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Development of an apparatus for simultaneous trapping of ⁶Li-⁸⁷Rb Fermi-Bose mixtures.
Trapped ions -- Instruments. Magnetooptical devices -- Design and construction. Atoms -- Cooling. Lithium ions. Rubidium -- Isotopes.
Dartmouth Dissertations

Multiple element intraoperative ultrasound hyperthermia system.
Operative ultrasonography -- Instruments. ; Cancer -- Thermotherapy -- Instruments.
Dartmouth Dissertations

The Vibrio cholerae AraC-like protein ToxT: activation of tcpA expression and domain organization.
Vibrio cholerae -- Molecular genetics. Genetic transcription -- Regulation. Promoters (Genetics). DNA-binding proteins.
ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Dissertations

Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
Dartmouth Dissertations

A molecular and genetic analysis of the requirement of SadB for modulating surface-associated behaviors in Pseudomonas aeruginosa PA14.
Biofilms. Pseudomonas aeruginosa -- Genetics. Pseudomonas aeruginosa -- Development. Bacteria -- Motility. Biofilms -- growth and development.
Pseudomonas aeruginosa is one of the model organisms used to study the developmental process of biofilm formation in Gram-negative bacteria. Recently, a genetic approach {O'Toole, 1998 #404} was taken to study biofilm formation in P. aeruginosa and...
Dartmouth Dissertations

A reciprocal relationship between Scavenger Receptor-A and toll-like receptor 4 in bacterial phagocytosis and endotoxic shock resistance.
Cell receptors. Phagocytosis -- Immunological aspects. Septic shock -- Immunological aspects. Bacterial diseases -- Immunological aspects. Natural immunity. Medical Term Receptors, Cell Surface -- physiology. Toll-Like Receptors -- physiology.
An organism's long-term survival is critically dependent on its ability to protect itself from pathogenic microbial infections. The first line of defense against such infections is the branch of the immune response referred to as the innate immune...
Dartmouth Dissertations

Natural and engineered metabolism of Thermoanaerobacterium saccharolyticum during growth on plant derived mono- and polysaccharides / by Devin Hedley Currie.
Many microbes thrive in conditions that would be detrimental to human life. These microorganisms have been dubbed extremophiles. Of these, members of a subcategory, termed thermophiles, grow optimally above 45°C. Thermoanaerobacterium...
Dartmouth Dissertations

Mechanisms of survival and persistence of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Proteins -- Secretion. Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of the severe diarrheal disease cholera. Colonization of the host environment by V. cholerae requires the type IV toxin co-regulated pilus (TCP). Adequate colonization by V. cholerae is essential for cholera...
Dartmouth Dissertations

Wnt pathway activation by ADP-ribosylation / by Eungi Yang
Wnt/[beta]-catenin signaling directs metazoan development and is aberrantly activated in many cancers; however, effective inhibitors to treat Wnt-driven cancers have long been elusive. Following the recent discovery that the ADPribose polymerase...
Dartmouth Dissertations

Specificity in signaling : bacterial decision-making through the cyclic diguanylate second messenger / by Kurt M. Dahlstrom
Cyclic diguanylate (c-di-GMP) is a primarily bacterial and nearly universal second messenger used to stimulate a variety of responses from the cell by binding effector proteins. It is created by enzymes called diguanylate cyclases (DGCs) and broken...
Dartmouth Dissertations

A rheological investigation of living cytoplasm.
Rheology (Biology). ; Cytoplasm.
Dartmouth Dissertations

Molecular analysis of heterochronic gene lin-14 and developmental cell cycle control in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Cellular control mechanisms. ; Cell cycle.
During postembryonic development of C. elegans the heterochronic gene lin-14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 transcripts are predicted to encode isoforms of a novel nuclear protein that...
Dartmouth Dissertations

Molecular characterization of the circadian clock: locus frequency of neurospora crassa.
Neurospora crassa. ; Circadian rhythms. ; Mutation (Biology).
Dartmouth Dissertations

Cosmological magnetic fields from inflation.
In this thesis we review the methods for computation of cosmological correlations in the early universe known as the in-in formalism which are then applied to the problem of magnetogenesis from inflation. For this computation, a power-law single...
Dartmouth Dissertations

Decentralized adaptive control for nonlinear interconnected systems with applications to real-time robot control.
Robots -- Control systems. ; Control theory. ; Robotics.
Dartmouth Dissertations

Characterization of catalase and its role in life-span determination in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Larvae. ; Caenorhabditis elegans -- Growth. ; Catalase -- Genetic aspects.
In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode...
Dartmouth Dissertations

Regulation of cohesion, recombination and chromosome core dynamics during Drosophila meiosis.
Drosophila -- Cytogenetics. Meiosis. Sister chromatid exchange. Chromosome Segregation.
Accurate chromosome segregation during mitosis and meiosis requires that sister-chromatid cohesion hold sisters together until the appropriate time. In addition, meiotic cohesion is necessary for normal synaptonemal complex (SC) and homologous...
Dartmouth Dissertations

The Pseudomonas fluorescens pho regulon and its role in modulating biofilm formation in response to environmental cues.
Pseudomonas fluorescens -- Genetics. Attachment mechanisms (Biology) Biofilms -- Growth. Phosphates -- Physiological effect. Medical Term: Biofilms -- growth and development. Adhesins, Bacterial.
Microbial biofilm formation is thought of as a developmental pathway, whereby cells progress through environmentally regulated and temporally distinct stages during transition from free-swimming lifestyles to members of a structured...
Dartmouth Dissertations

Nuclear receptor corepression, negative feedback and transcription-based oscillation: Evidence for a novel form of nuclear receptor regulation.
Nuclear receptors (Biochemistry) Retinoids -- Receptors. Genetic regulation. Medical Term Receptors, Cytoplasmic and Nuclear -- genetics Receptors, Retinoic Acid -- genetics.
Nuclear receptors (NRs) are ligand-regulated transcription factors that control gene expression through interaction with coregulator proteins. Receptor interacting protein 140 (RIP140) is a ligand-inducible, ligand-dependent NR corepressor with...
Dartmouth Dissertations

Post-translational regulation of the Neurospora crassa circadian system.
Post-translational modification. Circadian rhythms. Neurospora crassa -- Genetics. Genetic regulation. Phosphorylation. Medical Term Circadian Rhythm -- genetics.
Circadian rhythms are found ubiquitously throughout life on the planet. These biological clocks stem from common underlying molecular architecture revolving around a time-delayed feedback oscillator driving robust, approximately 24 hour rhythms. In...
Dartmouth Dissertations

Light responses and photoadaptation in Neurospora crassa.
Neurospora crassa -- Effect of light on. Neurospora crassa -- Genetics. Neurospora crassa -- Physiology. Neurospora crassa -- Molecular aspects. Genetic transcription -- Regulation.
WC-1 and WC-2 are essential for most light responses in Neurospora crassa, but the molecular mechanisms underlying gene induction and the roles of other real and putative photoreceptors remain poorly characterized. Unsupervised hierarchical...
Dartmouth Dissertations

Novel levels of Ras1 regulation in the human fungal pathogen, Candida albicans / by Amy Elizabeth Piispanen.
Neurotrophic functions.;""Growth factors."";""Exercise -- Physiological aspects."";""Cognition -- Effect of exercise on."";""Cognition -- physiology.""
Dartmouth Dissertations

Differential response in p53 wild-type cells to p53 activation by DNA damage and Nutlin-3
DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21waf1 protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor...
Dartmouth Dissertations

Genetic regulation of PBP2 and PBP4 in community-acquired methicillin-resistant Staphylococcus aureus
Staphylococcus aureus contains 4 native, membrane-bound penicillin-binding proteins (PBP1-4) which are responsible for critical peptidoglycan transglycosylation and transpeptidation reactions in the cell wall. Additionally, PBP2 and PBP4 also...
Dartmouth Dissertations

The effect of ionospheric outflow on the dynamics of magnetospheric convection
The ionosphere is an important source of plasma in the magnetosphere, especially during geomagnetic storms. While satellite data has confirmed this population of ions, their effect on the dynamics of the magnetosphere-ionosphere (MI) system is not...
Dartmouth Dissertations

c-di-GMP mediated regulation of the LapA biofilm adhesin through proteolysis by the calcium-dependent cysteine protease LapG / by Chelsea D. Boyd.
The localization of the putative adhesin LapA to the cell surface is a key regulatory step required by Pseudomonas fluorescens Pf0-1 to irreversibly attach to a surface and form a biofilm. LapA contains several domains conserved in predicted...
Dartmouth Dissertations

Pharmacological targeting of Wnt and Hedgehog pathways in lung cancer / by Alexander M. Busch
The Hedgehog (Hh) and Wnt pathways are key biological signaling pathways responsible for embryonic development, cellular proliferation, stem cell maintenance and self-renewal, and adult somatic tissue homeostasis. Because these pathways serve as...
Dartmouth Dissertations

Mechanistic insight as to how the formin FMNL3 assembles filopodia / by Ernest G. Heimsath, Jr.
Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Identification of the glucose transport system in purified rat adipose cell plasma membranes
Glucose -- Metabolism. Insulin -- Physiological effect.
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Dartmouth Dissertations

The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations

SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Towards the experimental verification of macroscopic phenomena in quantum electrodynamics.
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

The RNA binding landscape of the histone stem-loop binding protein / by Lionel (Lee) Brooks 3rd.
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
Dartmouth Dissertations

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