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Regeneration of neuromuscular connections from allotransplanted ganglia in the crayfish.
Ganglia, Sensory -- Transplantation. ; Central nervous system -- Regeneration. ; Procambarus clarkii -- Nervous system. ; Neurons -- Innervation. ; Synapses.
Dartmouth Dissertations

Causes and consequences of DeltaNp63 expression in mammary epithelial progenitors.
Epithelium -- Tumors -- Genetic aspects. p53 antioncogene -- Regulation. Stem cells. Breast -- Cancer -- Genetic aspects. Breast -- Cancer -- Etiology. Medical Terms: TP63 protein, human; Tumor Suppressor Proteins -- genetics; Breast Neoplasms --...
Efforts to elucidate the events that account for breast cancer initiation have focused sharply on a small subset of mammary epithelial cells, referred to in this document at mammary stem cells, whose features may enable them to accumulate and...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

Seedling ecology and tree diversity in a Bornean rain forest.
Trees -- Seedlings -- Ecophysiology -- Indonesia -- Kalimantan. ; Rain forest ecology -- Indonesia -- Kalimantan. ; Rain forest plants -- Ecophysiology -- Indonesia -- Kalimantan. ; Species diversity -- Indonesia -- Kalimantan. ; Palung Mountain...
Dartmouth Dissertations

Impact of semen on mucosal transmission of HIV
Semen is the major vector for sexual transmission of HIV worldwide, yet little is known about its role in modulating mucosal transmission of HIV. Understanding the impact of semen on mucosal transmission of HIV could open up novel means of...
Dartmouth Dissertations

Temperature effects on food web interactions : from lakes to landscapes / by Samuel Butler Fey.
Temperature has powerful effects on all scales of biological organization from biochemical reactions to ecosystem processes. Despite the well-appreciated influence and thorough understanding of the physiological and population consequences of...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

The effects of food resources and conspecifics on the foraging, survivorship, and reproduction of the omnivorous copepod Epischura lacustris
Epischura; Epischura -- Food
Dartmouth Dissertations

Age-specific predation and predation risk of Chaoborus punctipennis.
Chaoborus. Predation (Biology). Freshwater ecology.
Dartmouth Dissertations

The effects of context and familiarity on person perception: examining the neural substrates of facial attractiveness.
Face perception -- Physiological aspects. Face perception -- Social aspects. Sex differences (Psychology). Neuropsychology.
The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...
Dartmouth Dissertations

Uterine epithelial cell release of MIP3, TNF and TGF in response to Escherichia coli, Lactobicillus rhamnosus and pathogen associated molecular patterns (PAMP) and the influence of estradiol on cytokine release.
Epithelial cells. Estradiol -- Physiological effect. Tumor necrosis factor. Transforming growth factors-beta. Cytokines -- Pathophysiology. Escherichia coli. Lactobacillus rhamnosus. Uterus -- Pathophysiology.
The research presented in this thesis tested the hypothesis that uterine epithelial cells (UEC) are selectively responsive to bacteria and pathogen associated molecular patterns (PAMP) and that responses are influenced by estradiol (E 2 ). We...
Dartmouth Dissertations

Effects of anabolic androgenic steroids on GABAA receptor function and expression.
Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; GABA -- Receptors. ; GABA -- Physiological effect. ; Neurotransmitter receptors. ; Brain -- Physiology. ; Receptors GABA-A -- drug effects.
Dartmouth Dissertations

Density-dependent dynamics in a tropical rain forest canopy tree.
Dipterocarpaceae -- Ecology -- Indonesia -- Kalimantan Barat. ; Rain forest ecology -- Indonesia -- Kalimantan Barat. ; Herbivores -- Ecology.
A decline in population growth as the abundance of a species increases can stabilize population size. In Western Borneo, I found evidence for such density dependence in juveniles of the genus Shorea (Dipterocarpaceae) that dominates southeast...
Dartmouth Dissertations

CD8 T cell responses to murine gamma-herpesvirus 68: viral persistence shapes the immune response.
T cells. Immunologic memory. Latent virus diseases -- Immunological aspects. Herpesvirus diseases. Cell-mediated cytotoxicity. CD8-Positive T-Lymphocytes -- immunology. T-Lymphocytes
Vaccines are one the greatest advances in public health. Vaccines work by priming cells of the adaptive immune system in such a way that they remember that they have encountered a specific antigen before. This then allows those cells to respond...
Dartmouth Dissertations

The expression and activity of TP63 in the mammary epithelial regenerative hierarchy.
Tumor proteins. ; p53 antioncogene. ; Epithelial cells. ; Mammary glands -- Cytology. ; Stem cells. ; Regeneration (Biology). ; Genetic transcription -- Regulation. ; Cellular signal transduction.
Dartmouth Dissertations

Determinants of reproductive success in a neotropical migratory songbird: timing, site-selection and mating strategies.
Ovenbird -- Fertility. Ovenbird -- Reproduction. Ovenbird -- Behavior. Ovenbird -- Ecology. Ovenbird -- Nests. Ovenbird -- Maryland -- Anne Arundel County. Courtship in animals -- Maryland -- Anne Arundel County. Brown-headed cowbird -- Maryland --...
Identifying and understanding sources of individual variation in fecundity is of central importance to life history theory and population ecology. In this study, I first examined how factors on the breeding grounds in eastern Maryland affected the...
Dartmouth Dissertations

Demography of a fragmentation-sensitive songbird: edge and ENSO effects.
Rufous-crowned sparrow -- Effect of habitat modification on. ; Rufous-crowned sparrow -- California Southern. ; Fragmented landscapes -- California.
The Rufous-crowned Sparrow (Aimophila ruficeps ; RCSP) is a non-migratory, ground-nesting songbird that resides in southern California coastal sage scrub, which has been highly fragmented by urban development. RCSP's spatial pattern of abundance...
Dartmouth Dissertations

Mast fruiting and seed predation in a northern hardwoods forest.
Forest ecology -- New Hampshire. ; Trees -- New Hampshire. ; Hardwoods.
Dartmouth Dissertations

The neuromodulatory influences of vasopressin on fear conditioning and spatial learning.
Vasopressin -- Physiological effect.
Dartmouth Dissertations

Synthetic and mechanistic studies in tetrapyrrole chemistry.
Tetrapyrroles -- Synthesis. Tetrapyrroles -- Mechanism of action. Transition metal catalysts.
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
Dartmouth Dissertations

The role of DRNL and microRNA319a in petal and stamen growth in Arabidopsis.
Arabidopsis thaliana -- Genetics. Growth (Plants).
Work in Arabidopsis and other model species over the past 25 years has led to major insights into the control of floral organ identity. However, much less is known about genes that control the growth and differentiation of floral organs. In this...
Dartmouth Dissertations

Effects of suburbanization on plant-pollinator interactions / by Adrian L. Carper.
Urban and suburban development is a dominant factor driving ecological processes at local and regional scales and its impacts on biodiversity and ecosystem services are alarming. Pollinators, especially bees, and the ecosystem services they...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

The evolution of mate recognition in Oecanthus tree crickets / by Laurel Symes.
Many organisms recognize and respond to categories: predator, prey, rival, or juvenile. Organisms recognize these ecologically-important categories by assessing diverse sensory stimuli. A primary focus of my research has been understanding how...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

The ecology and bioenergetics of the northern black-throated blue warbler.
Wood warblers.
Dartmouth Dissertations

Analysis of zooplankton dynamics: case studies of temporal succession controlled by the predator, Asplancha, and of diel cycles in Keratella.
Freshwater zooplankton. Predation (Biology).
Dartmouth Dissertations

Dissecting the heterogeneity of breast tumor subtypes / by Nima Pouladi.
Breast cancer is the most common cancer in women. The discovery of breast tumor subtypes and the subsequent development of treatments aimed at them has allowed a reduction in the mortality of breast cancer. However, tumors with similar...
Dartmouth Dissertations

Microbial mediation of plant-pollinator interactions / by Robert N. Schaeffer II.
Floral nectar of many plant species is prone to colonization by microorganisms. Their presence and metabolism have the potential to modify a suite of traits important for pollinator attraction, including nectar quality and scent. However, studies...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Leptin DNA methylation and maternal and infant pregnancy outcomes in the Rhode Island child health study / by Corina Lesseur Perez.
In utero exposure to maternal malnutrition is associated with increase offspring susceptibility to cardiometabolic and neuropsychiatric disease. Epigenetic mechanisms mediate, at least in part, fetal adaptations to adverse in utero environments...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Sexual selection and sexual conflict in Anolis lizards : from molecules to populations / by M. Catherine Duryea.
Sexual selection is a driver of biodiversity and creates spectacular forms of variation. However, only recently have we begun to understand how this variation operates on the postcopulatory level and how cryptic mechanisms affect male-male...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Habitat selection in the American redstart (Setophaga ruticilla): the importance of early successional habitat and the role of landscape change in population declines.
Wood warblers -- Habitat. Wood warblers -- Effect of habitat modification on. Forest ecology -- New Hampshire. Animal populations -- Mathematical models.
Dartmouth Dissertations

Importance of nest predation to avian population regulation and community structure in a northern hardwoods fores
Bird populations -- New Hampshire; Predation (Biology); Birds -- Nests; Black-throated blue warbler; Chipmunks; Tamiasciurus hudsonicus
Dartmouth Dissertations

Habitat selection by breeding black-throated blue warblers: different patterns at two spatial scales and the use of habitat for foraging and nesting.
Black-throated blue warbler -- Habitat. Black-throated blue warbler -- Behavior. Black-throated blue warbler -- Food. Black-throated blue warbler -- Nests.
Dartmouth Dissertations

The effect of suspended sediments on planktonic rotifers and cladocerans.
Freshwater zooplankton -- Effect of sediments on. Rotifera. Cladocera.
Dartmouth Dissertations

Dendritic cell Fcγ receptor expression and function
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Dartmouth Dissertations

Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

The transcriptional and post-transcriptional regulation of ecdysterone responsive genes.
Genetic regulation. Ecdysterone. Drosophila -- Genetics.
Dartmouth Dissertations

Distribution of sessile rotifers in a bog pond : with particular emphasis on substrate selection by Ptycura Beauchampi larvae
Rotifera. Ptychura Beauchampi.
Dartmouth Dissertations

Causes of tree mortality in wave-regenerated balsam fir forests
Balsam fir. Trees -- Physiology.
Fir waves are spatially and temporally repeating patterns of stand development and destruction in subalpine, balsam fir-dominated forests of the northeastern United States, perpetuated by downwind migration of strips of dying trees, "dieback...
Dartmouth Dissertations

The role of Estradiol in the regulation of the secretory immune system in the female reproductive tract.
Estradiol. Generative organs Female -- Secretions. Generative organs
Dartmouth Dissertations

The flight behavior and dispersal ecology of the red milkweed beetle, Tetraopes tetraopthalmus
Red milkweed beetle. Insects -- Flight. Insects -- Dispersal.
Most detailed studies of insect flight and dispersal have used long flying species as subjects. Little is known of the flight ecology of comparatively short flying species. This thesis reports the findings of a 4 year study of the flight behavior...
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

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