. ; Polycyclic aromatic hydrocarbons -- Synthesis. ; Crystallography. ; Chemical bonds.
5,6-Azulyne, the first azulyne to be prepared, has been trapped with furan to give an adduct whose crystal structure reveals marked bond alternation in the azulene pi system. The double bond in the furan moiety is responsible in part for the bond...
Dartmouth Dissertations

An effective distributed caching strategy for partial result reuse for discrete optimization problems.
Evolutionary computation. ; Cache memory. ; Mathematical optimization. ; Protein folding -- Computer simulation.
Evolutionary Computation (EC) is one of the most advanced computational techniques. It has been frequently and successfully used to find good solutions to many complicated optimization problems with limited computational resources. EC is the...
Dartmouth Dissertations

The mitotic protein p62 is localized to the nucleolus during interphase.
Nucleoproteins. ; Mitosis. ; Nucleolus. ; Molecular biology.
Mitotic apparatuses from sea urchin embryos contain a protein (p62), previously shown to be required for mitotic progression. This protein localizes to the mitotic apparatus during cell division in urchin embryos and mammalian tissue culture cells....
Dartmouth Dissertations

Synthetic approaches to indolo[2,3-a]carbazole alkaloids.
Indole alkaloids -- Synthesis. ; Carbazole.
Dartmouth Dissertations

Reactions of cyclopropane nucleophiles with α-formyl ketone derivatives.
Cyclopropane. ; Ketones.
Dartmouth Dissertations

Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region.
Cytochrome P-450. ; Genetic regulation. ; Genetic transcription.
Dartmouth Dissertations

The molecular basis of chromium carcinogenesis.
Chromium. ; Carcinogens.
Dartmouth Dissertations

Application of Rayleigh's short-cut method to Polya's recurrence problem.
Random walks (Mathematics). ; Lattice theory.
Dartmouth Dissertations

Behavioral and neural investigations of behaviorally relevant features of auditory stimuli.
Auditory pathways -- Physiology. ; Auditory perception -- Physiological aspects. ; Directional hearing -- Physiological aspects. ; Speech perception -- Physiological aspects. ; Prefrontal cortex -- Physiology. ; Parietal lobes -- Physiology. ;...
Studies of the structure and function of the human and non-human primate auditory system have led to the hypothesis that it is composed of dorsal and ventral processing streams that are respectively dedicated to spatial and non-spatial processing....
Dartmouth Dissertations

Cytotoxic trigger molecules on human myeloid cells.
Cell-mediated cytotoxicity.
Dartmouth Dissertations

On the quantum kinetic theory of high energy plasmas.
Quantum theory. ; Plasma (Ionized gases).
Dartmouth Dissertations

Characterization of ccg-1, a clock-controlled gene of Neurospora crassa.
Biological rhythms. ; Genetic regulation. ; Neurospora crassa.
Dartmouth Dissertations

The energetic importance of terrestrial carbon in lake ecosystems.
Microbial ecology. ; Microbial metabolism -- Regulation. ; Lakes -- Organic compound content. ; Lake ecology. ; Soils -- Leaching -- Environmental aspects. ; Carbon cycle (Biogeochemistry).
Dartmouth Dissertations

General nonlinear mechanics of an electron beam driven multimode plasma system.
Electron beams. ; Nonlinear mechanics. ; Plasma (Ionized gases).
Dartmouth Dissertations

Requirements for the signaling of lysosomal secretion: two studies.
Lysosomes. ; Secretion.
Dartmouth Dissertations

Mechanisms for chromium-induced signaling changes in pulmonary epithelial cells.
Chromium -- Pathophysiology. ; Lungs -- Pathophysiology. ; Epithelial cells. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Protein kinases -- Pathophysiology. ; src-Family Kinases. ; Mitogen-Activated Protein Kinases.
Both human epidemiological and animal studies have associated inhalation of chromium(VI) (Cr(VI)) with increased incidence of pulmonary disease. This thesis examined the hypotheses that Cr(VI) activates cell signaling through kinase cascades and...
Dartmouth Dissertations

Cholesterol trafficking and the etiology of NPC disease.
Cholesterol -- Physiological transport. ; Cholesterol -- Genetic aspects. ; Purkinje cells. ; Neurogenetics. ; Neimann-Pick Diseases -- etiology.
Niemann-Pick type C (NPC) disease is a fatal autosomal recessive pediatric neurovisceral disorder characterized clinically by progressive neurodegeneration in the central nervous system (CNS) and hepatosplenomegaly. Biochemically, it is...
Dartmouth Dissertations

Effects of estrogens on induction of cytochrome P450 in cultured hepatocytes.
Cytochrome P-450. ; Enzyme induction. ; Estrogen.
Dartmouth Dissertations

Climate and vegetation change in the Himalayan foreland from oxygen and carbon isotope ratios of fossils and paleosol clays and calcite.
Paleoecology -- Himalaya Mountains Region. ; Paleoclimatology -- Himalaya Mountains Region. ; Fossils -- Himalaya Mountains Region. ; Paleopedology -- Himalaya Mountains Region. ; Calcite -- Himalaya Mountains Region. ; Stable isotope tracers.
Dartmouth Dissertations

Characterization of CTL responses to the murine AIDS defective retrovirus.
Retroviruses. ; AIDS (Disease). ; Mouse leukemia viruses. ; Diseases -- Causes and theories of causation. ; Antineoplastic antibiotics. ; MHC antibodies.
Dartmouth Dissertations

Interaction of chromium with nucleic acids and protein: an in vitro and in vivo study.
Chromium. ; Nucleic acids. ; Proteins.
Dartmouth Dissertations

Synthetic, mechanistic, photochemical studies of highly fluorinated organic compounds. Part I; Perfluorobicyclo[2.2.0]hex-1(4)-ene. Part II.
Organofluorine compounds -- Synthesis. ; Organofluorine compounds -- Thermal properties. ; Fluorination. ; Photochemistry.
Dartmouth Dissertations

Cu(I)-catalyzed P-C bond formation and the synthesis of C₃- and C₁-symmetric p-stereogenic triphosphine ligands / by Matthew F. Cain.
Cell cycle -- Regulation.; Transcription factors.; Luciferases.; Forkhead Transcription Factors -- genetics.
Dartmouth Dissertations

Immunomodulatory effects of chronic low dose arsenic exposure.
Arsenic -- Toxicology. Lungs -- Diseases -- Immunological aspects. Lungs -- Diseases -- Genetic aspects. Medical Term Arsenic -- toxicity.
Toxic metals are a major health concern in the environment and particularly in Superfund and other toxic waste sites. Arsenic (As) is considered the number one environmental chemical of human health concern both in the U.S. and worldwide. It is...
Dartmouth Dissertations

Synthesis and characterization of phosphido-coated gold nanoclusters and gold phosphido complexes.
Gold -- Analysis. Gold compounds. Metal complexes -- Synthesis. Phosphides. Ligands.
Chapter one: Gold(I) phosphido complexes: Synthesis, structure and reactivity . Deprotonation of the phosphine complexes Au(PHR 2 )Cl with aqueous ammonia gave the gold(I) phosphido complexes [Au(PR 2 )] n (PR 2 = PMes 2 ( 1 ), PCy 2 ( 2 ), P(t-Bu)...
Dartmouth Dissertations

Phospho-regulation of the kinesin-13 Kif2b ensures error-free mitosis
Solid tumors are frequently aneuploid and many display high rates of ongoing chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT)...
Dartmouth Dissertations

Prediction of the thermodynamic properties of branched polymer solutions and copolymer systems / by Elizabeth Alice Clark.
Throughout this work, a lattice model was used to capture the behavior of polymer systems. First, the phase behavior of solutions which contain polymer solute in an alkane solvent was investigated. The phase diagrams of these solutions are...
Dartmouth Dissertations

Synthetic studies of Munchnone reactivity and applications and the total synthesis of cyclopenta[B]indole natural products / by Justin M. Lopchuk.
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

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