From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...
Neuroanatomical studies have defined two relatively separate corticohippocampal processing streams that contribute substantially to medial temporal lobe function. Among the cortical regions providing significant input to these processing streams is...
Agent-based policy learning in complex and uncertain environments is challenged by escalating computational complexity with the size of the task space (action choices and environmental states) as well as the number of agents. Nonetheless, there is...
Two alloys, Fe 55 Mn 19 Al 26 and Fe 30 Ni 20 Mn 35 Al 15 , were studied in this research project. The yield stress anomaly (YSA) of Fe 55 Mn 19 Al 26 single crystal was observed with a yield stress peak at 700 K. In situ TEM straining revealed...
Despite great progress in object recognition techniques, there is a mismatch between traditional approaches and the characteristics of real world vision tasks. We highlight in particular, three closely related areas of mismatch: i) recognition...
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Sexual selection is a driver of biodiversity and creates spectacular forms of variation. However, only recently have we begun to understand how this variation operates on the postcopulatory level and how cryptic mechanisms affect male-male...
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Mentally ill -- Care -- Decision making. Mental illness -- Treatment -- Decision making. Mental health services -- Decision making. Mental health -- Information services. Medical informatics. Mental Disorders -- drug therapy.
Objective. We explored preferences and perceptions about treatment decision-making roles among persons with severe mental illness and evaluated two computer-based medication values clarification tools. Methods. In this study we conducted a pilot...
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Information retrieval -- Mathematical models. ; Electronic information resource searching. ; Computer algorithms. ; Decision making -- Data processing. ; Mathematical optimization.
This thesis presents a unified method for simultaneous solution of three problems in Information Retrieval--metasearch (the fusion of ranked lists returned by retrieval systems to elicit improved performance), efficient system evaluation (the...
The experiments comprising this thesis aimed to characterize the neural and behavioral correlates of learning about and responding to the predictive information conveyed by social cues. Facial expressions are cues that convey critical information...
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Rats -- Behavior. Sexual behavior in animals. Vagina -- Psychophysiology. Cervix uteri -- Psychophysiology.
The present dissertation examined the contributions of vaginal and cervical stimulation to sexual motivation and reward in female rats. New, more complex behavioral methods such as the display of paced mating behavior and the induction of a...
The rat limbic system contains head direction (HD) cells that fire according to heading in the horizontal plane. These HD cells are thought to provide animals with an internal compass to guide navigation. Previous work has found that HD cell tuning...
Across mammalian species, adolescence is characterized by a unique combination of cognitive, behavioral and neurobiological changes. Behavioral tendencies observed during this period promote a variety of flexible interactions with the surrounding...
As the human population increases, it is imperative that we develop strategies to improve agricultural productivity to meet the growing demand for food, fuel and fiber. More than 2 billion people suffer from "hidden hunger" (a lack of essential...
GABA -- Receptors. ; GABA -- Physiological effect. ; Sexual behavior in animals. ; Hypothalamus -- Physiology.
The overall goal of this research has been to investigate sex-specific and region-specific differences in the function of the γ-aminobutyric acid type A (GABA[subscript A]) receptor in two regions of the brain which are essential for the...