Brain tumors account for ~2% of all cancers, with gliomas accounting for ~70% of all brain tumors. Evidence suggests that extent of resection provides both a quality of life and survival benefit to patients. Recent work has shown the utility of...
Studies have implicated the essential role of Vitamin A (VA) and its active metobolite, retinoic acid (RA) in both host defense and tolerance through manipulation of various immune cells, including T cells, B cells, macrophages and others. CD8⁺ T...
Shape modeling is an important area in computer vision and medical imaging. Shape models have proved valuable in the tasks of object representation, recognition, and classification. This thesis focuses on shape models of 3D surfaces extracted from...
Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...
Near infrared spectroscopy -- Instruments -- Design and construction.;""Magnetic resonance imaging -- Instruments -- Design and construction."";""Breast -- Cancer -- Imaging."";""Breast -- Magnetic resonance imaging."";""Breast -- Cancer --...
Earth's high latitude ionosphere, highly disturbed by particle and energy inputs and associated aurora, is the stage for plasma wave activity across a wide range of frequencies. These waves often exhibit strikingly distinct time-frequency structure...
We describe a set of natural image statistics that are built upon two multi-scale image decompositions, the quadrature mirror filter pyramid decomposition and the local angular harmonic decomposition. These image statistics consist of first- and...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Mutualisms may facilitate coupled population expansion or decline if changes in either partner species lead to similar changes in the other species. However, few studies have measured how both species in a mutualism respond to changes in each...
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
CD antigens. Immune response -- Regulation. Hemoglobin.
CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Snowmelt from seasonal snow covers can be significant in many environments of northern and alpine areas. Water flow and chemical transport resulting from snowmelt have been studied for an understanding of contributions to watersheds or catchments....
Breast -- Cancer -- Tomography. Near infrared spectroscopy. Breast -- Cancer -- Imaging. Breast -- Cancer -- Diagnosis.
Near-infrared (NIR) light provides potential for a new approach to non-invasive detection, diagnosis and clinical management of breast cancer. Using NIR spectroscopic imaging techniques, the physiological information about breast tissue composition...
2-D and 3-D woven composites are becoming materials of choice for the forming of structural parts for an ever-increasing range of industries from infrastructure to aerospace. Research has shown that for a wide range of structural composites, in...
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...